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View Structure Prediction Details

Protein: pde-1
Organism: Caenorhabditis elegans
Length: 664 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for pde-1.

Description E-value Query
Range
Subject
Range
PDE4D_RAT - cAMP-specific 3',5'-cyclic phosphodiesterase 4D OS=Rattus norvegicus GN=Pde4d PE=1 SV=4
635.0 [0..14] [664..133]

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Predicted Domain #1
Region A:
Residues: [1-138]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNRARKTSSC GCFRSAFCLL KPSTSSASEE HGDSDKKLLS VQLITPRDEE EQTSSRSIKI  60
   61 PPLDLNGLDC KKNAVAARRA GRRRTSEGGG VRGKGHFAEV VLDGLQRPVS LLRNQKEKSN 120
  121 SDDNCQEKEP TSPSSSRK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [139-252]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KSYDNAPALE SLEKLRYILH QLNSGQLPLE DLKRNIEYAA LVLETAYMDE TRRICDEDDD  60
   61 LAEVTPETVP DEVREWLAAT FTRQNAGKKR DKPKFKSVAN AIRTGIFFEK LFRK

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 29.886057
Match: PF08499.3
Description: No description for PF08499.3 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [253-664]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQVVQCPIPP EIAELMKEVC TWSFSPFQLN EVSEGHALKY VGFELFNRYG FMDRFKVPLT  60
   61 ALENYLSALE VGYSKHNNPY HNVVHAADVT QSSHFMLSQT GLANSLGDLE LLAVLFGALI 120
  121 HDYEHTGHTN NFHIQSQSQF AMLYNDRSVL ENHHVSSCFR LMKEDDKNIL THLTRDEYKE 180
  181 LRNMVIEIVL ATDMSTHFMQ IKTMKSMLSL PEGIDKNKAL CLIVHACDIS HPAKPWNLHE 240
  241 RWTEGVLEEF FRQGDLEASM GLPYSPLCDR HTVHVADSQI GFIDFIVEPT MVVCGELLVK 300
  301 MVEPLVSLPP TDSLFPPSVD GGDDKSPSNA LSPLPDLRNS STSPSSIRRI PLNYAGKLDI 360
  361 PTPWMKFLHE NKAHWKERAA KEEEERKIKE AAEAEAAAKQ VEENKENGVT TN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 106.0
Match: 1tazA
Description: Catalytic Domain Of Human Phosphodiesterase 1B
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
3',5'-cyclic-GMP phosphodiesterase activity 4.00066983687916 bayes_pls_golite062009
3',5'-cyclic-nucleotide phosphodiesterase activity 3.67241800633934 bayes_pls_golite062009
cyclic-nucleotide phosphodiesterase activity 3.66153187976312 bayes_pls_golite062009
phosphoric diester hydrolase activity 3.35655066482707 bayes_pls_golite062009
3',5'-cyclic-AMP phosphodiesterase activity 2.18711955312275 bayes_pls_golite062009
hydrolase activity 1.17086565360856 bayes_pls_golite062009
catalytic activity 1.07048165010262 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.98531713516841 bayes_pls_golite062009
binding 0.585341229695032 bayes_pls_golite062009
phosphoric ester hydrolase activity 0.511207383357891 bayes_pls_golite062009
protein binding 0.062487758537192 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle