YRC Public Data Repository - Protein Structure Prediction

Protein:	SPCC16C4.06c
Organism:	Schizosaccharomyces pombe
Length:	413 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPCC16C4.06c.

Description	E-value	Query Range	Subject Range
PUS1_ASHGO - tRNA pseudouridine synthase 1 OS=Ashbya gossypii GN=PUS1 PE=3 SV=1 PUS1_ASHGO - tRNA pseudouridine synthase 1 OS=Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL ...	352.0	[0..31]	[387..61]
PUS1_YEAST - tRNA pseudouridine synthase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PUS1 PE=1 ... gi\|151942589 - gi\|151942589\|gb\|EDN60935.1\| tRNA-pseudouridine synthase [Saccharomyces cerevisiae YJM789] PUS1 - tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA... gi\|190407751 - gi\|190407751\|gb\|EDV11016.1\| tRNA pseudouridine synthase [Saccharomyces cerevisiae RM11-1a]	345.0	[0..33]	[413..71]
PUS1_CANGA - tRNA pseudouridine synthase 1 OS=Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622... PUS1_CANGA - tRNA pseudouridine synthase 1 OS=Candida glabrata GN=PUS1 PE=3 SV=1	339.0	[0..33]	[400..83]
gi\|71022667, gi\|... - gi\|71022667\|ref\|XP_761563.1\| hypothetical protein UM05416.1 [Ustilago maydis 521], ref\|XP_403031.1\| ...	326.0	[0..28]	[400..112]
PUS1_KLULA - tRNA pseudouridine synthase 1 OS=Kluyveromyces lactis GN=PUS1 PE=3 SV=1 PUS1_KLULA - tRNA pseudouridine synthase 1 OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBR...	322.0	[0..31]	[387..93]
PUS1_YARLI - tRNA pseudouridine synthase 1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=PUS1 PE=3 SV=1 PUS1_YARLI - tRNA pseudouridine synthase 1 OS=Yarrowia lipolytica GN=PUS1 PE=3 SV=1	319.0	[0..21]	[401..69]
PUS1 - pseudouridylate synthase 1 gi\|123999259, gi... - gi\|123999259\|gb\|ABM87208.1\| pseudouridylate synthase 1 [synthetic construct], gi\|123989720\|gb\|ABM838...	306.0	[0..21]	[383..40]
gi\|114647862 - gi\|114647862\|ref\|XP_001139560.1\| PREDICTED: hypothetical protein [Pan troglodytes]	306.0	[0..21]	[383..68]

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Predicted Domain #1

Region A:
Residues: [1-342]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHSLLRPSRF SANQSVLCLL QRHRVFFSSI SVKPRKRMVY CVVSYRGTGF AGLQYNANVK  60
   61 TIQDTLFQAF ARVGAVVQVN ADSPKKIRMC SAARTDKGVH AIVNVLGLKV LDNQPLPHVV 120
  121 NLVNDILPPC IRVWKMARTF NSFSPHTVCD SRVYEYWLPV SSLLTPRPCT LEAYVIAKAS 180
  181 EKAFPINETL SHLANLSKQD CVANSLSEPF RLSKPKLDFL KHACTMFRGT HRFHSYTTEK 240
  241 GFSDASSRRF LLDVRVDNLH IDKLNRQWVK LIFHGQSFMK HQIRKMVGIL IHLTRTGWNA 300
  301 QVLLNTFNNS YRIRIPRAPA EFLLLNQPIF QAFNKKCSRF DH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	80.30103
Match:	2nqpA
Description:	No description for 2nqpA was found.

Predicted functions:

Term	Confidence	Notes
pseudouridine synthase activity	5.19957135839682	bayes_pls_golite062009
intramolecular transferase activity	3.78688422405974	bayes_pls_golite062009
isomerase activity	2.91720316078381	bayes_pls_golite062009
transcription regulator activity	2.31595692797262	bayes_pls_golite062009
catalytic activity	2.02180970970004	bayes_pls_golite062009
binding	1.84674955201903	bayes_pls_golite062009
DNA binding	1.71136719569439	bayes_pls_golite062009
nucleic acid binding	1.59449441921256	bayes_pls_golite062009
RNA binding	0.706879359688019	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [343-413]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EPVEWSCAQK GIDQFAHSFL RTPMFDCFIS SESFQSFFIL QKQFQLFQDL ALLTSFDFLE  60
   61 PSSRRDILGE K

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.341	0.403	pseudouridylate synthase activity	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.396	0.070	pseudouridylate synthase activity	a.77.1	DEATH domain
View	Download	0.318	0.064	pseudouridylate synthase activity	d.211.1	Ankyrin repeat
View	Download	0.540	0.006	pseudouridylate synthase activity	a.24.7	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View	Download	0.296	0.003	pseudouridylate synthase activity	a.118.11	Cytochrome c oxidase subunit E

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: