YRC Public Data Repository - Protein Structure Prediction

Protein:	pli1
Organism:	Schizosaccharomyces pombe
Length:	727 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for pli1.

Description	E-value	Query Range	Subject Range
gi\|114673021 - gi\|114673021\|ref\|XP_001147006.1\| PREDICTED: protein inhibitor of activated STAT X isoform 2 [Pan tro...	379.0	[0..17]	[456..1]
gi\|83405047 - gi\|83405047\|gb\|AAI11061.1\| PIAS2 protein [Homo sapiens]	377.0	[0..14]	[456..7]
gi\|73961203 - gi\|73961203\|ref\|XP_866387.1\| PREDICTED: similar to protein inhibitor of activated STAT X isoform alp...	373.0	[0..17]	[531..1]
gi\|76651999 - gi\|76651999\|ref\|XP_883125.1\| PREDICTED: similar to protein inhibitor of activated STAT X isoform alp...	372.0	[0..17]	[531..1]
gi\|109015278 - gi\|109015278\|ref\|XP_001095153.1\| PREDICTED: protein inhibitor of activated STAT, 3 [Macaca mulatta]	368.0	[0..12]	[589..77]
gi\|74150351 - gi\|74150351\|dbj\|BAE32224.1\| unnamed protein product [Mus musculus]	368.0	[0..14]	[501..7]
gi\|16758050, gi\|... - gi\|4176737\|gb\|AAD13349.1\| androgen receptor interacting protein; ARIP [Rattus norvegicus], gi\|167580...	367.0	[0..14]	[531..7]

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Predicted Domain #1

Region A:
Residues: [1-74]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNQANFLQEL PNVLKRLETG LIIPQLKDIL RVFGLRLSGT KAELITRIKQ LIERIAIENN  60
   61 TTSWEALKKA IDGD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	16.39794
Match:	1v66A
Description:	Solution structure of human p53 binding domain of PIAS-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
SUMO ligase activity	7.09211721404578	bayes_pls_golite062009
small conjugating protein ligase activity	5.19208367271658	bayes_pls_golite062009
acid-amino acid ligase activity	4.23914967265256	bayes_pls_golite062009
transcription regulator activity	3.15902332919799	bayes_pls_golite062009
DNA binding	2.92139817158415	bayes_pls_golite062009
binding	2.85946414867169	bayes_pls_golite062009
nucleic acid binding	2.76384947675043	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	2.74673402515898	bayes_pls_golite062009
transcription factor binding	1.8538346588987	bayes_pls_golite062009
transcription cofactor activity	1.68730216999933	bayes_pls_golite062009
protein binding	1.4634286530239	bayes_pls_golite062009
transcription activator activity	1.25644547219412	bayes_pls_golite062009
nuclear hormone receptor binding	1.20451045950565	bayes_pls_golite062009
RNA polymerase II transcription factor activity	1.16985510361731	bayes_pls_golite062009
steroid hormone receptor binding	1.14520328838371	bayes_pls_golite062009
transcription repressor activity	1.08109201779928	bayes_pls_golite062009
androgen receptor binding	0.98494234316847	bayes_pls_golite062009
transcription corepressor activity	0.84593119507905	bayes_pls_golite062009
transcription coactivator activity	0.84537546395033	bayes_pls_golite062009
hormone receptor binding	0.81375575057479	bayes_pls_golite062009
catalytic activity	0.454272578060498	bayes_pls_golite062009
structure-specific DNA binding	0.258128144495696	bayes_pls_golite062009
ligase activity	0.165914056383691	bayes_pls_golite062009
double-stranded DNA binding	0.00901028599610032	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [75-261]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VTSAVCILKY NTYQIYSAAA PIAPPSSASG NRSYSRPFAP VVHSRIRFRK SPFYDILEQF  60
   61 NAPFVVPACV GTRNTISFSF HVTPPALSKL LNDPKQYRVY LFSTPSETIG FGNCLMEFPT 120
  121 PQMELRINNQ VAHANYRRLK GKPGTTNPAD ITDLVSKYAG PPGNNVVIYY MNSTKSYSVV 180
  181 VCFVKVY

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [262-403]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TIENLVDQIK SRKAESKEKI IERIKNDNQD ADIIATSTDI SLKCPLSFSR ISLPVRSVFC  60
   61 KHIQCFDASA FLEMNKQTPS WMCPVCASHI QFSDLIIDGF MQHILESTPS NSETITVDPE 120
  121 GNWKLNTFDE PVESSEDEFV PK

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.86
Match:	2cklB
Description:	No description for 2cklB was found.

Predicted Domain #4

Region A:
Residues: [404-727]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKVIELSDGE GISTMANKSN DQPTRRASTH NSGPPAKRKR ESLVIDLTIS DDDENVATST  60
   61 TESPSNATKE NSLSRNVQSP NIDTAISNRS TNVRHGHPGF KDYTVENSPA SRERSTSESA 120
  121 QSSVHMGYAG EGGLLSGALR APSQQNNNNS NTQHSINLHT IVPSPYEPPL SVTPSTAITN 180
  181 LSIPESNRTN SSASSKSFTM NDLILPPLHL KNTTQTNNAH EDAQSSNLSQ NHSLFYERIP 240
  241 QRPSYRIEKQ NKGIYEDENE QSISAMPIPR AHPQLPKNLL SQTAGPLWDE QQDAQVDWNS 300
  301 ELQSNNSYHN SGFEGTGNTF QSID

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.31
Match:	1h1kI
Description:	THE BLUETONGUE VIRUS (BTV) CORE BINDS DSRNA
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: