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View Structure Prediction Details

Protein: fax-1
Organism: Caenorhabditis elegans
Length: 419 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for fax-1.

Description E-value Query
Range
Subject
Range
gi|68396885 - gi|68396885|ref|XP_683221.1| PREDICTED: similar to retinoid X receptor-alpha [Danio rerio]
299.0 [0..1] [408..114]

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Predicted Domain #1
Region A:
Residues: [1-92]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDEDEPLNF STSKATEESK EGILGVRSIF NTPLLFPPPM FNAGVISPHI AAALAMSFNQ  60
   61 QRMNASVSPP LDHTTISVNS FPSMGSVKTD SP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [93-185]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTASSPTLCC AVCGDVSSGK HYGILACNGC SGFFKRSVRR RLIYRCQAGT GNCVVDKAHR  60
   61 NQCQACRLKK CLNKGMNKDA VQNERQPRNT ATI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 25.0
Match: 1a6yA
Description: Orphan nuclear receptor reverb
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.00967542385368 bayes_pls_golite062009
DNA binding 3.60745514727532 bayes_pls_golite062009
nucleic acid binding 3.47256374293954 bayes_pls_golite062009
binding 2.96409924710655 bayes_pls_golite062009
transcription activator activity 2.9532663930699 bayes_pls_golite062009
transcription factor activity 2.90769972671972 bayes_pls_golite062009
sequence-specific DNA binding 2.72967350701574 bayes_pls_golite062009
protein binding 2.44501340584871 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.40923942043513 bayes_pls_golite062009
transcription repressor activity 1.88834375049208 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 1.49515149729803 bayes_pls_golite062009
transcription factor binding 1.38523780690867 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.26452462867497 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.68943696300126 bayes_pls_golite062009
transcription cofactor activity 0.58115018700114 bayes_pls_golite062009
catalytic activity 0.101795606736461 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [186-419]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RPALDMDPQN FFREYAGAVS AIMGHSNMMK REDSPSSASD GKTEDEKKDS LQETTMSQLE  60
   61 SVLQWAQQFR LFTVLTNSEK RQIILTQWPR LLCISLCEQA EDVSFDDHLT SLMLKFRRLD 120
  121 VSPAEFNCLK AITIFMKREL SLWRAGWDNR ASIITVYPAG ERGARLVAAA LLLAEHSVMG 180
  181 FGNCVIPLAL VFSTKSRYVI QRHAINSLPA CVPGGTSAHP VLRCSMGSRR EKVI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 43.69897
Match: 1lbdA
Description: LIGAND-BINDING DOMAIN OF THE HUMAN NUCLEAR RECEPTOR RXR-ALPHA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.53061626347066 bayes_pls_golite062009
DNA binding 4.92165988569962 bayes_pls_golite062009
nucleic acid binding 4.78024150262074 bayes_pls_golite062009
transcription activator activity 4.53302455129434 bayes_pls_golite062009
sequence-specific DNA binding 4.11614358606713 bayes_pls_golite062009
transcription factor activity 4.0914094580319 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 3.89763470197726 bayes_pls_golite062009
binding 3.85318710398432 bayes_pls_golite062009
transcription repressor activity 3.83878598697109 bayes_pls_golite062009
protein binding 3.21524787168952 bayes_pls_golite062009
transcription factor binding 2.68044489404568 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.38308182853979 bayes_pls_golite062009
steroid hormone receptor activity 2.30195937604451 bayes_pls_golite062009
receptor activity 2.07573173722434 bayes_pls_golite062009
transcription cofactor activity 1.73827483890179 bayes_pls_golite062009
nuclear hormone receptor binding 1.60419100774741 bayes_pls_golite062009
retinoic acid receptor binding 1.59968001933699 bayes_pls_golite062009
retinoid X receptor binding 1.45560845709347 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.34794228300778 bayes_pls_golite062009
transcription coactivator activity 1.23834725221597 bayes_pls_golite062009
molecular transducer activity 1.19872119297817 bayes_pls_golite062009
signal transducer activity 1.19872119297817 bayes_pls_golite062009
transcription corepressor activity 0.995333369475571 bayes_pls_golite062009
retinoic acid receptor activity 0.853869057774515 bayes_pls_golite062009
protein dimerization activity 0.797229273848179 bayes_pls_golite062009
hormone receptor binding 0.74373733735458 bayes_pls_golite062009
promoter binding 0.58091332905515 bayes_pls_golite062009
protein N-terminus binding 0.57701453824007 bayes_pls_golite062009
thyroid hormone receptor activity 0.49784404390361 bayes_pls_golite062009
protein heterodimerization activity 0.45265806678057 bayes_pls_golite062009
receptor binding 0.418843034756825 bayes_pls_golite062009
ligand-regulated transcription factor activity 0.202197503742221 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.15737167800277 bayes_pls_golite062009
catalytic activity 0.106902059021677 bayes_pls_golite062009

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