YRC Public Data Repository - Protein Structure Prediction

Protein:	SPBC29A3.13
Organism:	Schizosaccharomyces pombe
Length:	359 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPBC29A3.13.

Description	E-value	Query Range	Subject Range
PDP3_SCHPO - PWWP domain-containing protein 3 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=pdp3 PE=1... SPAC23D3.01 - PWWP domain protein	182.0	[0..4]	[350..4]
gi\|38104025, gi\|... - gi\|39944854\|ref\|XP_361964.1\| hypothetical protein MG04409.4 [Magnaporthe grisea 70-15], gb\|EAA50650....	165.0	[0..9]	[353..64]
gi\|46097825, gi\|... - gi\|71022201\|ref\|XP_761331.1\| hypothetical protein UM05184.1 [Ustilago maydis 521], ref\|XP_402799.1\| ...	160.0	[0..32]	[352..2]
gi\|45190343, gi\|... - gi\|45190343\|ref\|NP_984597.1\| AEL263Cp [Ashbya gossypii ATCC 10895], gi\|44983239\|gb\|AAS52421.1\| AEL26... gi\|44983239 - gi\|44983239\|gb\|AAS52421.1\| AEL263Cp [Ashbya gossypii ATCC 10895]	160.0	[0..47]	[350..3]
YLR455W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to th... YL455_YEAST - PWWP domain-containing protein YLR455W OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=Y...	158.0	[0..48]	[351..3]
gi\|114619715, gi... - gi\|114619719\|ref\|XP_001170815.1\| PREDICTED: WHSC1L1 protein isoform 5 [Pan troglodytes], gi\|11461971...	148.0	[0..5]	[248..191]

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Predicted Domain #1

Region A:
Residues: [1-198]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNNARTNAKR RRLSSKQGGL SISEGKESNI PSVVEESKDN LEQASADDRL NFGDRILVKA  60
   61 PGYPWWPALL LRRKETKDSL NTNSSFNVLY KVLFFPDFNF AWVKRNSVKP LLDSEIAKFL 120
  121 GSSKRKSKEL IEAYEASKTP PDLKEESSTD EEMDSLSAAE EKPNFLQKRK YHWETSLDES 180
  181 DAESISSGSL MSITSISE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	19.69897
Match:	1khcA
Description:	DNA methyltransferase DNMT3B
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
histone methyltransferase activity	4.99595771339053	bayes_pls_golite062009
protein methyltransferase activity	4.19447715401381	bayes_pls_golite062009
histone-lysine N-methyltransferase activity	4.17343835151493	bayes_pls_golite062009
protein-lysine N-methyltransferase activity	4.17343835151493	bayes_pls_golite062009
lysine N-methyltransferase activity	4.17343835151493	bayes_pls_golite062009
methylated histone residue binding	3.99360930536438	bayes_pls_golite062009
DNA (cytosine-5-)-methyltransferase activity	3.47194555232584	bayes_pls_golite062009
DNA-methyltransferase activity	3.07442486638326	bayes_pls_golite062009
binding	3.03932294945523	bayes_pls_golite062009
transcription regulator activity	2.54859161354698	bayes_pls_golite062009
histone binding	2.53075587257882	bayes_pls_golite062009
unmethylated CpG binding	2.40629601442755	bayes_pls_golite062009
N-methyltransferase activity	2.35081504375623	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	2.18489564426455	bayes_pls_golite062009
histone methyltransferase activity (H3-K36 specific)	1.77912558508065	bayes_pls_golite062009
protein binding	1.76914488602752	bayes_pls_golite062009
DNA binding	1.74895470739534	bayes_pls_golite062009
nucleic acid binding	1.72728430471046	bayes_pls_golite062009
methyltransferase activity	1.45012620929102	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	1.37282797213354	bayes_pls_golite062009
histone methyltransferase activity (H4-K20 specific)	1.33068639111811	bayes_pls_golite062009
transcription repressor activity	1.29059770639777	bayes_pls_golite062009
transcription factor binding	1.24998724455481	bayes_pls_golite062009
transcription cofactor activity	1.07648674416752	bayes_pls_golite062009
estrogen receptor binding	1.07290804941322	bayes_pls_golite062009
transcription factor activity	0.865067316865618	bayes_pls_golite062009
chromatin binding	0.50732149810757	bayes_pls_golite062009
transcription corepressor activity	0.0798851485729806	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [199-278]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYGPTVASTS RSSTQLSDQR YPLSSNFDHR GEAKGKGKQP LKNPQERGRI SPSSPLNDQT  60
   61 KALMQRLLFF RHKLQKAFLS

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [279-359]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PDHLIVEEDF YNASKYLNAI SDIPFLNYEL ITSTKLAKVL KRIAFLEHLE NDELYDIRQK  60
   61 CKNLLYSWAM FLPNEPSIKG M

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.23
Match:	1wjtA
Description:	Solution structure of the N-terminal Domain I of mouse transcription elongation factor S-II protein 3
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: