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View Structure Prediction Details

Protein: hsf-1
Organism: Caenorhabditis elegans
Length: 671 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for hsf-1.

Description E-value Query
Range
Subject
Range
gi|45643032 - gi|45643032|gb|AAS72410.1| heat shock transcription factor 1 [Caenorhabditis elegans]
336.0 [0..1] [671..1]

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Predicted Domain #1
Region A:
Residues: [1-72]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQPTGNQIQQ NQQQQQQLIM RVPKQEVSVS GAARRYVQQA PPNRPPRQNH QNGAIGGKKS  60
   61 SVTIQEVPNN AY

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [73-273]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LETLNKSGNN KVDDDKLPVF LIKLWNIVED PNLQSIVHWD DSGASFHISD PYLFGRNVLP  60
   61 HFFKHNNMNS MVRQLNMYGF RKMTPLSQGG LTRTESDQDH LEFSHPCFVQ GRPELLSQIK 120
  121 RKQSARTVED KQVNEQTQQN LEVVMAEMRA MREKAKNMED KMNKLTKENR DMWTQMGSMR 180
  181 QQHARQQQYF KKLLHFLVSV M

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 43.69897
Match: 1hksA
Description: SOLUTION STRUCTURE OF THE DNA-BINDING DOMAIN OF DROSOPHILA HEAT SHOCK TRANSCRIPTION FACTOR
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.77201910025409 bayes_pls_golite062009
binding 3.52874320222492 bayes_pls_golite062009
DNA binding 3.44642410378325 bayes_pls_golite062009
nucleic acid binding 3.25777282180864 bayes_pls_golite062009
transcription factor activity 2.83460075788873 bayes_pls_golite062009
transcription repressor activity 2.39237599101586 bayes_pls_golite062009
sequence-specific DNA binding 2.08341148210578 bayes_pls_golite062009
transcription activator activity 1.98504395280033 bayes_pls_golite062009
protein binding 0.753698599635855 bayes_pls_golite062009
transcription factor binding 0.63938506997853 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.49916895549368 bayes_pls_golite062009
specific transcriptional repressor activity 0.0565989703351002 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [274-339]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QPGLSKRVAK RGVLEIDFCA ANGTAGPNSK RARMNSEEGP YKDVCDLLES LQRETQEPFS  60
   61 RRFTNN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [340-517]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EGPLISEVTD EFGNSPVGRG SAQDLFGDTF GAQSSRYSDG GATSSREQSP HPIISQPQSN  60
   61 SAGAHGANEQ KPDDMYMGSG PLTHENIHRG ISALKRDYQG ASPASGGPST SSSAPSGAGA 120
  121 GARMAQKRAA PYKNATRQMA QPQQDYSGGF VNNYSGFMPS DPSMIPYQPS HQYLQPHQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [518-671]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KLMAIEDQHH PTTSTSSTNA DPHQNLYSPT LGLSPSFDRQ LSQELQEYFT GTDTSLESFR  60
   61 DLVSNHNWDD FGNNVPLDDD EEGSEDPLRQ LALENAPETS NYDGAEDLLF DNEQQYPENG 120
  121 FDVPDPNYLP LADEEIFPHS PALRTPSPSD PNLV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle