YRC Public Data Repository - Protein Structure Prediction

Protein:	rpn7
Organism:	Schizosaccharomyces pombe
Length:	409 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for rpn7.

Description	E-value	Query Range	Subject Range
gi\|114587651 - gi\|114587651\|ref\|XP_520898.2\| PREDICTED: proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 ...	305.0	[0..10]	[403..222]
gi\|12845617 - gi\|12845617\|dbj\|BAB26823.1\| unnamed protein product [Mus musculus]	295.0	[0..10]	[403..4]
gi\|149040032, gi... - gi\|38454206\|ref\|NP_942025.1\| proteasome, 26S, non-ATPase regulatory subunit 6 [Rattus norvegicus], g...	294.0	[0..10]	[403..4]
gi\|208965390 - gi\|208965390\|dbj\|BAG72709.1\| proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 [synthetic c... ENSPTRT00000028219 - null PSMD6 - proteasome (prosome, macropain) 26S subunit, non-ATPase, 6	294.0	[0..10]	[403..4]
PSMD6_BOVIN - 26S proteasome non-ATPase regulatory subunit 6 OS=Bos taurus GN=PSMD6 PE=2 SV=1	293.0	[0..10]	[403..4]
AGAP002061-PA - 26S proteasome regulatory subunit N7\|protein_coding\|2R:14716192:14717361:1\|gene:AGAP002061 gi\|58395080, gi\|... - gi\|58395080\|ref\|XP_320986.2\| AGAP002061-PA [Anopheles gambiae str. PEST], gi\|55233320\|gb\|EAA01099.3\|...	293.0	[0..10]	[403..4]
gi\|109037701 - gi\|109037701\|ref\|XP_001093028.1\| PREDICTED: proteasome (prosome, macropain) 26S subunit, non-ATPase,... gi\|90074922 - gi\|90074922\|dbj\|BAE87141.1\| unnamed protein product [Macaca fascicularis]	293.0	[0..10]	[403..4]
gi\|73985103 - gi\|73985103\|ref\|XP_541816.2\| PREDICTED: similar to 26S proteasome non-ATPase regulatory subunit 6 (2...	292.0	[0..10]	[403..4]
gi\|27694784, gi\|... - gi\|27694784\|gb\|AAH43825.1\| P44s10-prov protein [Xenopus laevis], gi\|147904380\|ref\|NP_001080462.1\| hy...	289.0	[0..10]	[403..4]

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Predicted Domain #1

Region A:
Residues: [1-69]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCSPSATLTH RTMTEKARTV SDLTISQAIF ELSSPFLENK SQKALDTLFS AIRDHDLAPL  60
   61 YKYLSENPK

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [70-299]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TSASIDFDSN FLNSMIKKNE EKLAEFDKAI EDAQELNGEH EILEAMKNKA DYYTNICDRE  60
   61 RGVQLCDETF ERATLTGMKI DVLFSKIRLA YVYADMRVVG QLLEKLKPLI EKGGDWERKN 120
  121 RLKAYQGIYL MSIRNFSGAA DLLLDCMSTF SSTELLPYYD VVRYAVISGA ISLDRVDVKT 180
  181 KIVDSPEVLA VLPQNESMSS LEACINSLYL CDYSGFFRTL ADVEVNHLKC

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	5.522879
Match:	2fo7A
Description:	Crystal structure of an 8 repeat consensus TPR superhelix (trigonal crystal form)
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [300-409]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DQFLVAHYRY YVREMRRRAY AQLLESYRAL SIDSMAASFG VSVDYIDRDL ASFIPDNKLN  60
   61 CVIDRVNGVV FTNRPDEKNR QYQEVVKQGD VLLNKLQKYQ ATVMRGAFKV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	11.69897
Match:	1ufmA
Description:	Solution structure of the PCI domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	3.50995556050336	bayes_pls_golite062009
nucleic acid binding	3.38144578566524	bayes_pls_golite062009
binding	3.33026160538031	bayes_pls_golite062009
DNA binding	3.30822066787723	bayes_pls_golite062009
transcription factor activity	2.60537570879007	bayes_pls_golite062009
hydrolase activity	2.30467124306022	bayes_pls_golite062009
sequence-specific DNA binding	1.32971938164691	bayes_pls_golite062009
transcription activator activity	1.08566311616647	bayes_pls_golite062009
transcription repressor activity	0.95491822926452	bayes_pls_golite062009
protein binding	0.653872239015235	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.505349137311395	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.42135864069093	bayes_pls_golite062009
ubiquitin-protein ligase activity	0.136726704233672	bayes_pls_golite062009
small conjugating protein ligase activity	0.118016217031359	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: