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View Structure Prediction Details

Protein: prp2
Organism: Schizosaccharomyces pombe
Length: 517 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for prp2.

Description E-value Query
Range
Subject
Range
gi|73976783 - gi|73976783|ref|XP_857420.1| PREDICTED: similar to Polyadenylate-binding protein 4 (Poly(A)-binding ...
221.0 [0..161] [514..56]
gi|76689281 - gi|76689281|ref|XP_881384.1| PREDICTED: similar to Polyadenylate-binding protein 4 (Poly(A)-binding ...
219.0 [0..161] [514..56]
gi|48734702 - gi|48734702|gb|AAH71591.1| PABPC4 protein [Homo sapiens]
218.0 [0..161] [514..56]
gi|55959639, gi|... - gi|66267552|gb|AAH94755.1| PABPC4 protein [Homo sapiens], gi|55962217|emb|CAI12298.1| poly(A) bindin...
gi|114555673 - gi|114555673|ref|XP_001170937.1| PREDICTED: poly A binding protein, cytoplasmic 4 isoform 1 [Pan tro...
217.0 [0..161] [514..56]

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Predicted Domain #1
Region A:
Residues: [1-111]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDLSSRLSSG SSRIPKRHRD YRDEEPRRER GSGGIGREDP RGHYGSERPR RRRRDESDFR  60
   61 RHRESRERSY REDERPRRER RYDDYEPRSL RYSSVGRSRS PPPSRERSVR S

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [112-192]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IEQELEQLRD VTPINQWKRK RSLWDIKPPG YELVTADQAK MSGVFPLPGA PRAAVTDPEK  60
   61 LLEFARSAEG SIIAPPPPLQ P

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [193-307]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GASRQARRLV VTGIPNEFVE DAFVSFIEDL FISTTYHKPE TKHFSSVNVC KEENFAILEV  60
   61 ATPEDATFLW GLQSESYSND VFLKFQRIQN YIVPQITPEV SQKRSDDYAK NDVLD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 29.522879
Match: 1fxlA
Description: Hu antigen D (Hud)
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [308-517]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKDKIYISNL PLNLGEDQVV ELLKPFGDLL SFQLIKNIAD GSSKGFCFCE FKNPSDAEVA  60
   61 ISGLDGKDTY GNKLHAQFAC VGLNQAMIDK SNGMAILTEL AKASSQSIPT RVLQLHNLIT 120
  121 GDEIMDVQEY EDIYESVKTQ FSNYGPLIDI KIPRSIGTRN SGLGTGKVFV RYSDIRSAEV 180
  181 AMEEMKGCKF NDRTIVIAFY GEDCYKANAW 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 29.154902
Match: 1cvjA
Description: Poly(A)-binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 6.73097473547076 bayes_pls_golite062009
6.62953239642182 bayes_pls_golite062009
mRNA binding 5.29759606920196 bayes_pls_golite062009
nucleic acid binding 4.92126426323641 bayes_pls_golite062009
snRNA binding 4.06596327298973 bayes_pls_golite062009
binding 3.64400841800969 bayes_pls_golite062009
poly-pyrimidine tract binding 3.11990160533699 bayes_pls_golite062009
U1 snRNA binding 3.02511982045347 bayes_pls_golite062009
single-stranded RNA binding 2.93798024346416 bayes_pls_golite062009
transcription regulator activity 1.92450390013691 bayes_pls_golite062009
DNA binding 1.8021593476478 bayes_pls_golite062009
structural molecule activity 1.29928829870122 bayes_pls_golite062009
transcription factor activity 1.15127506309683 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
mRNA 3'-UTR binding 0.591700155096213 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.425042944899091 bayes_pls_golite062009
transporter activity 0.417047632648771 bayes_pls_golite062009
sequence-specific DNA binding 0.383589644462932 bayes_pls_golite062009
cytoskeletal protein binding 0.288834004308736 bayes_pls_golite062009
transmembrane transporter activity 0.288804044686487 bayes_pls_golite062009
snoRNA binding 0.0568636182001701 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.00171911393626201 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle