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View Structure Prediction Details

Protein: exc-7
Organism: Caenorhabditis elegans
Length: 456 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for exc-7.

Description E-value Query
Range
Subject
Range
gi|76633735 - gi|76633735|ref|XP_881462.1| PREDICTED: similar to poly(A) binding protein, cytoplasmic 1 isoform 6 ...
254.0 [0..33] [455..2]

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Predicted Domain #1
Region A:
Residues: [1-207]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTMEALLTPN NNNVPTSPVQ TTYTSTQRYC SAPNVDIGES KTNLIINYLP QGMTQEEVRS  60
   61 LFTSIGEIES CKLVRDKVTG QSLGYGFVNY VREEDALRAV SSFNGLRLQN KTIKVSYARP 120
  121 SNDQIKGSNL YVSGIPKSMT LHELESIFRP FGQIITSRIL SDNVTGLSKG VGFVRFDKKD 180
  181 EADVAIKTLN GSIPSGCSEQ ITVKFAN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 42.39794
Match: 1fxlA
Description: Hu antigen D (Hud)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 5.15097136329571 bayes_pls_golite062009
nucleic acid binding 4.92126426323641 bayes_pls_golite062009
mRNA binding 4.05281507540116 bayes_pls_golite062009
binding 3.64400841800969 bayes_pls_golite062009
2.83802439076672 bayes_pls_golite062009
transcription regulator activity 1.92450390013691 bayes_pls_golite062009
DNA binding 1.8021593476478 bayes_pls_golite062009
poly-pyrimidine tract binding 1.69629099229571 bayes_pls_golite062009
single-stranded RNA binding 1.46469774223879 bayes_pls_golite062009
transcription factor activity 1.15127506309683 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
transcription repressor activity 1.06887262556449 bayes_pls_golite062009
mRNA 3'-UTR binding 0.824614388276642 bayes_pls_golite062009
mRNA 5'-UTR binding 0.625848256054783 bayes_pls_golite062009
translation repressor activity, nucleic acid binding 0.461000905454505 bayes_pls_golite062009
structure-specific DNA binding 0.43716526938634 bayes_pls_golite062009
sequence-specific DNA binding 0.383589644462932 bayes_pls_golite062009
snRNA binding 0.249682711188639 bayes_pls_golite062009
single-stranded DNA binding 0.2202184446161 bayes_pls_golite062009
structural molecule activity 0.166336846372115 bayes_pls_golite062009
translation regulator activity 0.117211881967154 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [208-365]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPASNNPKGL LSDLEAVQQA ATTLVPLSTI LGAPTLRATA GGIGPMHHAP ITSKYRYSPM  60
   61 GAITAVSQPT ATLPADYLTT SALLQMSQLN ALAGLNPFAT ATAVPDFTAS LIAHQQQQHA 120
  121 VAQQHAAQTA SPPATNGQVA GLAAHAQLSA LSASVAAT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [366-456]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPPSDTAGYC LFVYNLSSDT DDTLLWQLFS QFGAIVNVKI LRDLTQQCKG YAFVSMSNYT  60
   61 EAYNAMLSLN GTNLAGKTLQ VVFKSSTPYR A

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 23.522879
Match: 2d9pA
Description: No description for 2d9pA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle