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View Structure Prediction Details

Protein: SPBC1105.07c
Organism: Schizosaccharomyces pombe
Length: 442 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPBC1105.07c.

Description E-value Query
Range
Subject
Range
PCID2 - PCI domain containing 2
gi|55640145 - gi|55640145|ref|XP_509757.1| PREDICTED: hypothetical protein isoform 5 [Pan troglodytes]
335.0 [0..1] [417..4]
gi|7022473 - gi|7022473|dbj|BAA91611.1| unnamed protein product [Homo sapiens]
333.0 [0..1] [417..4]
gi|6753486, gi|4... - ref|NP_034069.1| COP9 (constitutive photomorphogenic) homolog, subunit 2 [Mus musculus], gi|4588637...
331.0 [0..14] [411..27]
CSN2_XENLA - COP9 signalosome complex subunit 2 (Fragment) OS=Xenopus laevis GN=csn2 PE=2 SV=1
330.0 [0..14] [411..28]
CSN2_DANRE - COP9 signalosome complex subunit 2 OS=Danio rerio GN=cops2 PE=2 SV=1
330.0 [0..14] [411..30]
gi|62751437, gi|... - gi|62751437|ref|NP_001015820.1| COP9 constitutive photomorphogenic homolog subunit 2 [Xenopus (Silur...
330.0 [0..14] [411..30]

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Predicted Domain #1
Region A:
Residues: [1-172]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLNDFLQTL SNAVGEKNSN TLEKCIILDP SEPSFQQLSK TLFLDRKGKN KLNGTIQKEF  60
   61 GRIRGWKELV TTYFEYVENA ASSPDQRKWE LLQNLYSNLT TCFSHIDGAW LCTIVKRVSK 120
  121 LYVKLSLQLD TSTPTLEDSF DGNGFIQRKY VSDASRNVLR TFNSILSDRQ QN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [173-316]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 INPSKKDAIF CIANLLCLLY FRLKQIRLCQ TIQANVISSG ADISRATMAE LVTFRYYLGR  60
   61 CHLYQRKIHQ AKDHLLFSFL QCPDECYHQK RLSLIYLTTC LLILGKSPTK GLLEKYKLTA 120
  121 AFEPLIKALK SGDIKSFRLS LEDN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [317-442]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SRRKWFIKRG IYLTLLDRCE IILWRNLFRK VFLFTFEQSQ KTPHVSGSYL LTAARLSTND  60
   61 NSYDMDDVEC ICVSLIDQGY IKGYIIHASS TLVLKKDPSF GFSVIESLMP IARNDHAEKE 120
  121 FFHANA

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.78
Match: 1ufmA
Description: Solution structure of the PCI domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.23858959608048 bayes_pls_golite062009
DNA binding 4.54024488199476 bayes_pls_golite062009
nucleic acid binding 4.30331577005505 bayes_pls_golite062009
binding 3.89976494610525 bayes_pls_golite062009
transcription factor activity 3.82269332595313 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.41045867230388 bayes_pls_golite062009
transcription activator activity 2.13702350917359 bayes_pls_golite062009
sequence-specific DNA binding 2.12567455635303 bayes_pls_golite062009
transcription repressor activity 1.9708626903609 bayes_pls_golite062009
structure-specific DNA binding 1.28654223481433 bayes_pls_golite062009
transcription elongation regulator activity 1.19572229887868 bayes_pls_golite062009
RNA binding 0.999156053511857 bayes_pls_golite062009
transcription factor binding 0.752335897765285 bayes_pls_golite062009
protein binding 0.749376520208656 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.490809930581315 bayes_pls_golite062009
double-stranded DNA binding 0.300710367763552 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.171423850692861 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle