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View Structure Prediction Details

Protein: ceh-14
Organism: Caenorhabditis elegans
Length: 351 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ceh-14.

Description E-value Query
Range
Subject
Range
gi|7511466 - gi|7511466|pir||T34266 LIM homeobox protein ceh-14 - Caenorhabditis elegans
185.0 [0..1] [351..1]

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Predicted Domain #1
Region A:
Residues: [1-157]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLGHNILTLG ECDELDNHIV MCSTGLLSPQ EDFSNVNAGH PNNEEAICSL CDKKIRDRFV  60
   61 SKVNGRCYHS SCLRCSTCKD ELGATCFLRE DSMYCRAHFY KKFGTKCSSC NEGIVPDHVV 120
  121 RKASNHVYHV ECFQCFICKR SLETGEEFYL IADDARL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.522879
Match: 2dfyX
Description: No description for 2dfyX was found.

Predicted Domain #2
Region A:
Residues: [158-241]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VCKDDYEQAR DKHCNELEGD GSNKRPRTTI SAKSLETLKQ AYQTSSKPAR HVREQLASET  60
   61 GLDMRVVQVW FQNRRAKEKR LKKD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.221849
Match: 1b8iA
Description: Ultrabithorax (ubx) homeodomain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 2.71840976776163 bayes_pls_golite062009
DNA binding 2.61711182194361 bayes_pls_golite062009
binding 2.59102816487173 bayes_pls_golite062009
transcription factor activity 2.18905180070231 bayes_pls_golite062009
nucleic acid binding 1.93681952439958 bayes_pls_golite062009
sequence-specific DNA binding 1.69885241317809 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.35613772918036 bayes_pls_golite062009
transcription activator activity 0.9706572970185 bayes_pls_golite062009
protein binding 0.853351196918381 bayes_pls_golite062009
transcription repressor activity 0.67392957114349 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.44172618015361 bayes_pls_golite062009
transcription factor binding 0.22865859991459 bayes_pls_golite062009
chromatin binding 0.203837749053719 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [242-351]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AGRRWKSSNR AESDSNSPIE SINGQSPNYL YLDHPMDDGN ESNYLFHSRE QTPDKYYRNE  60
   61 TPSTDPPPMH MTTPSVLTTN FSTPLSLSTN VYNLPPPESQ LIPHMTPQYI 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle