YRC Public Data Repository - Protein Structure Prediction

Protein:	lub1
Organism:	Schizosaccharomyces pombe
Length:	713 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for lub1.

Description	E-value	Query Range	Subject Range
gi\|186464325, gi... - gi\|23128981\|ref\|ZP_00110817.1\| COG2319: FOG: WD40 repeat [Nostoc punctiforme PCC 73102], gi\|18668187...	557.0	[0..7]	[603..1165]
YY46_NOSS1 - Uncharacterized WD repeat-containing protein alr3466 OS=Nostoc sp. (strain PCC 7120 / UTEX 2576) GN=... gi\|25530855 - pir\|\|AC2239 WD-40 repeat protein [imported] - Nostoc sp. (strain PCC 7120)	545.0	[0..3]	[581..895]
gi\|37523925, gi\|... - gi\|37523925\|ref\|NP_927302.1\| WD repeat-containing protein [Gloeobacter violaceus PCC 7421], gi\|35214...	541.0	[0..1]	[535..597]
gi\|148658115, gi... - gi\|148658115\|ref\|YP_001278320.1\| NB-ARC domain-containing protein [Roseiflexus sp. RS-1], gi\|1485702...	534.0	[0..2]	[573..935]
gi\|75701503, gi\|... - gi\|75907778\|ref\|YP_322074.1\| ribosome assembly protein 4 (RSA4) [Anabaena variabilis ATCC 29413], gi...	534.0	[0..7]	[607..1037]
gi\|115443476, gi... - gi\|115443476\|ref\|XP_001218545.1\| hypothetical protein ATEG_09923 [Aspergillus terreus NIH2624], gi\|1...	524.0	[0..7]	[571..641]
gi\|48893630, gi\|... - gi\|71673807\|ref\|ZP_00671555.1\| TPR repeat:G-protein beta WD-40 repeat:YD repeat [Trichodesmium eryth...	523.0	[0..2]	[548..983]

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Predicted Domain #1

Region A:
Residues: [1-84]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSYELSREL GGHKQDVRGV CSISNELIGS ASRDGTYSVW EQINGEWTPH FYENHEGFVN  60
   61 CVCYVPAIDK NSRGGQDKCG ILQE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	64.522879
Match:	2ovpB
Description:	No description for 2ovpB was found.

Predicted Domain #2

Region A:
Residues: [85-213]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VGTNSPSYYL FGHESNICSA SALNSETIIT GSWDSTARVW ALGQCKYVLK GHQSSVWAVL  60
   61 ALGEDIFITG SADKLIKIWN GEKLVKSILA HNDCVRSLCQ IPGGFASCSN DGVIKLWTSD 120
  121 GEFLYELHG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	4.154902
Match:	1l0qA
Description:	Surface layer protein
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [214-544]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HTSFVYSLTY IHNQQLIASC GEDRTIRIWK GKECLQCITL PTTSVWSVSS LPNGDLVCGS  60
   61 SDGFVRIFTV DKVRVAPTEV LKNFEERVSQ FAISSQEVGD IKKGSLPGLE ILSKPGKADG 120
  121 DVVMVRVNND VEAYQWSQKE NEWKKIGQVV DAVGNNRKQL FEGKEYDYVF DVDVADGQAP 180
  181 LKLPYNATEN PYQAANRFLE LNQLPLSYTD EVVKFIEKNT QGHSLESKKE PNLESQSSNK 240
  241 IKTTIFPVSQ LLFSNANVPA MCQRLRSLNN TKSNPLPAKS IDSLERALSS KKITDTEKNE 300
  301 LLETCLSILD SWSLAERFPA LDALRLLAIN S

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	11.69897
Match:	1s4uX
Description:	Crystal Structure analysis of the beta-propeller protein Ski8p
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ubiquitin-protein ligase activity	3.10232773079579	bayes_pls_golite062009
small conjugating protein ligase activity	2.89805111479917	bayes_pls_golite062009
binding	2.42570478946173	bayes_pls_golite062009
protein binding	2.26925404328312	bayes_pls_golite062009
acid-amino acid ligase activity	2.01595241503145	bayes_pls_golite062009
cytoskeletal protein binding	0.900963766598159	bayes_pls_golite062009
nucleic acid binding	0.879332537553732	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	0.734230328744066	bayes_pls_golite062009
actin binding	0.708446291495757	bayes_pls_golite062009
histone binding	0.685319917508843	bayes_pls_golite062009
transcription regulator activity	0.579815310385678	bayes_pls_golite062009
histone methyltransferase activity	0.311523647180993	bayes_pls_golite062009
DNA binding	0.296423033247139	bayes_pls_golite062009
protein kinase activity	0.229242350006544	bayes_pls_golite062009
chromatin binding	0.145491963066342	bayes_pls_golite062009
phospholipase A2 activator activity	0.0696962213283392	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [545-713]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSDLAPIFLE VFSRVVKSVP SSGNFESINV MLALRGLSNV VPNITDAEGV SKLMDCLTST  60
   61 VPQASSAKDF KIAFATLAMN LSILLIQLNL ENTGIELLSI LFSFLDDPSP DNEAFYRALM 120
  121 ALGTLCTVPD IALAASQIYH AQSIVHGIAE RFSQEMRFVD AEKQILSLF

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	6.585027
Match:	PF08324.2
Description:	No description for PF08324.2 was found.

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.605	0.112	histone ubiquitination	a.100.1	6-phosphogluconate dehydrogenase C-terminal domain-like
View	Download	0.548	0.072	histone ubiquitination	a.74.1	Cyclin-like
View	Download	0.681	0.027	histone ubiquitination	a.24.10	Histidine-containing phosphotransfer domain, HPT domain
View	Download	0.672	0.009	histone ubiquitination	a.7.6	Ribosomal protein S20
View	Download	0.656	N/A	N/A	f.35.1	Multidrug efflux transporter AcrB transmembrane domain

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: