YRC Public Data Repository - Protein Structure Prediction

Protein:	SPBC887.18c
Organism:	Schizosaccharomyces pombe
Length:	339 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPBC887.18c.

Description	E-value	Query Range	Subject Range
gi\|1145779 - gi\|1145779\|gb\|AAA84983.1\| Hfi1p	336.0	[0..11]	[326..50]
gi\|28922500, gi\|... - gi\|32406094\|ref\|XP_323660.1\| predicted protein [Neurospora crassa], gi\|28922500\|gb\|EAA31730.1\| hypot... gi\|85100450 - gi\|85100450\|ref\|XP_960966.1\| hypothetical protein NCU04320 [Neurospora crassa OR74A]	310.0	[0..2]	[268..25]
gi\|28950180 - gi\|28950180\|emb\|CAD71048.1\| related to transcriptional coactivator HFI1 [Neurospora crassa]	306.0	[0..2]	[268..25]
gi\|38110449, gi\|... - gi\|39952343\|ref\|XP_363888.1\| hypothetical protein MGG_01814 [Magnaporthe grisea 70-15], gb\|EAA56163....	304.0	[0..1]	[258..23]
gi\|46136787, gi\|... - gi\|46136787\|ref\|XP_390085.1\| hypothetical protein FG09909.1 [Gibberella zeae PH-1], gi\|42547292\|gb\|E...	293.0	[0..8]	[264..33]
gi\|67900922, gi\|... - gi\|67900922\|ref\|XP_680717.1\| hypothetical protein AN7448.2 [Aspergillus nidulans FGSC A4], ref\|XP_41...	286.0	[0..7]	[257..1575]
gi\|45198350, gi\|... - gi\|45198350\|ref\|NP_985379.1\| AFL171Wp [Ashbya gossypii ATCC 10895], gi\|44984237\|gb\|AAS53203.1\| AFL17... gi\|44984237 - gi\|44984237\|gb\|AAS53203.1\| AFL171Wp [Ashbya gossypii ATCC 10895]	280.0	[0..17]	[281..48]
orf19.307, orf19... - orf19.307 CGDID:CAL0004632 Assembly 19, Contig19-10046 (133186, 131714) CDS, reverse complemented, t... gi\|68471918, gi\|... - gi\|68471918\|ref\|XP_720002.1\| hypothetical protein CaO19.307 [Candida albicans SC5314], gi\|68471655\|r...	279.0	[0..12]	[280..43]
gi\|169769486 - gi\|169769486\|ref\|XP_001819213.1\| hypothetical protein [Aspergillus oryzae RIB40] gi\|83767071 - gi\|83767071\|dbj\|BAE57211.1\| unnamed protein product [Aspergillus oryzae]	256.0	[0..15]	[257..37]

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Predicted Domain #1

Region A:
Residues: [1-134]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTEGVTVQKV QSASSNGHKP NTVISQIISE MQSLLGSSFE VYTKTMTDFL IGQLSRKEMK  60
   61 SMLLTFAGKS NFDKLHNSII FHILKLMQKN NDTFSALHHL PWFKRKKVDN SLFLHKKISS 120
  121 QNAQVRLIKR IVMS

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.419	0.524	histone acetylation	c.55.1	Actin-like ATPase domain
View	Download	0.375	0.214	protein binding, bridging	a.1.1	Globin-like
View	Download	0.366	0.033	protein binding, bridging	d.80.1	Tautomerase/MIF
View	Download	0.309	N/A	N/A	d.54.1	Enolase N-terminal domain-like
View	Download	0.299	N/A	N/A	a.1.1	Globin-like

Predicted Domain #2

Region A:
Residues: [135-191]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSYKDRARIK TALKEKPVTP SLISGLLLET RIAKLPKIPV SRDKLNSVFV NDIKAGY

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.517	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.423	a.55.1	IHF-like DNA-binding proteins
View	Download	0.471	a.60.6	DNA polymerase beta, N-terminal domain-like
View	Download	0.451	a.60.6	DNA polymerase beta, N-terminal domain-like
View	Download	0.437	a.4.5	"Winged helix" DNA-binding domain

Predicted Domain #3

Region A:
Residues: [192-339]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VAPLACETLE LPDSESLKER ITAISLENGL LGGVQKGVSD IILAGLESHL KNILSRCFSI  60
   61 LNKNIRQKNT ENDAAGFTIN DLNLAWTIEP HAFVEQYPQK LRMPFLLHDS YTEDEISICA 120
  121 ESPSYMLASN DAQSDRNSVA SLLDEVLS

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	0.976
Match:	1h3oA
Description:	TAF(II)-135, (TAF(II)-130, hTAF4), histone fold domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
histone acetyltransferase activity	5.93249134612505	bayes_pls_golite062009
lysine N-acetyltransferase activity	5.93249134612505	bayes_pls_golite062009
N-acetyltransferase activity	4.49084162254966	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	4.4864586197085	bayes_pls_golite062009
N-acyltransferase activity	4.2172829451557	bayes_pls_golite062009
DNA binding	4.00167809338753	bayes_pls_golite062009
transcription regulator activity	3.91807454227165	bayes_pls_golite062009
acetyltransferase activity	3.91533222675137	bayes_pls_golite062009
nucleic acid binding	3.72299085850948	bayes_pls_golite062009
binding	3.67149228723241	bayes_pls_golite062009
acyltransferase activity	3.38996237245502	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	3.35419529667223	bayes_pls_golite062009
transferase activity, transferring acyl groups	3.18312128320637	bayes_pls_golite062009
RNA polymerase II transcription factor activity	3.02428691626433	bayes_pls_golite062009
transcription factor activity	2.18855864512878	bayes_pls_golite062009
transcription initiation factor activity	1.61443429710414	bayes_pls_golite062009
protein binding	1.22636497573761	bayes_pls_golite062009
transcription activator activity	1.12739348005764	bayes_pls_golite062009
transcription factor binding	1.01773884290535	bayes_pls_golite062009
transcription coactivator activity	0.976797801726735	bayes_pls_golite062009
transcription cofactor activity	0.840442755533537	bayes_pls_golite062009
transcription repressor activity	0.621482805601238	bayes_pls_golite062009
histone binding	0.184823910505751	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.126825123711624	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: