YRC Public Data Repository - Protein Structure Prediction

Protein:	SPCC18B5.08c
Organism:	Schizosaccharomyces pombe
Length:	973 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPCC18B5.08c.

Description	E-value	Query Range	Subject Range
SYI_MOOTA - Isoleucine--tRNA ligase OS=Moorella thermoacetica (strain ATCC 39073) GN=ileS PE=3 SV=1	822.0	[0..32]	[971..1]
gi\|22296058, gi\|... - gi\|22299873\|ref\|NP_683120.1\| isoleucyl-tRNA synthetase [Thermosynechococcus elongatus BP-1], gi\|2229...	795.0	[0..24]	[968..26]
SYI_GEOKA - Isoleucine--tRNA ligase OS=Geobacillus kaustophilus (strain HTA426) GN=ileS PE=3 SV=1 SYI_GEOKA - Isoleucyl-tRNA synthetase OS=Geobacillus kaustophilus GN=ileS PE=3 SV=1	795.0	[0..32]	[970..1]
SYI_THEEB - Isoleucine--tRNA ligase OS=Thermosynechococcus elongatus (strain BP-1) GN=ileS PE=3 SV=2 SYI_SYNEL - Isoleucyl-tRNA synthetase OS=Synechococcus elongatus GN=ileS PE=3 SV=2	791.0	[0..28]	[968..2]
gi\|86606359 - gi\|86606359\|ref\|YP_475122.1\| isoleucyl-tRNA synthetase [Cyanobacteria bacterium Yellowstone A-Prime] gi\|86554901, gi\|... - gi\|86606359\|ref\|YP_475122.1\| isoleucyl-tRNA synthetase [Synechococcus sp. JA-3-3Ab], gi\|86554901\|gb\|...	785.0	[0..32]	[969..1]
gi\|196253626, gi... - gi\|196253626\|ref\|ZP_03152245.1\| isoleucyl-tRNA synthetase [Clostridium thermocellum DSM 4150], gi\|19... gi\|67849228, gi\|... - gi\|67916806\|ref\|ZP_00510499.1\| Isoleucyl-tRNA synthetase, class Ia [Clostridium thermocellum ATCC 27...	783.0	[0..32]	[968..3]
gi\|98660860, gi\|... - gi\|98660860\|dbj\|GAA02023.1\| unnamed protein product [Pelotomaculum thermopropionicum SI], gi\|1476781...	783.0	[0..29]	[971..1]
SYI_DESHD - Isoleucine--tRNA ligase OS=Desulfitobacterium hafniense (strain DCB-2 / DSM 10664) GN=ileS PE=3 SV=1	778.0	[0..32]	[971..1]
SYI_SYNWW - Isoleucine--tRNA ligase OS=Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen) GN=il...	778.0	[0..29]	[972..1]
SYI_DESHY - Isoleucine--tRNA ligase OS=Desulfitobacterium hafniense (strain Y51) GN=ileS PE=3 SV=1	778.0	[0..32]	[971..1]

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Predicted Domain #1

Region A:
Residues: [1-973]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKFSYISSLP KGHNHICCKQ AGRFLSSQAD LKKYSESLCL PKTSFPIKPN VKGNNEKYFK  60
   61 SITSDLYEWQ KENLNKEDSF VLLDGPPFAN GRLHIGHALN KILKDIINRW QLLKGRSVHY 120
  121 VPGWDCHGLP IESKAIKANA ERKSSLEIRK IAKDFANSAV QEQLMMFQRM AVMGDWPSRY 180
  181 ITMSDKFEIA ELKVFLSLLQ KDLIFRQNKP VYWSSSSRSA LAESEIEYDD NHVSTSIYFT 240
  241 FPVNSFSIDG CEYNNVKALV WTTTPWTIPS NLALSYHPEI NYGLYQHNNS IYLMSDNLVP 300
  301 NLDFMQGAKR LASCPSDIIS SFTYENPLLP KQSFPFLQSN YVTNDIGTGI VHVAPGHGME 360
  361 DYLLGLENNL RPFSPLDDYG RYTKEALDGS LEGLEVLGDG GKKVISIMKN QNMIVKVSPY 420
  421 KHRYPYDWRT HKPLILRATP QWFISLENER KTAIKALDSV KMIPPNSRAR LLGFLNGRPE 480
  481 WCISRQRAWG LPIPVLYEKG TKIPLLTVKS VSYIIEKMEV EGVDSWFNDT ENNGHAQWVH 540
  541 PDYRNKEYIR GTETLDVWFD SGTSWTTIAP RKNKPLIDLC LEGSDQHRGW FQSLLLTYTA 600
  601 YQSKPEAPFS TLFTHGFIFD ERGQKQSKSL GNVTDPEDVI NGKLLKGKKL PYGVDLLRLW 660
  661 VASCDSTNDT NLGPNILTQV GESLKKWRLT SRFCLGNLHD WNTSSSVDVG ELRGIDKLAL 720
  721 VQLDKFQTEI RELYESYSIN KVVHHLNYFM NSFLSSTYFD AVKDRLYADL PNSVSRRSVQ 780
  781 TVLYHSLLTL IWAISPITPL LAQEIWQSLP DSYLNSSYQT PFHAGETHLI SSLRSKVDLL 840
  841 DRKFLIKEYL VLQQLKYSIN LLITAARENL TIKNSLEAYV VIKSKSQSLL SFLKNYSSDL 900
  901 PFLFNTSKVF INEIPENLKL ASVTQPEVQL DYGVANISLF FSNQQKCLRC WMHTAHEDGL 960
  961 CDRCESVLAQ LKR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1ffyA
Description:	Isoleucyl-tRNA synthetase (IleRS)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ligase activity, forming aminoacyl-tRNA and related compounds	7.16276509815667	bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds	7.16276509815667	bayes_pls_golite062009
aminoacyl-tRNA ligase activity	7.13957775963187	bayes_pls_golite062009
valine-tRNA ligase activity	7.13767629265822	bayes_pls_golite062009
isoleucine-tRNA ligase activity	6.38633897147986	bayes_pls_golite062009
ligase activity	6.11211476973434	bayes_pls_golite062009
glutamate-tRNA ligase activity	2.63681738794687	bayes_pls_golite062009
leucine-tRNA ligase activity	2.62601062778624	bayes_pls_golite062009
methionine-tRNA ligase activity	2.56893064485672	bayes_pls_golite062009
catalytic activity	2.37674226834122	bayes_pls_golite062009
tyrosine-tRNA ligase activity	1.88984817882585	bayes_pls_golite062009
arginine-tRNA ligase activity	1.50161401062914	bayes_pls_golite062009
tryptophan-tRNA ligase activity	1.14187887833901	bayes_pls_golite062009
cysteine-tRNA ligase activity	0.844943947059557	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.625793556381714	bayes_pls_golite062009
binding	0.485102284225571	bayes_pls_golite062009
nucleic acid binding	0.449504767632354	bayes_pls_golite062009
nucleotidyltransferase activity	0.2293846471193	bayes_pls_golite062009
glutamine-tRNA ligase activity	0.118292082006187	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: