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View Structure Prediction Details

Protein: snd1
Organism: Schizosaccharomyces pombe
Length: 878 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for snd1.

Description E-value Query
Range
Subject
Range
gi|109068090 - gi|109068090|ref|XP_001088001.1| PREDICTED: staphylococcal nuclease domain containing 1 [Macaca mula...
724.0 [0..6] [877..280]
gi|114615787 - gi|114615787|ref|XP_527879.2| PREDICTED: staphylococcal nuclease domain containing 1 [Pan troglodyte...
714.0 [0..6] [877..98]
gi|197097522 - gi|197097522|ref|NP_001125262.1| staphylococcal nuclease and tudor domain containing 1 [Pongo abelii...
gi|55727490 - gi|55727490|emb|CAH90500.1| hypothetical protein [Pongo abelii]
712.0 [0..6] [877..21]
gi|73975868 - gi|73975868|ref|XP_532436.2| PREDICTED: similar to Staphylococcal nuclease domain containing protein...
711.0 [0..6] [877..99]
gi|62088600 - gi|62088600|dbj|BAD92747.1| EBNA-2 co-activator variant [Homo sapiens]
711.0 [0..6] [877..75]
SND1_BOVIN - Staphylococcal nuclease domain-containing protein 1 OS=Bos taurus GN=SND1 PE=1 SV=1
710.0 [0..6] [877..21]
SND1_MOUSE - Staphylococcal nuclease domain-containing protein 1 OS=Mus musculus GN=Snd1 PE=1 SV=1
708.0 [0..6] [877..21]

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Predicted Domain #1
Region A:
Residues: [1-165]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQYVSSMIK YAQSGDSFNI LIKDNAKKIT EKQFSLAYVE CPRFRREGDE PFAFEAQEFS  60
   61 RRLVVGRPAS VSTLYVIPTS KREYGRIRTS EFDLAESLLR EGLAKLRPEA TRNEGTSENS 120
  121 YFVSLEEAQD HAQQYKLGIW GPSDDVVVTE KANPANPAKF LKAHK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 27.522879
Match: 2f0uA
Description: No description for 2f0uA was found.

Predicted Domain #2
Region A:
Residues: [166-313]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKKLNGIVET IRNGDQVRVR LFLSPKQHQL VTISLAGVRC PRSTFTATSP EQTSSEQEPC  60
   61 GDEAKQFVVT RLLQRNVVIE LLDLAPNGVS FLGNVLHPAG NIATFLLSSG LGRVADNHIS 120
  121 ALGPETMQSL RTIERKAKIS RLGIWKNI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.69897
Match: 1rknA
Description: Solution structure of 1-110 fragment of Staphylococcal Nuclease with G88W mutation
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
catalytic activity 0.545407789079971 bayes_pls_golite062009
nuclease activity 0.47992885240838 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [314-476]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVSIPDINSL SLKDYSAVVS RVISTDTLEV RKDNGVECRI QLSSIRHPRP SNEKEAPYQL  60
   61 EAREFLRKKI IGKRVQVSLD FIRPGQNDLP AINNCTVKLS DGTNVALMVV KSGYATVIRY 120
  121 RMDSVDRSPI YDFLIEAEKA AQEGRKGMWS GKKPAYENIV NAS

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 15.853872
Match: PF00565.8
Description: No description for PF00565.8 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [477-627]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ESSLRSRQYL SSLQRTRKLS VIIENVISGS RFRCFCPKEN CYFMFACAGI RTPRTARNDQ  60
   61 EKGEPFAEES LSLAKSLLQH DAQVEILSVD NNGCFLGDIY VNHDTNFALK LLSQGLAWCQ 120
  121 GYASQSNVQY SQYHDTEAAA KEQKVGMWHD Y

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.63
Match: 1staA
Description: ACCOMMODATION OF INSERTION MUTATIONS ON THE SURFACE AND IN THE INTERIOR OF STAPHYLOCOCCAL NUCLEASE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
catalytic activity 0.532570324528821 bayes_pls_golite062009
nuclease activity 0.220383451830433 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [628-878]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPPEKKAAST EKESENTVKE PIYLDIVLSD IAEDGKFSFQ IIGTGIQQLE TLMSDLGSLK  60
   61 KSFKPSEKIN VGMNVAAISA LDNAMYRGRV LRCDRENQAA DVLLYDYGSV EQIPFKNISS 120
  121 LPDTYTKLKP QAQLARLSYV QLPPPSSDYY EDARLVFREL AMNKGLVAKV DGHEGNVYSV 180
  181 TLYNPSDGSD FSDCINAQLV ALGMASVIPK KKTSHFEKDT ASLNILEEHQ QEARLNHIGF 240
  241 WVYGDPLEYE D

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 54.522879
Match: 2hqeA
Description: No description for 2hqeA was found.

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.34067645460735 bayes_pls_golite062009
transcription repressor activity 3.06808416304746 bayes_pls_golite062009
binding 3.03932294945523 bayes_pls_golite062009
nucleic acid binding 2.39870293911569 bayes_pls_golite062009
DNA binding 2.38812251097879 bayes_pls_golite062009
histone methyltransferase activity 2.07175269912162 bayes_pls_golite062009
histone binding 1.90499817035542 bayes_pls_golite062009
protein binding 1.76914488602752 bayes_pls_golite062009
transcription corepressor activity 1.55732936245077 bayes_pls_golite062009
chromatin binding 1.53982562888655 bayes_pls_golite062009
transcription factor binding 1.49481919243505 bayes_pls_golite062009
transcription factor activity 1.41108699101741 bayes_pls_golite062009
DNA-methyltransferase activity 1.40512830025766 bayes_pls_golite062009
transcription cofactor activity 1.36802409360413 bayes_pls_golite062009
DNA (cytosine-5-)-methyltransferase activity 1.34644198396495 bayes_pls_golite062009
lysine N-methyltransferase activity 0.72077437792468 bayes_pls_golite062009
histone-lysine N-methyltransferase activity 0.72077437792468 bayes_pls_golite062009
protein-lysine N-methyltransferase activity 0.72077437792468 bayes_pls_golite062009
retinoid X receptor binding 0.47657909093375 bayes_pls_golite062009
retinoic acid receptor binding 0.43555270589681 bayes_pls_golite062009
transcription activator activity 0.262486595331603 bayes_pls_golite062009
sequence-specific DNA binding 0.141502107934206 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle