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View Structure Prediction Details

Protein: tba-4
Organism: Caenorhabditis elegans
Length: 448 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for tba-4.

Description E-value Query
Range
Subject
Range
gi|115960583, gi... - gi|72057626|ref|XP_780117.1| PREDICTED: similar to tubulin, alpha 2 isoform 1 [Strongylocentrotus pu...
617.0 [0..1] [448..1]

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Predicted Domain #1
Region A:
Residues: [1-448]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MREVISIHVG QAGVQIGNAC WELYCLEHGI QPDGTMPSEQ QNEGGSFTTF FSDTGNGRYV  60
   61 PRSIFVDLEP TVVDEIRTGN YKKLFHPEQM ITGKEDAANN YARGHYTVGK ELIDTTLDRI 120
  121 RRLADNCSGL QGFFVFHSFG GGTGSGFTSL LMERLSVDYG KKSKLEFSIY PAPQVSTAVV 180
  181 EPYNSILTTH TTLEHSDCAF MVDNEAIYDI CKRNLDVDRP SYTNLNRIIS QVVSSITASL 240
  241 RFDGALNVDL NEFQTNLVPY PRIHFPLASY TPLISAEKAY HEALSVNDIT NSCFEPANQM 300
  301 VKCDPRNGKY MAVCLLYRGD VVPKDVNTAI TAIKTKRSVQ FVDWCPTGFK VGINYQPPTV 360
  361 VPGGDLAKVP RAVCMLSNTT AIAEAWSRLD YKFDLMYAKR AFVHWYVGEG MEEGEFTEAR 420
  421 EDLAALEKDY EEVGADSNEG LEEDGEEY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 176.0
Match: 1z2bA
Description: Tubulin-colchicine-vinblastine: stathmin-like domain complex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
structural constituent of cytoskeleton 4.04224160177678 bayes_pls_golite062009
structural molecule activity 3.32779015200848 bayes_pls_golite062009
tubulin binding 2.4432045213385 bayes_pls_golite062009
cytoskeletal protein binding 2.24606230377981 bayes_pls_golite062009
binding 2.00508289492248 bayes_pls_golite062009
GTPase activity 1.87512665946067 bayes_pls_golite062009
nucleoside-triphosphatase activity 1.77500173070686 bayes_pls_golite062009
pyrophosphatase activity 1.7017047947554 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 1.68267378160702 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1.68038087466376 bayes_pls_golite062009
protein binding 1.60795853516357 bayes_pls_golite062009
MHC class I protein binding 1.46574865275013 bayes_pls_golite062009
gamma-tubulin binding 1.02742779831447 bayes_pls_golite062009
hydrolase activity 0.502038132260603 bayes_pls_golite062009
receptor binding 0.00945891657658993 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle