YRC Public Data Repository - Protein Structure Prediction

Protein:	SPBC29A3.13
Organism:	Schizosaccharomyces pombe
Length:	359 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPBC29A3.13.

Description	E-value	Query Range	Subject Range
PDP3_SCHPO - PWWP domain-containing protein 3 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=pdp3 PE=1... SPAC23D3.01 - PWWP domain protein	182.0	[0..4]	[350..4]
gi\|38104025, gi\|... - gi\|39944854\|ref\|XP_361964.1\| hypothetical protein MG04409.4 [Magnaporthe grisea 70-15], gb\|EAA50650....	165.0	[0..9]	[353..64]
gi\|46097825, gi\|... - gi\|71022201\|ref\|XP_761331.1\| hypothetical protein UM05184.1 [Ustilago maydis 521], ref\|XP_402799.1\| ...	160.0	[0..32]	[352..2]
gi\|45190343, gi\|... - gi\|45190343\|ref\|NP_984597.1\| AEL263Cp [Ashbya gossypii ATCC 10895], gi\|44983239\|gb\|AAS52421.1\| AEL26... gi\|44983239 - gi\|44983239\|gb\|AAS52421.1\| AEL263Cp [Ashbya gossypii ATCC 10895]	160.0	[0..47]	[350..3]
YLR455W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to th... YL455_YEAST - PWWP domain-containing protein YLR455W OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=Y...	158.0	[0..48]	[351..3]
gi\|114619715, gi... - gi\|114619719\|ref\|XP_001170815.1\| PREDICTED: WHSC1L1 protein isoform 5 [Pan troglodytes], gi\|11461971...	148.0	[0..5]	[248..191]

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Predicted Domain #1

Region A:
Residues: [1-198]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNNARTNAKR RRLSSKQGGL SISEGKESNI PSVVEESKDN LEQASADDRL NFGDRILVKA  60
   61 PGYPWWPALL LRRKETKDSL NTNSSFNVLY KVLFFPDFNF AWVKRNSVKP LLDSEIAKFL 120
  121 GSSKRKSKEL IEAYEASKTP PDLKEESSTD EEMDSLSAAE EKPNFLQKRK YHWETSLDES 180
  181 DAESISSGSL MSITSISE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	19.69897
Match:	1khcA
Description:	DNA methyltransferase DNMT3B
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
histone methyltransferase activity	4.99595771339053	bayes_pls_golite062009
protein methyltransferase activity	4.19447715401381	bayes_pls_golite062009
histone-lysine N-methyltransferase activity	4.17343835151493	bayes_pls_golite062009
protein-lysine N-methyltransferase activity	4.17343835151493	bayes_pls_golite062009
lysine N-methyltransferase activity	4.17343835151493	bayes_pls_golite062009
methylated histone residue binding	3.99360930536438	bayes_pls_golite062009
DNA (cytosine-5-)-methyltransferase activity	3.47194555232584	bayes_pls_golite062009
DNA-methyltransferase activity	3.07442486638326	bayes_pls_golite062009
binding	3.03932294945523	bayes_pls_golite062009
transcription regulator activity	2.54859161354698	bayes_pls_golite062009
histone binding	2.53075587257882	bayes_pls_golite062009
unmethylated CpG binding	2.40629601442755	bayes_pls_golite062009
N-methyltransferase activity	2.35081504375623	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	2.18489564426455	bayes_pls_golite062009
histone methyltransferase activity (H3-K36 specific)	1.77912558508065	bayes_pls_golite062009
protein binding	1.76914488602752	bayes_pls_golite062009
DNA binding	1.74895470739534	bayes_pls_golite062009
nucleic acid binding	1.72728430471046	bayes_pls_golite062009
methyltransferase activity	1.45012620929102	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	1.37282797213354	bayes_pls_golite062009
histone methyltransferase activity (H4-K20 specific)	1.33068639111811	bayes_pls_golite062009
transcription repressor activity	1.29059770639777	bayes_pls_golite062009
transcription factor binding	1.24998724455481	bayes_pls_golite062009
transcription cofactor activity	1.07648674416752	bayes_pls_golite062009
estrogen receptor binding	1.07290804941322	bayes_pls_golite062009
transcription factor activity	0.865067316865618	bayes_pls_golite062009
chromatin binding	0.50732149810757	bayes_pls_golite062009
transcription corepressor activity	0.0798851485729806	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [199-278]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYGPTVASTS RSSTQLSDQR YPLSSNFDHR GEAKGKGKQP LKNPQERGRI SPSSPLNDQT  60
   61 KALMQRLLFF RHKLQKAFLS

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [279-359]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PDHLIVEEDF YNASKYLNAI SDIPFLNYEL ITSTKLAKVL KRIAFLEHLE NDELYDIRQK  60
   61 CKNLLYSWAM FLPNEPSIKG M

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.23
Match:	1wjtA
Description:	Solution structure of the N-terminal Domain I of mouse transcription elongation factor S-II protein 3
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: