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View Structure Prediction Details

Protein: SPBC21B10.13c
Organism: Schizosaccharomyces pombe
Length: 201 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPBC21B10.13c.

Description E-value Query
Range
Subject
Range
gi|9621907 - gi|9621907|gb|AAF89581.1|AF165886_1 paired-box transcription factor [Branchiostoma floridae]
121.0 [0..14] [197..170]
gi|8920423, gi|1... - gi|8920423|emb|CAB96423.1| OCL3 protein [Zea mays], gi|162462506|ref|NP_001105125.1| outer cell laye...
118.0 [0..7] [200..94]
gi|15823130 - gi|15823130|dbj|BAB68716.1| homeobox protein [Mus musculus musculus]
tr|Q920T7|Q920T7... - tr|Q920T7|Q920T7_MOUSE Homeobox protein (Fragment) OS=Mus musculus GN=Hoxa2 PE=2 SV=1, Homeobox prot...
116.0 [0..27] [199..7]
gi|15823132 - gi|15823132|dbj|BAB68717.1| homeobox protein [Mus spicilegus]
gi|15823120, gi|... - gi|15823128|dbj|BAB68715.1| homeobox protein [Mus musculus], gi|15823126|dbj|BAB68714.1| homeobox pr...
gi|15823118 - gi|15823118|dbj|BAB68710.1| homeobox protein [Mus musculus musculus]
116.0 [0..27] [199..7]
gi|33339721, gi|... - gi|45383171|ref|NP_989830.1| transcription factor Crx [Gallus gallus], gi|33339721|gb|AAQ14340.1|AF2...
116.0 [0..14] [198..19]
gi|114583567 - gi|114583567|ref|XP_001165353.1| PREDICTED: paired box gene 3 isoform 5 [Pan troglodytes]
114.0 [0..7] [193..198]
gi|38636822, gi|... - gi|50940895|ref|XP_479975.1| putative OCL5 protein [Oryza sativa (japonica cultivar-group)], gi|4639...
113.0 [0..1] [197..134]
gi|109101200 - gi|109101200|ref|XP_001107509.1| PREDICTED: paired box gene 3 (Waardenburg syndrome 1) isoform 5 [Ma...
113.0 [0..7] [193..193]

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Predicted Domain #1
Region A:
Residues: [1-103]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLSDSPSKS GNTGKDLISN NEAKNHEDEE THQKKRRRRT TDAEATLLEQ YFLKTPKPSL  60
   61 IERQELSKKL KSSMTPRELQ IWFQNKRQSL RRSNCLSRNR LEG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.69897
Match: 1pufA
Description: Crystal Structure of HoxA9 and Pbx1 homeodomains bound to DNA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.41271657675151 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.26183812259792 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
transcription activator activity 1.77700860354597 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.14886080629275 bayes_pls_golite062009
chromatin binding 1.04132983826241 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [104-201]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TGENSLLRRK STLTLCETST GQAELFFQSW PLHSQSVVGE MIHHEQDDYN KENKQQKVVD  60
   61 TTKDISRGSN GNEDSAAHQE LEECARSLVE LQQQCNDH

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.506 0.526 transcription factor activity a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.551 0.232 regulation of transcription, DNA-dependent a.29.2 Bromodomain
View Download 0.540 0.000 transcription factor activity d.87.2 CO dehydrogenase flavoprotein C-terminal domain-like
View Download 0.727 0.000 transcription factor activity a.60.10 Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain
View Download 0.540 N/A N/A a.29.2 Bromodomain


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle