YRC Public Data Repository - Protein Structure Prediction

Protein:	mst1
Organism:	Schizosaccharomyces pombe
Length:	463 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for mst1.

Description	E-value	Query Range	Subject Range
ESA1_ASHGO - Histone acetyltransferase ESA1 OS=Ashbya gossypii GN=ESA1 PE=3 SV=1 ESA1_ASHGO - Histone acetyltransferase ESA1 OS=Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL...	569.0	[0..1]	[463..86]
ESA1_YEAST - Histone acetyltransferase ESA1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ESA1 PE=1... gi\|190407549 - gi\|190407549\|gb\|EDV10816.1\| NuA4 complex component [Saccharomyces cerevisiae RM11-1a] gi\|151945330 - gi\|151945330\|gb\|EDN63573.1\| NuA4 histone acetyltransferase subunit [Saccharomyces cerevisiae YJM789] ESA1 - Catalytic subunit of the histone acetyltransferase complex (NuA4) that acetylates four conserved int...	567.0	[0..1]	[463..1]
ESA1_GIBZE - Histone acetyltransferase ESA1 OS=Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31... ESA1_GIBZE - Histone acetyltransferase ESA1 OS=Gibberella zeae GN=ESA1 PE=3 SV=1	566.0	[0..8]	[463..15]
ESA1_NEUCR - Histone acetyltransferase esa-1 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / ... ESA1_NEUCR - Histone acetyltransferase esa-1 OS=Neurospora crassa GN=esa-1 PE=3 SV=1	562.0	[0..8]	[463..13]
gi\|76658150 - gi\|76658150\|ref\|XP_887601.1\| PREDICTED: similar to HIV-1 Tat interactive protein, 60kDa isoform 1 is...	559.0	[0..20]	[457..39]
gi\|73983070 - gi\|73983070\|ref\|XP_866353.1\| PREDICTED: similar to HIV-1 Tat interactive protein, 60kDa isoform 1 is...	559.0	[0..20]	[457..39]
gi\|40742885, gi\|... - gi\|67901016\|ref\|XP_680764.1\| hypothetical protein AN7495.2 [Aspergillus nidulans FGSC A4], ref\|XP_41...	559.0	[0..2]	[463..829]
gi\|61371562 - gi\|61371562\|gb\|AAX43690.1\| HIV-1 Tat interacting protein [synthetic construct]	555.0	[0..16]	[457..2]
gi\|208966484, gi... - gi\|60654987\|gb\|AAX32057.1\| HIV-1 Tat interacting protein [synthetic construct], gi\|208966484\|dbj\|BAG... KAT5_PONAB - Histone acetyltransferase KAT5 OS=Pongo abelii GN=KAT5 PE=2 SV=1 TIP60_PONPY - Histone acetyltransferase HTATIP - Pongo pygmaeus (Orangutan) gi\|36287060, gi\|... - gi\|62531188\|gb\|AAH93032.1\| K(lysine) acetyltransferase 5 [Homo sapiens], gi\|36287060\|ref\|NP_874368.1... gi\|114638604 - gi\|114638604\|ref\|XP_001170139.1\| PREDICTED: HIV-1 Tat interactive protein, 60kDa isoform 2 [Pan trog...	555.0	[0..16]	[457..2]

Back

Predicted Domain #1

Region A:
Residues: [1-171]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNDVDDESK IETKSYEAKD IVYKSKVFAF KDGEYRKAEI LMIQKRTRGV VYYVHYNDYN  60
   61 KRLDEWITID NIDLSKGIEY PPPEKPKKAH GKGKSSKRPK AVDRRRSITA PSKTEPSTPS 120
  121 TEKPEPSTPS GESDHGSNAG NESLPLLEED HKPESLSKEQ EVERLRFSGS M

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	16.69897
Match:	1wgsA
Description:	Solution Structure of the Tudor Domain from Mouse Hypothetical Protein Homologous to Histone Acetyltransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription repressor activity	4.08500855631983	bayes_pls_golite062009
chromatin binding	3.84065302930105	bayes_pls_golite062009
transcription regulator activity	3.64390820819794	bayes_pls_golite062009
methylated histone residue binding	3.42338304360938	bayes_pls_golite062009
binding	3.06758476214113	bayes_pls_golite062009
transcription elongation regulator activity	2.46353586381231	bayes_pls_golite062009
nucleic acid binding	2.19167058827256	bayes_pls_golite062009
DNA binding	2.05514577638135	bayes_pls_golite062009
histone binding	2.00388175060339	bayes_pls_golite062009
protein binding	1.61683263008775	bayes_pls_golite062009
DNA-dependent ATPase activity	0.998957812785999	bayes_pls_golite062009
general transcriptional repressor activity	0.75184432495983	bayes_pls_golite062009
DNA helicase activity	0.726970683178132	bayes_pls_golite062009
ATP-dependent DNA helicase activity	0.494788451379878	bayes_pls_golite062009
transcription corepressor activity	0.294457188332415	bayes_pls_golite062009
catalytic activity	0.14067200158938	bayes_pls_golite062009
transcription activator activity	0.136090220479238	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [172-463]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VQNPHEIARI RNINKICIGD HEIEPWYFSP YPKEFSEVDI VYICSFCFCY YGSERQFQRH  60
   61 REKCTLQHPP GNEIYRDDYI SFFEIDGRKQ RTWCRNICLL SKLFLDHKML YYDVDPFLFY 120
  121 CMCRRDEYGC HLVGYFSKEK ESSENYNLAC ILTLPQYQRH GYGKLLIQFS YELTKREHKH 180
  181 GSPEKPLSDL GLISYRAYWA EQIINLVLGM RTETTIDELA NKTSMTTNDV LHTLQALNML 240
  241 KYYKGQFIIC ISDGIEQQYE RLKNKKRRRI NGDLLADWQP PVFHPSQLRF GW

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	126.0
Match:	1fy7A
Description:	Histone acetyltransferase ESA1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
N-acetyltransferase activity	10.330867741687	bayes_pls_golite062009
histone acetyltransferase activity	10.2385402730839	bayes_pls_golite062009
lysine N-acetyltransferase activity	10.2385402730839	bayes_pls_golite062009
N-acyltransferase activity	10.2097972775096	bayes_pls_golite062009
acetyltransferase activity	9.5414870492393	bayes_pls_golite062009
acyltransferase activity	8.84144467104026	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	8.80032457938662	bayes_pls_golite062009
transferase activity, transferring acyl groups	8.58458341779614	bayes_pls_golite062009
	7.30820970670781	bayes_pls_golite062009
	5.22897636875434	bayes_pls_golite062009
H3 histone acetyltransferase activity	3.57980162499154	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	2.87587084880956	bayes_pls_golite062009
transferase activity	2.87429355361226	bayes_pls_golite062009
transcription regulator activity	2.24760844790231	bayes_pls_golite062009
nucleic acid binding	2.13750665291344	bayes_pls_golite062009
catalytic activity	1.97933499002461	bayes_pls_golite062009
transcription repressor activity	1.31507488567214	bayes_pls_golite062009
binding	1.22537494136129	bayes_pls_golite062009
transcription coactivator activity	1.2180007740195	bayes_pls_golite062009
transcription factor binding	1.13174003342838	bayes_pls_golite062009
transcription activator activity	0.891911076312861	bayes_pls_golite062009
glycylpeptide N-tetradecanoyltransferase activity	0.774009286200155	bayes_pls_golite062009
myristoyltransferase activity	0.774009286200155	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.605899196605446	bayes_pls_golite062009
histone binding	0.582104626133107	bayes_pls_golite062009
transcription cofactor activity	0.31196049232138	bayes_pls_golite062009
protein binding	0.075825416385311	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: