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View Structure Prediction Details

Protein: ahr-1
Organism: Caenorhabditis elegans
Length: 602 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ahr-1.

Description E-value Query
Range
Subject
Range
gi|4580533, gi|1... - gi|4580533|gb|AAD24413.1|AF057308_1 hypoxia-inducible factor-1 alpha [Rattus norvegicus], gi|1324224...
346.0 [0..7] [554..7]

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Predicted Domain #1
Region A:
Residues: [1-109]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYASKRRQRN FKRVRDPPKQ LTNTNPSKRH RERLNGELET VAMLLPYDSS TISRLDKLSV  60
   61 LRLAVSFLQC KAHFQACLHN SQFLSAGFPM STHSYSYQPH PPIPFSNKV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.39794
Match: 1am9A
Description: SREBP-1a
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 3.17840258752324 bayes_pls_golite062009
DNA binding 2.56280954568684 bayes_pls_golite062009
transcription regulator activity 2.54719844409677 bayes_pls_golite062009
nucleic acid binding 2.42823673922558 bayes_pls_golite062009
transcription factor activity 2.29471798726915 bayes_pls_golite062009
protein binding 1.59929864805879 bayes_pls_golite062009
transcription factor binding 0.78456571881611 bayes_pls_golite062009
transcription activator activity 0.537618291807254 bayes_pls_golite062009
sequence-specific DNA binding 0.39197881175959 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.3402368922433 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [110-515]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTIFDLRIGT PMLDPEESNF EEISLKSLGG FILVLNDNGE IYYASENVEN YLGFHQSDVL  60
   61 HQPVYDLIHS EDRDDIRQQL DSNFHIPTSS ASNQFDVFAP QNSKYLERNV NARFRCLLDN 120
  121 TCGFLRIDMR GKLMSLHGLP SSYVMGRTAS GPVLGMICVC TPFVPPSTSD LASEDMILKT 180
  181 KHQLDGALVS MDQKVYEMLE IDETDLPMPL YNLVHVEDAV CMAEAHKEAI KNGSSGLLVY 240
  241 RLVSTKTRRT YFVQSSCRMF YKNSKPESIG LTHRLLNEVE GTMLLEKRST LKAKLLSFDD 300
  301 SFLQSPRNLQ STAALPLPSV LKDDQDCLEP STSNSLFPSV PVPTPTTTKA NRRRKENSHE 360
  361 IVPTIPSIPI PTHFDMQMFD PSWNHGVHPP AWPHDVYHLT QYPPTY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 50.69897
Match: 1wa9A
Description: Crystal Structure of the PAS repeat region of the Drosophila clock protein PERIOD
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [516-602]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PHPPGTVGYP DVQIAPVDYP GWHPNDIHMT QLPHGFTPDA QKLVPPHPQM SHFTEYPTPS  60
   61 THHDLHHHPL KQDNFHLISE VTNLLGT

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle