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View Structure Prediction Details

Protein: cpar-1
Organism: Caenorhabditis elegans
Length: 261 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cpar-1.

Description E-value Query
Range
Subject
Range
hcp-3 - Histone H3 similarity status:Confirmed UniProt:P34470 protein_id:CAA80160.1
284.0 [0..1] [261..1]
gi|88943485 - gi|88943485|ref|XP_497711.2| PREDICTED: similar to H3 histone, family 2 isoform 2 [Homo sapiens]
235.0 [0..123] [260..45]
gi|50728592 - gi|50728592|ref|XP_416193.1| PREDICTED: similar to histone protein Hist2h3c1 [Gallus gallus]
232.0 [0..120] [260..618]
gi|76612880 - gi|76612880|ref|XP_871849.1| PREDICTED: similar to H3 histone, family 2 isoform 2 [Bos taurus]
231.0 [0..122] [260..206]
gi|109508757, gi... - gi|109508757|ref|XP_001075226.1| PREDICTED: similar to H3 histone, family 3B [Rattus norvegicus], gi...
228.0 [0..122] [260..16]
gi|77548740, gi|... - gi|77548740|gb|ABA91537.1| histone H3 [Oryza sativa (japonica cultivar-group)], gi|62701879|gb|AAX92...
227.0 [0..123] [260..1]
gi|74004208 - gi|74004208|ref|XP_545397.2| PREDICTED: similar to histone 1, H2ai (predicted) [Canis familiaris]
227.0 [0..122] [260..16]

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Predicted Domain #1
Region A:
Residues: [1-96]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADDGPIIEE IAEKNGRVAR IMQRLQHDTQ RVTSVPGFNT SATGYADLIA LLDQYKNDLE  60
   61 AVGFNDLEQA RRRAPSVDIT VGSNSTNLVD YSHGRH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [97-261]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DMPSHRRHDS SDEEITAANS HHQSPINVGN RNDTDGTNGR NGSRAGSSSS DRVRMIAGRN  60
   61 RISKTRRYRP GQKALEEIRK YQESEDLLIP KAPFARLVRE IMQTSTPFSS DLRIRSDAIN 120
  121 ALQEASEALL VQMFDGSSLI SAHSKRATLT TTDVQLYRRL CLPNL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 56.39794
Match: 1u35A
Description: Crystal structure of the nucleosome core particle containing the histone domain of macroH2A
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 2.55554809461094 bayes_pls_golite062009
binding 1.73700145395396 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.69908144382455 bayes_pls_golite062009
DNA binding 1.04127970884713 bayes_pls_golite062009
nucleic acid binding 0.86554830065808 bayes_pls_golite062009
transcription regulator activity 0.57702121108343 bayes_pls_golite062009
protein binding 0.260428734715028 bayes_pls_golite062009
transcription initiation factor activity 0.107780301417639 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle