YRC Public Data Repository - Protein Structure Prediction

Protein:	vma13
Organism:	Schizosaccharomyces pombe
Length:	450 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for vma13.

Description	E-value	Query Range	Subject Range
VhaSFD-PA, FBpp0... - The gene Vacuolar H<sup>+</sup>-ATPase SFD subunit is referred to in FlyBase by the symbol Dmel\VhaS... gi\|220956206, gi... - gi\|220956206\|gb\|ACL90646.1\| VhaSFD-PA [synthetic construct], gi\|220946536\|gb\|ACL85811.1\| VhaSFD-PA [...	549.0	[0..20]	[440..17]
gi\|58379986, gi\|... - gi\|58379986\|ref\|XP_310211.2\| ENSANGP00000011012 [Anopheles gambiae str. PEST], gi\|55244097\|gb\|EAA058...	547.0	[0..20]	[440..4]
gi\|54644870, gi\|... - gi\|54644870\|gb\|EAL33610.1\| GA14464-PA [Drosophila pseudoobscura], gi\|125985565\|ref\|XP_001356546.1\| G...	545.0	[0..20]	[440..17]
gi\|108877664, gi... - gi\|157113604\|ref\|XP_001652018.1\| vacuolar ATP synthase subunit h [Aedes aegypti], gi\|108877664\|gb\|EA...	541.0	[0..20]	[440..21]
gi\|91088299 - gi\|91088299\|ref\|XP_966693.1\| PREDICTED: similar to CG17332-PA, isoform A isoform 1 [Tribolium castan...	541.0	[0..20]	[440..31]
gi\|47717100, gi\|... - gi\|47717100\|ref\|NP_998784.1\| ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H isoform 2 [Ho...	535.0	[0..27]	[440..22]
gi\|55730321 - gi\|55730321\|emb\|CAH91883.1\| hypothetical protein [Pongo abelii] gi\|197101837 - gi\|197101837\|ref\|NP_001126091.1\| ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H [Pongo ab...	533.0	[0..27]	[440..22]
gi\|47937977, gi\|... - gi\|47937977\|gb\|AAH71441.1\| ATPase, H+ transporting, lysosomal, V1 subunit H [Danio rerio], gi\|375903...	533.0	[0..27]	[440..19]

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Predicted Domain #1

Region A:
Residues: [1-450]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNSDLELSN AASPPPVELD NSQVDEIINN VRCVAIPWQG YQRSGSLEEN ELQEIENLTG  60
   61 KPLSAYVKTA EEDTTAYSNL FLKLLSMKDT PDVVNFALVK LADTLLNSNK FLSAFGPAFY 120
  121 DFLEKDESYI NYLDDDSKLL FARVFALCSS SSPCSVAKAF TLFLEYLGKL MQSLNPLTRL 180
  181 FAVQCLNGVL TLKAHRYALW AENTCSFRLA ELLRNSIGDT QLQYYSLFCF WQLTFESHIA 240
  241 QDINKRFDLI KLLVQIIRSD TKTKVYRLVL AILVNLIDKA PKDTISTMLL EHVDKAVQLL 300
  301 QKRKWADEDI TNYLDFITST LDESSKHLST FDMYKSELDT GILHWSPSHR SEDFWHQNAK 360
  361 RLNEDNYALL KKLFHIVQYN EDNTSLAVAC HDLGAYIRSY PEGRSLIIKY GAKQRIMDLM 420
  421 SHPDPEVRFE ALSTVQLLMT EVCFLSKITL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	97.045757
Match:	1ho8A
Description:	Regulatory subunit H of the V-type ATPase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
hydrogen ion transmembrane transporter activity	8.27793692177437	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	6.61991113486273	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	5.91856058767561	bayes_pls_golite062009
proton-transporting ATPase activity, rotational mechanism	3.08652472111805	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	3.01705909078235	bayes_pls_golite062009
ion transmembrane transporter activity	2.62570967627286	bayes_pls_golite062009
cation transmembrane transporter activity	2.5665080711484	bayes_pls_golite062009
transporter activity	2.48700774379895	bayes_pls_golite062009
binding	2.4389817190572	bayes_pls_golite062009
substrate-specific transporter activity	2.26725422172281	bayes_pls_golite062009
protein transporter activity	1.76605071606564	bayes_pls_golite062009
protein binding	1.63705839411934	bayes_pls_golite062009
cation-transporting ATPase activity	1.60849969922683	bayes_pls_golite062009
transmembrane transporter activity	1.28481004323799	bayes_pls_golite062009
clathrin binding	0.53271167669517	bayes_pls_golite062009
hydrolase activity	0.528047226063932	bayes_pls_golite062009
active transmembrane transporter activity	0.252495966234234	bayes_pls_golite062009
primary active transmembrane transporter activity	0.226380819487924	bayes_pls_golite062009
nucleic acid binding	0.221901941018475	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.217517113570989	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	0.178770060806735	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	0.175241020572885	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	0.174922130116569	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.100181463251306	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions	0.0949889863173228	bayes_pls_golite062009
pyrophosphatase activity	0.0635404099346928	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.0548082069333885	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.052195223119721	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: