YRC Public Data Repository - Protein Structure Prediction

Protein:	SPBP8B7.17c
Organism:	Schizosaccharomyces pombe
Length:	506 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPBP8B7.17c.

Description	E-value	Query Range	Subject Range
gi\|46116572, gi\|... - gi\|46116572\|ref\|XP_384304.1\| hypothetical protein FG04128.1 [Gibberella zeae PH-1], gi\|42549487\|gb\|E...	422.0	[0..4]	[503..5]
SPBP8B7.18c - phosphomethylpyrimidine kinase THI22_SCHPO - Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 2 OS=Schizosaccharomyces pombe (stra...	412.0	[0..2]	[499..35]
gi\|159129479 - gi\|159129479\|gb\|EDP54593.1\| thiamin biosynthesis protein (Thi-4), putative [Aspergillus fumigatus A1... gi\|71001452, gi\|... - gi\|71001452\|ref\|XP_755407.1\| thiamin biosynthesis protein (Thi-4) [Aspergillus fumigatus Af293], gi\|...	390.0	[0..2]	[499..3]
gi\|115384640, gi... - gi\|115384640\|ref\|XP_001208867.1\| hypothetical protein ATEG_01502 [Aspergillus terreus NIH2624], gi\|1...	382.0	[0..24]	[499..19]
gi\|119178042, gi... - gi\|90299515\|gb\|EAS29146.1\| hypothetical protein CIMG_07892 [Coccidioides immitis RS], gi\|119178042\|r...	382.0	[0..2]	[502..4]
gi\|40738605, gi\|... - gi\|67539524\|ref\|XP_663536.1\| hypothetical protein AN5932.2 [Aspergillus nidulans FGSC A4], ref\|XP_41...	372.0	[0..36]	[499..1522]
gi\|50552113, gi\|... - gi\|50552113\|ref\|XP_503531.1\| YALI0E04224p [Yarrowia lipolytica], gi\|49649400\|emb\|CAG79112.1\| unnamed... gi\|49649400 - gi\|49649400\|emb\|CAG79112.1\| YALI0E04224p [Yarrowia lipolytica]	363.0	[0..3]	[501..7]
gi\|4432914, gi\|1... - gi\|4432914\|dbj\|BAA21049.1\| thiamine-4 [Neurospora crassa], pir\|\|T47257 thiamin biosynthesis protein ...	362.0	[0..2]	[469..11]
gi\|32416154, gi\|... - gi\|32416154\|ref\|XP_328555.1\| hypothetical protein [Neurospora crassa], gi\|28924762\|gb\|EAA33874.1\| hy... gi\|85109833 - gi\|85109833\|ref\|XP_963110.1\| hypothetical protein [Neurospora crassa OR74A]	362.0	[0..2]	[498..11]
gi\|38106262, gi\|... - gi\|39939910\|ref\|XP_359492.1\| hypothetical protein MG05285.4 [Magnaporthe grisea 70-15], gb\|EAA52593....	357.0	[0..34]	[489..1]

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Predicted Domain #1

Region A:
Residues: [1-283]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MISTCITVAG SDCSGGAGVQ ADLKVFTAHS VYGMSAVTAI TSQNTIGVNG VHLIPASYVE  60
   61 QQISACLLDV HCEVMKTGML FNQQILKVIV ESIDRFKIKK VVVDPLIATR KGALLVMPDY 120
  121 LELFVKELIP RAEVLIPNIA EALIILKHMT NEFVEIHHLE DVKAVGKKLI KAGCKNVVIR 180
  181 CDDIPFASDF FCSRETNMPP TWYLYVLCTS EGEVLLPQKW LASKTARGTS CALSSAVASN 240
  241 LAIGLDLVTA TQNAVSYTQR ALEMSFHLGR GANSLDYASA LTR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	57.154902
Match:	1jxhA
Description:	4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate kinase (HMP-phosphate kinase, ThiD)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphomethylpyrimidine kinase activity	3.972577109569	bayes_pls_golite062009
carbohydrate kinase activity	2.34445983129813	bayes_pls_golite062009
thiaminase activity	2.33383885490808	bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor	2.29466565429735	bayes_pls_golite062009
kinase activity	2.28531824242987	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	2.27980720248925	bayes_pls_golite062009
transferase activity	2.15883296431019	bayes_pls_golite062009
catalytic activity	1.74474587246986	bayes_pls_golite062009
hydroxyethylthiazole kinase activity	1.28568044601242	bayes_pls_golite062009
thiamin-phosphate diphosphorylase activity	1.27602595951972	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.673555832721854	bayes_pls_golite062009
phosphofructokinase activity	0.37205329607884	bayes_pls_golite062009
nucleic acid binding	0.35385659578167	bayes_pls_golite062009
binding	0.2717506679077	bayes_pls_golite062009
transcription regulator activity	0.219913271321955	bayes_pls_golite062009
pyridoxal kinase activity	0.217863391052366	bayes_pls_golite062009
DNA binding	0.101423482181266	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [284-506]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPYEKGEFIN FVRYHPSITP KWLSIVNHPF VEQLKAGTLS RLPFQKYLVL KYHMLINNAQ  60
   61 AAGMMAFSSS SISAIEHSAK IIQAIKEENV THLRICEQYG LSASQITKSK PEIVKSHSLF 120
  121 IHDTAQQDGL RGIQIAMLPF VFMIQEVVSQ ISASDGYPYV AWVEHCKDKS ATSHIETLLE 180
  181 SLETNSQIIS LSKVQHLLGI LEKSLDFERL VLDTSSSNES SVF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	54.0
Match:	1yafA
Description:	Structure of TenA from Bacillus subtilis
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	0.653486090379666	bayes_pls_golite062009
catalytic activity	0.476060647762462	bayes_pls_golite062009
transcription regulator activity	0.37460460006397	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: