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View Structure Prediction Details

Protein: mys-2
Organism: Caenorhabditis elegans
Length: 550 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for mys-2.

Description E-value Query
Range		 Subject
Range
MYST3 - MYST histone acetyltransferase (monocytic leukemia) 3
 494.0 [0..5] [550..311]

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Predicted Domain #1
Region A:
Residues: [1-171] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKREPRKRA HDSTNEAAAP GGNDSEPPQQ QIMPIINKRY MVEKFIINTV KKVVAVIIHI  60
   61 DFRKPPQEVR TNNYKSIENH EQGAKELMYY VHYEELDRRN DEWITLDKIL VNEVVVEPVI 120
  121 KVPTKAPVED LHKEIVVGPP VIKPSGALTR SQRRTLEEYS HLKTDLNDLD A

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.39794
Match: 1wgsA
Description: Solution Structure of the Tudor Domain from Mouse Hypothetical Protein Homologous to Histone Acetyltransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription repressor activity 4.08500855631983 bayes_pls_golite062009
chromatin binding 3.84065302930105 bayes_pls_golite062009
transcription regulator activity 3.64390820819794 bayes_pls_golite062009
methylated histone residue binding 3.42338304360938 bayes_pls_golite062009
binding 3.06758476214113 bayes_pls_golite062009
protein binding 2.66728689880621 bayes_pls_golite062009
transcription elongation regulator activity 2.46353586381231 bayes_pls_golite062009
nucleic acid binding 2.19167058827256 bayes_pls_golite062009
DNA binding 2.05514577638135 bayes_pls_golite062009
histone binding 2.00388175060339 bayes_pls_golite062009
transcription activator activity 1.46529895769882 bayes_pls_golite062009
sequence-specific DNA binding 1.10020047862576 bayes_pls_golite062009
DNA-dependent ATPase activity 0.998957812785999 bayes_pls_golite062009
general transcriptional repressor activity 0.75184432495983 bayes_pls_golite062009
DNA helicase activity 0.726970683178132 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.494788451379878 bayes_pls_golite062009
transcription corepressor activity 0.294457188332415 bayes_pls_golite062009
catalytic activity 0.14067200158938 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [172-550] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TTARLEREHE ERTKVKNIPQ ITIGAHEILA WYYSPFPPDC ENLDIYMCEY CLLYTPHHER  60
   61 FKQHIDTCKV RQPPGNEIYR KDHLSVYEVD GSGQKLFQPF FAPFPPKLPI FQLYCQCLCL 120
  121 LSKLFMDHKT LYFDVDDFMF YVLCETDEHG AHIVGYFSRE VESANNLACI MVFPPFQKKG 180
  181 YGKLLIQFSY ELSRREGYIG MPEKPLSDLG KVSYRSYWWW RLMKLFHIHQ GHTVTATFLS 240
  241 NESGIAVDDI VSTLITMRMC RQYKEPEFIP GEWYVRIHRK IVDHCVMCGY GKPPRLLLDR 300
  301 TKVRWAPAQT RPEFERQQQR TAAAMTSRRA SKSQNVTPLV TPLATPPIEQ KPEDTYTPSP 360
  361 LTDHHVATDA PDHISLPLN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 106.0
Match: 2givA
Description: No description for 2givA was found.

Predicted functions:

Term Confidence Notes
N-acetyltransferase activity 10.330867741687 bayes_pls_golite062009
histone acetyltransferase activity 10.2385402730839 bayes_pls_golite062009
lysine N-acetyltransferase activity 10.2385402730839 bayes_pls_golite062009
N-acyltransferase activity 10.2097972775096 bayes_pls_golite062009
acetyltransferase activity 9.5414870492393 bayes_pls_golite062009
acyltransferase activity 8.84144467104026 bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups 8.80032457938662 bayes_pls_golite062009
transferase activity, transferring acyl groups 8.58458341779614 bayes_pls_golite062009
7.30820970670781 bayes_pls_golite062009
5.22897636875434 bayes_pls_golite062009
H3 histone acetyltransferase activity 3.57980162499154 bayes_pls_golite062009
transferase activity 2.87429355361226 bayes_pls_golite062009
transcription regulator activity 2.24760844790231 bayes_pls_golite062009
transcription activator activity 2.22111981353244 bayes_pls_golite062009
nucleic acid binding 2.13750665291344 bayes_pls_golite062009
catalytic activity 1.97933499002461 bayes_pls_golite062009
transcription repressor activity 1.31507488567214 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.294475171667 bayes_pls_golite062009
binding 1.22537494136129 bayes_pls_golite062009
transcription coactivator activity 1.2180007740195 bayes_pls_golite062009
transcription factor binding 1.13174003342838 bayes_pls_golite062009
protein binding 1.12627968510377 bayes_pls_golite062009
glycylpeptide N-tetradecanoyltransferase activity 0.774009286200155 bayes_pls_golite062009
myristoyltransferase activity 0.774009286200155 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.605899196605446 bayes_pls_golite062009
histone binding 0.582104626133107 bayes_pls_golite062009
transcription cofactor activity 0.31196049232138 bayes_pls_golite062009
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