YRC Public Data Repository - Protein Structure Prediction

Protein:	erg27
Organism:	Schizosaccharomyces pombe
Length:	338 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for erg27.

Description	E-value	Query Range	Subject Range
FABG_THEMA - 3-oxoacyl-[acyl-carrier-protein] reductase FabG OS=Thermotoga maritima GN=fabG PE=3 SV=1 FABG_THEMA - 3-oxoacyl-[acyl-carrier-protein] reductase FabG OS=Thermotoga maritima (strain ATCC 43589 / MSB8 / D...	231.0	[0..3]	[300..4]
gi\|255313843 - gi\|255313843\|ref\|ZP_05355426.1\| 3-oxoacyl-[acyl-carrier protein] reductase [Clostridium difficile QC... gi\|255516524 - gi\|255516524\|ref\|ZP_05384200.1\| 3-oxoacyl-[acyl-carrier protein] reductase [Clostridium difficile QC... gi\|255649624 - gi\|255649624\|ref\|ZP_05396526.1\| 3-oxoacyl-[acyl-carrier protein] reductase [Clostridium difficile QC... gi\|254974717 - gi\|254974717\|ref\|ZP_05271189.1\| 3-oxoacyl-[acyl-carrier protein] reductase [Clostridium difficile QC... gi\|255092105 - gi\|255092105\|ref\|ZP_05321583.1\| 3-oxoacyl-[acyl-carrier protein] reductase [Clostridium difficile CI... gi\|90575404, gi\|... - gi\|90575404\|ref\|ZP_01231888.1\| hypothetical protein CdifQ_02001165 [Clostridium difficile QCD-32g58]...	229.0	[0..3]	[302..5]
gi\|115250215, gi... - gi\|126698778\|ref\|YP_001087675.1\| 3-oxoacyl-[acyl-carrier protein] reductase [Clostridium difficile 6... gi\|255306086 - gi\|255306086\|ref\|ZP_05350258.1\| 3-oxoacyl-[acyl-carrier protein] reductase [Clostridium difficile AT... gi\|255100197 - gi\|255100197\|ref\|ZP_05329174.1\| 3-oxoacyl-[acyl-carrier protein] reductase [Clostridium difficile QC...	228.0	[0..3]	[302..5]
gi\|146296617, gi... - gi\|82501013\|ref\|ZP_00886394.1\| 3-oxoacyl-(acyl-carrier-protein) reductase [Caldicellulosiruptor sacc...	228.0	[0..5]	[302..7]
gi\|33639742, gi\|... - gi\|33861010\|ref\|NP_892571.1\| 3-oxoacyl-[acyl-carrier protein] reductase [Prochlorococcus marinus sub...	227.0	[0..1]	[301..1]
gi\|91070409 - gi\|91070409\|gb\|ABE11321.1\| 3-oxoacyl-acyl-carrier protein [uncultured Prochlorococcus marinus clone ...	224.0	[0..1]	[301..1]
gi\|72003471, gi\|... - gi\|72383621\|ref\|YP_292976.1\| 3-oxoacyl-[acyl-carrier-protein] reductase [Prochlorococcus marinus str...	224.0	[0..3]	[302..8]
gi\|78712337, gi\|... - gi\|78778838\|ref\|YP_396950.1\| 3-oxoacyl-[acyl-carrier-protein] reductase [Prochlorococcus marinus str...	223.0	[0..1]	[301..1]
gi\|110803752, gi... - gi\|110803752\|ref\|YP_698460.1\| 3-ketoacyl-(acyl-carrier-protein) reductase [Clostridium perfringens S...	223.0	[0..1]	[302..1]
gi\|28210515, gi\|... - gi\|28210515\|ref\|NP_781459.1\| 3-ketoacyl-(acyl-carrier-protein) reductase [Clostridium tetani E88], g...	222.0	[0..3]	[300..7]

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Predicted Domain #1

Region A:
Residues: [1-338]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFRKYALIT GSNSGLGFGI ATRLLQFYQP RLQDEPEVFT VILTCRSREK AEDACRRLKE  60
   61 FFPDRKIRLE YVLLDLSNMA SVEAAVQDIA TRFPKLDFVY LNAGAWDLEG IQWLKAIFST 120
  121 LINPIQALTH PTFYKETAGR VSNDSLGYIF ESNVFGHFYL KNRLAELKVL RSSTKVVLTS 180
  181 SLVAEKKSLD FEDLQCFHGE QPYQSSKRLL DVLHYAELEK GLPFEQYLVH PGLCTTNMYE 240
  241 TFLGPILVMC AKLGFYICRL LGSPWHTISP YVAAFAFLWT ALHATKEDQS IKWGAAVTRF 300
  301 GHERVLSTPV ELILPSEQEK ALEYMTKLYQ EWKKKLVS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	47.69897
Match:	1yxmA
Description:	Crystal structure of peroxisomal trans 2-enoyl CoA reductase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
steroid dehydrogenase activity	3.70115036051018	bayes_pls_golite062009
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	3.56748749904419	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	2.27417613545298	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.97774592602866	bayes_pls_golite062009
catalytic activity	1.79741889688267	bayes_pls_golite062009
C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity	1.03845584151228	bayes_pls_golite062009
3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity	0.744959961067911	bayes_pls_golite062009
signal transducer activity	0.620476349006324	bayes_pls_golite062009
molecular transducer activity	0.620476349006324	bayes_pls_golite062009
binding	0.553666136934364	bayes_pls_golite062009
retinol dehydrogenase activity	0.48259320361048	bayes_pls_golite062009
oxidoreductase activity	0.39101464838432	bayes_pls_golite062009
receptor activity	0.0485610523889735	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: