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View Structure Prediction Details

Protein: SPAC11E3.05
Organism: Schizosaccharomyces pombe
Length: 1323 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPAC11E3.05.

Description E-value Query
Range
Subject
Range
WDR59 - WD repeat domain 59
689.0 [0..307] [1318..3]
gi|41946841, gi|... - gi|41946841|gb|AAH66082.1| Wdr59 protein [Mus musculus], gi|148679552|gb|EDL11499.1| WD repeat domai...
684.0 [0..307] [1318..3]
gi|109508794 - gi|109508794|ref|XP_001075913.1| PREDICTED: similar to WD repeat domain 59 [Rattus norvegicus]
683.0 [0..339] [1318..31]
gi|76639864 - gi|76639864|ref|XP_605015.2| PREDICTED: similar to WD repeat domain 59 [Bos taurus]
681.0 [0..327] [1318..128]
gi|114663658 - gi|114663658|ref|XP_511107.2| PREDICTED: WD repeat domain 59 isoform 3 [Pan troglodytes]
681.0 [0..307] [1318..3]
gi|109129206 - gi|109129206|ref|XP_001109464.1| PREDICTED: similar to WD repeat domain 59 isoform 3 [Macaca mulatta...
679.0 [0..307] [1318..3]
gi|73957391 - gi|73957391|ref|XP_536785.2| PREDICTED: similar to WD repeat domain 59 [Canis familiaris]
664.0 [0..307] [1318..3]

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Predicted Domain #1
Region A:
Residues: [1-107]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRELQGDDSS RKSPPSDSVV KNSSPIDYEH SLKSLQDERT LNYPNKQFNS ENPSSYYNMD  60
   61 DSGELCNFEL EKDSLESMIH ESSTALSAQS NTAQDGDQLA SSSTISK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.522879
Match: 2ojhA
Description: No description for 2ojhA was found.

Predicted Domain #2
Region A:
Residues: [108-485]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DHSETLDNKL NDSKILIKKA SNSFANFSES VRSSTIVAYS QTPTQRLQGL TSISSSSFDD  60
   61 GSYGSRRISF NSQGVSGRLR RNMDSTVIIP SEDEDLQLPS NSNSNVEYGP FDSTTFDRQL 120
  121 SIEVNQPVGA MSLSPCGRDI ALASRYGLLV LDLDNPYNPP RMLRHSTPWE VADTQWNVHA 180
  181 ARDQWVVSTS SQKTIVWNLA LPNDRAIEFM LHGHTRAVTD MNWHRQNPDV LATCSIDSSV 240
  241 HCWDLRSPRF PVNSFYDWHN GATQVKWNYK NPHILASSHG RLVRIWDDRY GSAPLHTIKT 300
  301 SENITKINGL EFNRACETRL LTCAMDRTVK FWNYEKSTEE PEHLITTDSP VWKARFTPFG 360
  361 DGVILMPQRG DNSVHMYD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 57.69897
Match: 2ovpB
Description: No description for 2ovpB was found.

Predicted Domain #3
Region A:
Residues: [486-636]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CRNLDKEGPR AVHRFAGHTD QVKEFLWRCR GEDVFDRDLR DFQLITWSKD HHVRLWPIGN  60
   61 DILNSMGHDR TKPVPFKLTR LGAKYRTYSR EPLKQSLINT ECDSSDAMNS FDSNFGAERA 120
  121 NTSDLSRGFV AFANRKKSKY NLPGSSGFMT R

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 64.0
Match: 1vyhC
Description: PAF-AH Holoenzyme: Lis1/Alfa2
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [637-868]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STKSTNPMTP LNWLRGISMG RLGNADWEVP QNLGEELSWI GQKYSNVSFE KIDVAERTCT  60
   61 ISLNAPILPD DGYAYIRLHV YFPNNYPISA TPVFQLERSS AFNDEQFNYV FNTLTSISDQ 120
  121 CISSHKYCMD ACLSYLSGNL SVDEIWKLGF QKDNSDSSSE SSADIFQDVF PSMPDFRGGD 180
  181 RGLSHKHQNI PLPKTCAAIF CGNDELVCFF TIKADESAAQ ATANRETHGR QK

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.19
Match: 2daxA
Description: No description for 2daxA was found.

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 5.92248163880907 bayes_pls_golite062009
small conjugating protein ligase activity 5.9086319430991 bayes_pls_golite062009
acid-amino acid ligase activity 5.0261946125134 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 3.408033340951 bayes_pls_golite062009
ligase activity 1.54502300784947 bayes_pls_golite062009
catalytic activity 0.843965854182766 bayes_pls_golite062009
protein binding 0.838850681576122 bayes_pls_golite062009
binding 0.756713779508906 bayes_pls_golite062009
NEDD8 ligase activity 0.259607886535948 bayes_pls_golite062009
protein serine/threonine kinase activity 0.158224176330677 bayes_pls_golite062009
protein kinase activity 0.156381916938112 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.140898268391068 bayes_pls_golite062009
SUMO ligase activity 0.114161137460685 bayes_pls_golite062009
kinase activity 0.0626237835448453 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [869-948]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LFESFGVLDS SNSVADSDST NYDDENSLNR GGTSESDSEF IWDVDESNSG SIVFPKSKTS  60
   61 INLNNINSAS ASIMGSRFGA 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [949-1172]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ADIFMSKRPS TKGSNRPSIL LSKPSHDFHV VRIISMSKYL PVKRALAAEY VVDTGDKVTV  60
   61 CNKNAEVSAK HNYYRLAKVW LMLGRLLGHL SRTENKDHIN DEEAFPWLKS PLAKWVVNSL 120
  121 LDYYASQCNT QMLAMLACVL DIPNPKKQSG NTSADQVLFN QPKQVTEKLG VQLNLPKTKI 180
  181 LEKVSSHSLA QITALREKEP KDADSTYSKE KIFSATSTVH LQLM

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [1173-1323]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DYDKQNNDFV DAQEIAYTKL LQQKFIQWRA TYAEQLDLWG FFIPKLEMLK FNAHEFSSPS  60
   61 EKTLVNHCNS CNSTTSNTRI CEKCYSLVPR MSCTFCCLSI HGLCIVCGLC LHVMHEDCYK 120
  121 EWFSNGDSIS QSCSSGCGCK CQFQHMSLEK V

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.84
Match: 2ep4A
Description: No description for 2ep4A was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle