YRC Public Data Repository - Protein Structure Prediction

Protein:	pdb1
Organism:	Schizosaccharomyces pombe
Length:	366 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for pdb1.

Description	E-value	Query Range	Subject Range
gi\|115956715, gi... - gi\|115956715\|ref\|XP_001185430.1\| PREDICTED: similar to Pyruvate dehydrogenase (lipoamide) beta [Stro...	331.0	[0..8]	[364..6]
gi\|147904698, gi... - gi\|54261489\|gb\|AAH84292.1\| PdhE1beta-2 protein [Xenopus laevis], gi\|147904698\|ref\|NP_001081808.1\| py...	328.0	[0..32]	[364..27]
gi\|157758977 - gi\|157758977\|ref\|XP_001671832.1\| Hypothetical protein CBG21051 [Caenorhabditis briggsae AF16] gi\|187022895, gi... - gi\|39581172\|emb\|CAE73577.1\| Hypothetical protein CBG21051 [Caenorhabditis briggsae], gi\|187022895\|em...	325.0	[0..35]	[366..22]
ODPB1_ARATH - Pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial OS=Arabidopsis thaliana GN=PDH2 PE...	324.0	[0..10]	[365..8]
gi\|118367391 - gi\|118367391\|ref\|XP_001016910.1\| Transketolase, pyridine binding domain containing protein [Tetrahym... gi\|118367391, gi... - gi\|89298677\|gb\|EAR96665.1\| Transketolase, pyridine binding domain containing protein [Tetrahymena th...	324.0	[0..15]	[363..73]
gi\|3850999, gi\|1... - gi\|3850999\|gb\|AAC72192.1\| pyruvate dehydrogenase E1 beta subunit isoform 1 [Zea mays], gi\|223949679\|...	324.0	[0..30]	[365..31]
orf19.12753, orf... - PDB1 CGDID:CAL0003677 Assembly 19, Contig19-10225 (11999, 13138) CDS, translated using codon table 1... gi\|238881456 - gi\|238881456\|gb\|EEQ45094.1\| pyruvate dehydrogenase E1 component [Candida albicans WO-1] gi\|46438797, gi\|... - gi\|68477732\|ref\|XP_717018.1\| hypothetical protein CaO19.12753 [Candida albicans SC5314], gi\|68477571...	324.0	[0..36]	[364..50]
gi\|269959173\|ref... - pyruvate dehydrogenase subunit beta [Anaplasma centrale str. Israel] gi\|56388545, gi\|... - gi\|56417313\|ref\|YP_154387.1\| pyruvate dehydrogenase subunit beta [Anaplasma marginale str. St. Marie...	323.0	[0..33]	[366..9]
CE27647 - pyruvate dehydrogenase status:Confirmed UniProt:O44451 protein_id:AAB92024.2	323.0	[0..35]	[365..22]

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Predicted Domain #1

Region A:
Residues: [1-366]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIRLQKFGEI VGTSRSWKLL SSTIAKRYSS SSNGVKEMTV RDALNSAMEE EMKRDDRVFL  60
   61 IGEEVAQYNG AYKISRGLLD KFGPKRVIDT PITEMGFTGL ATGAAFAGLR PICEFMTFNF 120
  121 SMQAIDHIVN SAARTLYMSG GIQACPIVFR GPNGPAAAVA AQHSQHFAPW YGSIPGLKVV 180
  181 SPYSAEDARG LLKAAIRDPN PVVVLENEIL YGKTFPISKE ALSEDFVLPF GLAKVERPGK 240
  241 DITIVGESIS VVTALEAADK LKADYGVEAE VINLRSIRPL DINTIAASVK KTNRIVTVDQ 300
  301 AYSQHGIGSE IAAQIMESDA FDYLDAPVER VSMADVPMPY SHPVEAASVP NADVVVAAAK 360
  361 KCLYIK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	85.30103
Match:	1ni4B
Description:	E1-beta subunit of pyruvate dehydrogenase, Pyr module; E1-beta subunit of pyruvate dehydrogenase, C-domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
pyruvate dehydrogenase activity	11.3856674722026	bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity	11.0549577473177	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	10.8180381281695	bayes_pls_golite062009
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity	7.00951713446616	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	5.65146926050423	bayes_pls_golite062009
acetolactate synthase activity	4.51986503762195	bayes_pls_golite062009
alpha-ketoacid dehydrogenase activity	2.61614462349133	bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups	1.29819462996182	bayes_pls_golite062009
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer	0.667418924427388	bayes_pls_golite062009
binding	0.551586872853971	bayes_pls_golite062009
catalytic activity	0.545407789079971	bayes_pls_golite062009
oxidoreductase activity	0.281475773435032	bayes_pls_golite062009
pyruvate decarboxylase activity	0.198062360371269	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: