YRC Public Data Repository - Protein Structure Prediction

Protein:	tub1
Organism:	Schizosaccharomyces pombe
Length:	449 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for tub1.

Description	E-value	Query Range	Subject Range
TBA1C_MOUSE - Tubulin alpha-1C chain OS=Mus musculus GN=Tuba1c PE=1 SV=1 gi\|124481732, gi... - gi\|148225011\|ref\|NP_001091315.1\| hypothetical protein LOC100037141 [Xenopus laevis], gi\|124481732\|gb... TBA1C_CRIGR - Tubulin alpha-1C chain OS=Cricetulus griseus GN=TUBA1C PE=2 SV=1	703.0	[0..1]	[449..1]
gi\|73996516 - gi\|73996516\|ref\|XP_850665.1\| PREDICTED: similar to Tubulin alpha-2 chain (Alpha-tubulin 2) isoform 2...	703.0	[0..1]	[449..1]
TBA1C_RAT - Tubulin alpha-1C chain OS=Rattus norvegicus GN=Tuba1c PE=1 SV=1	701.0	[0..1]	[449..1]
TBA_XENLA - Tubulin alpha chain OS=Xenopus laevis GN=tuba PE=2 SV=2	701.0	[0..1]	[449..1]
gi\|60653689 - gi\|60653689\|gb\|AAX29538.1\| tubulin alpha 6 [synthetic construct]	700.0	[0..1]	[449..1]
gi\|114644941 - gi\|114644941\|ref\|XP_001158840.1\| PREDICTED: tubulin alpha 6 isoform 1 [Pan troglodytes] gi\|123990474, gi... - gi\|123999316\|gb\|ABM87234.1\| tubulin, alpha 6 [synthetic construct], gi\|123990474\|gb\|ABM83912.1\| tubu... TUBA1C - tubulin, alpha 1c	700.0	[0..1]	[449..1]
gi\|67463741, gi\|... - gi\|67463743\|pdb\|1Z2B\|C Chain C, Tubulin-Colchicine-Vinblastine: Stathmin-Like Domain Complex, gi\|674...	700.0	[0..1]	[448..1]
gi\|28422169, gi\|... - gi\|28422169\|gb\|AAH46841.1\| Tuba6-prov protein [Xenopus laevis], gi\|147904718\|ref\|NP_001080789.1\| tub... gi\|38174018, gi\|... - gi\|89272843\|emb\|CAJ82111.1\| tubulin, alpha 6 [Xenopus tropicalis], gi\|45360809\|ref\|NP_989078.1\| tubu...	700.0	[0..1]	[449..1]

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Predicted Domain #1

Region A:
Residues: [1-449]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MREIISIHVG QAGTQIGNAC WELYCLEHGI QPNGYMNPET ASQNSDGGFS TFFSETGQGK  60
   61 YVPRSIYVDL EPNVIDQVRT GPYRDLFHPE QLITGKEDAS NNYARGHYTV GKELVDEVTD 120
  121 KIRRIADNCS GLQGFLVFHS FGGGTGSGFG ALLLERLAME YTKKSKLQFS VYPAPQVSTS 180
  181 VVEPYNSVLT THATLDLADC TFMVDNESCY DICRRNLDIE RPSYENLNRL IAQVVSSITA 240
  241 SLRFEGSLNV DLAEFQTNLV PYPRIHFPLV TYAPIVSAAK AFHESNSVQE ITNQCFEPYN 300
  301 QMVKCDPRAG RYMATCLLYR GDVIPRDVQA AVTTIKAKRT IQFVDWCPTG FKIGICDRPP 360
  361 QHIEGSEIAK VDRAVCMLSN TTSIAEAWSR LDHKFDLMYS KRAFVHWYVG EGMEEGEFSE 420
  421 AREDLAALER DYEEVGQDSM EVDYMEEEY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1z2bA
Description:	Tubulin-colchicine-vinblastine: stathmin-like domain complex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
structural constituent of cytoskeleton	4.04224160177678	bayes_pls_golite062009
structural molecule activity	3.32779015200848	bayes_pls_golite062009
tubulin binding	2.4432045213385	bayes_pls_golite062009
cytoskeletal protein binding	2.24606230377981	bayes_pls_golite062009
binding	2.00508289492248	bayes_pls_golite062009
GTPase activity	1.87512665946067	bayes_pls_golite062009
nucleoside-triphosphatase activity	1.77500173070686	bayes_pls_golite062009
pyrophosphatase activity	1.7017047947554	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	1.68267378160702	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	1.68038087466376	bayes_pls_golite062009
protein binding	1.60795853516357	bayes_pls_golite062009
MHC class I protein binding	1.46574865275013	bayes_pls_golite062009
gamma-tubulin binding	1.02742779831447	bayes_pls_golite062009
hydrolase activity	0.502038132260603	bayes_pls_golite062009
receptor binding	0.00945891657658993	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: