YRC Public Data Repository - Protein Structure Prediction

Protein:	ced-10
Organism:	Caenorhabditis elegans
Length:	129 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ced-10.

Description	E-value	Query Range	Subject Range
CRE16067, FL81_1... - RP15185 WBGene00061078 locus:Cre-rab-1 status:Confirmed, null gi\|157761211 - gi\|157761211\|ref\|XP_001672948.1\| Hypothetical protein CBG01077 [Caenorhabditis briggsae AF16] gi\|39588485, gi\|... - gi\|39588485\|emb\|CAE58008.1\| Hypothetical protein CBG01077 [Caenorhabditis briggsae], gi\|187038224\|em...	157.0	[0..4]	[128..12]
rab-1 - RAS-related protein status:Confirmed UniProt:Q9UAQ6 protein_id:AAC69218.1	157.0	[0..4]	[128..12]
gi\|50738954 - gi\|50738954\|ref\|XP_419342.1\| PREDICTED: similar to ras-related protein [Gallus gallus]	157.0	[0..4]	[128..200]
gi\|157108598, gi... - gi\|157108598\|ref\|XP_001650303.1\| ras-related protein Rab-1A, putative [Aedes aegypti], gi\|108879268\|...	156.0	[0..4]	[128..14]
gi\|54637791, gi\|... - gi\|54637791\|gb\|EAL27193.1\| GA17362 [Drosophila pseudoobscura pseudoobscura], gi\|125773595\|ref\|XP_001... gi\|195166166, gi... - gi\|195166166\|ref\|XP_002023906.1\| GL27164 [Drosophila persimilis], gi\|194106066\|gb\|EDW28109.1\| GL2716... gi\|125773595\|ref... - GA17362-PA [Drosophila pseudoobscura], GA17362 [Drosophila pseudoobscura pseudoobscura]	154.0	[0..4]	[128..12]
YPT1_PHYIN - Ras-like GTP-binding protein YPT1 OS=Phytophthora infestans GN=YPT1 PE=3 SV=1	154.0	[0..4]	[128..9]
gi\|47211161 - gi\|47211161\|emb\|CAF92536.1\| unnamed protein product [Tetraodon nigroviridis]	153.0	[0..4]	[128..9]
gi\|53733986 - gb\|AAH83951.1\| Unknown (protein for MGC:97957) [Xenopus laevis] gi\|55741705 - ref\|NP_001003153.1\| RAB1A, member RAS oncogene family [Canis familiaris] gi\|120419448, gi... - gi\|76629653\|ref\|XP_869337.1\| PREDICTED: similar to RAB1, member RAS oncogene family isoform 2 [Bos t... gi\|109103156 - gi\|109103156\|ref\|XP_001090072.1\| PREDICTED: similar to RAB1, member RAS oncogene family isoform 4 [M... gi\|61355917, gi\|... - gi\|61355926\|gb\|AAX41191.1\| RAB1A member RAS oncogene family [synthetic construct], gi\|61355917\|gb\|AA... tr\|G1TCS8\|G1TCS8... - pep:novel chromosome:oryCun2:2:121177308:121212010:1 gene:ENSOCUG00000017003 transcript:ENSOCUT00000... RAB1A - RAB1A, member RAS oncogene family RAB1A_RAT - Ras-related protein Rab-1A OS=Rattus norvegicus GN=Rab1A PE=1 SV=3 RAB1A_CANLF - Ras-related protein Rab-1A OS=Canis lupus familiaris GN=RAB1A PE=1 SV=3 gi\|159906367 - gi\|159906367\|gb\|ABX10872.1\| RAB1A [Capra hircus] RAB1A_MOUSE - Ras-related protein Rab-1A OS=Mus musculus GN=Rab1A PE=1 SV=3 tr\|M3VYP9\|M3VYP9... - RAB1A, member RAS oncogene family OS=Felis catus GN=RAB1A PE=4 SV=1 gi\|149727528 - gi\|149727528\|ref\|XP_001493347.1\| PREDICTED: similar to RAB1A, member RAS oncogene family [Equus caba...	153.0	[0..4]	[128..12]
gi\|61365844, gi\|... - gi\|61365844\|gb\|AAX42772.1\| RAB1A member RAS oncogene family [synthetic construct], gi\|54695924\|gb\|AA...	153.0	[0..4]	[128..12]
gi\|2144601, gi\|2... - pir\|\|TVRTYP GTP-binding protein Rab1 - rat, gi\|206553\|gb\|AAA42006.1\| ras protein	153.0	[0..4]	[128..12]

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Predicted Domain #1

Region A:
Residues: [1-129]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDGRP INLGLWDTAG  60
   61 QEDYDRLRER RLQPVSQTQG YVMAKEIKAV KYLECSALTQ RGLKQVFDEA IRAVLTPPQR 120
  121 AKKSKCTVL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	34.522879
Match:	1i4dD
Description:	Rac
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
nucleoside-triphosphatase activity	2.02893949194171	bayes_pls_golite062009
binding	2.00548409930693	bayes_pls_golite062009
pyrophosphatase activity	1.97909493766908	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	1.95844964816653	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	1.95658009428828	bayes_pls_golite062009
transporter activity	1.442880936187	bayes_pls_golite062009
ATPase activity	1.42257610975945	bayes_pls_golite062009
nucleic acid binding	1.34113621222575	bayes_pls_golite062009
transmembrane transporter activity	1.28442352896828	bayes_pls_golite062009
DNA binding	1.16175440171961	bayes_pls_golite062009
transcription regulator activity	1.05321763338965	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
hydrolase activity	0.98565595572967	bayes_pls_golite062009
ATPase activity, coupled	0.732723553251109	bayes_pls_golite062009
purine nucleotide binding	0.725611289205392	bayes_pls_golite062009
nucleotide binding	0.717697610309727	bayes_pls_golite062009
purine ribonucleotide binding	0.713814218071151	bayes_pls_golite062009
ribonucleotide binding	0.713752628021599	bayes_pls_golite062009
guanyl nucleotide binding	0.388587892299301	bayes_pls_golite062009
guanyl ribonucleotide binding	0.372638007722845	bayes_pls_golite062009
GTP binding	0.364508542344128	bayes_pls_golite062009
GTPase activity	0.234351968078991	bayes_pls_golite062009
ATP binding	0.19169045543599	bayes_pls_golite062009
protein binding	0.170837278876362	bayes_pls_golite062009
adenyl ribonucleotide binding	0.165732470448462	bayes_pls_golite062009
adenyl nucleotide binding	0.162060759063149	bayes_pls_golite062009
substrate-specific transporter activity	0.144154288308693	bayes_pls_golite062009
active transmembrane transporter activity	0.114463153989353	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: