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View Structure Prediction Details

Protein: unc-4
Organism: Caenorhabditis elegans
Length: 252 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for unc-4.

Description E-value Query
Range
Subject
Range
gi|2696969 - gi|2696969|dbj|BAA24022.1| PAX6 LS [Cynops pyrrhogaster]
140.0 [0..9] [246..162]
gi|5758937 - gi|5758937|gb|AAD50902.1|AF169413_1 paired-box transcription factor +- isoform [Ambystoma mexicanum]
137.0 [0..9] [246..143]
gi|8132379 - gi|8132379|gb|AAF73269.1|AF154553_1 paired domain transcription factor variant B [Xenopus laevis]
135.0 [0..9] [246..131]
gi|786328 - gi|786328|gb|AAB32671.1| Pax-6 [Rattus sp.]
gi|480038, gi|446399 - gi|480038|pir||S36166 paired box transcription factor Pax-6 - rat (fragment), gi|446399|prf||1911405...
135.0 [0..9] [181..38]
gi|46228363 - gi|46228363|gb|EAK89262.1| putative DNA-directed RNA polymerase,possible RNA polymerase A/beta'/A'' ...
gi|66359288 - gi|66359288|ref|XP_626822.1| DNA-directed RNA polymerase,possible RNA polymerase A/beta'/A'' subunit...
132.0 [0..3] [251..1556]

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Predicted Domain #1
Region A:
Residues: [1-152]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIGALHACVD AEPKIINDIW ADFWKSQINS VLLNPSDGSE TYLASDNGKS TSSREQSTSP  60
   61 DDDNLLMNED DGIALEDDND TGESAAKRRR TRTNFSGWQL EELESAFEAS HYPDVFMREA 120
  121 LAMRLDLLES RVQVWFQNRR AKWRKREQNR NG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 25.69897
Match: 1fjlA
Description: Paired protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.41271657675151 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.26183812259792 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
transcription activator activity 1.77700860354597 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.14886080629275 bayes_pls_golite062009
chromatin binding 1.04132983826241 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [153-252]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSEIKKDDGE QMETKALPTF PFSIDSILAV SRVPRGRRPN AKYPRVQACK NLSPFMIPLF  60
   61 PITQPGGNVI REKSPPLPTQ QSQIVATNAL TTVAELLKSV 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle