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View Structure Prediction Details

Protein: cpar-1
Organism: Caenorhabditis elegans
Length: 261 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cpar-1.

Description E-value Query
Range
Subject
Range
hcp-3 - Histone H3 similarity status:Confirmed UniProt:P34470 protein_id:CAA80160.1
284.0 [0..1] [261..1]
gi|88943485 - gi|88943485|ref|XP_497711.2| PREDICTED: similar to H3 histone, family 2 isoform 2 [Homo sapiens]
235.0 [0..123] [260..45]
gi|50728592 - gi|50728592|ref|XP_416193.1| PREDICTED: similar to histone protein Hist2h3c1 [Gallus gallus]
232.0 [0..120] [260..618]
gi|76612880 - gi|76612880|ref|XP_871849.1| PREDICTED: similar to H3 histone, family 2 isoform 2 [Bos taurus]
231.0 [0..122] [260..206]
gi|109508757, gi... - gi|109508757|ref|XP_001075226.1| PREDICTED: similar to H3 histone, family 3B [Rattus norvegicus], gi...
228.0 [0..122] [260..16]
gi|77548740, gi|... - gi|77548740|gb|ABA91537.1| histone H3 [Oryza sativa (japonica cultivar-group)], gi|62701879|gb|AAX92...
227.0 [0..123] [260..1]
gi|74004208 - gi|74004208|ref|XP_545397.2| PREDICTED: similar to histone 1, H2ai (predicted) [Canis familiaris]
227.0 [0..122] [260..16]

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Predicted Domain #1
Region A:
Residues: [1-96]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADDGPIIEE IAEKNGRVAR IMQRLQHDTQ RVTSVPGFNT SATGYADLIA LLDQYKNDLE  60
   61 AVGFNDLEQA RRRAPSVDIT VGSNSTNLVD YSHGRH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.637 a.74.1 Cyclin-like
View Download 0.611 a.74.1 Cyclin-like
View Download 0.538 a.74.1 Cyclin-like
View Download 0.421 a.74.1 Cyclin-like
View Download 0.405 a.74.1 Cyclin-like

Predicted Domain #2
Region A:
Residues: [97-261]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DMPSHRRHDS SDEEITAANS HHQSPINVGN RNDTDGTNGR NGSRAGSSSS DRVRMIAGRN  60
   61 RISKTRRYRP GQKALEEIRK YQESEDLLIP KAPFARLVRE IMQTSTPFSS DLRIRSDAIN 120
  121 ALQEASEALL VQMFDGSSLI SAHSKRATLT TTDVQLYRRL CLPNL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 56.39794
Match: 1u35A
Description: Crystal structure of the nucleosome core particle containing the histone domain of macroH2A
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 2.55554809461094 bayes_pls_golite062009
binding 1.73700145395396 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.69908144382455 bayes_pls_golite062009
DNA binding 1.04127970884713 bayes_pls_golite062009
nucleic acid binding 0.86554830065808 bayes_pls_golite062009
transcription regulator activity 0.57702121108343 bayes_pls_golite062009
protein binding 0.260428734715028 bayes_pls_golite062009
transcription initiation factor activity 0.107780301417639 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle