YRC Public Data Repository - Protein Structure Prediction

Protein:	pda1
Organism:	Schizosaccharomyces pombe
Length:	409 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for pda1.

Description	E-value	Query Range	Subject Range
gi\|207345769 - gi\|207345769\|gb\|EDZ72479.1\| YER178Wp-like protein [Saccharomyces cerevisiae AWRI1631] PDA1 - E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarbo...	333.0	[0..3]	[409..31]
gi\|49095676, gi\|... - gi\|67537984\|ref\|XP_662766.1\| hypothetical protein AN5162.2 [Aspergillus nidulans FGSC A4], ref\|XP_40...	330.0	[0..1]	[408..2]
gi\|39976937, gi\|... - gi\|39976937\|ref\|XP_369856.1\| conserved hypothetical protein [Magnaporthe grisea 70-15], gb\|EAA56400....	328.0	[0..4]	[408..7]
gi\|83770916 - gi\|83770916\|dbj\|BAE61049.1\| unnamed protein product [Aspergillus oryzae] gi\|169763976 - gi\|169763976\|ref\|XP_001727888.1\| hypothetical protein [Aspergillus oryzae RIB40]	327.0	[0..1]	[408..2]
gi\|114193839, gi... - gi\|115390821\|ref\|XP_001212915.1\| pyruvate dehydrogenase E1 component alpha subunit, mitochondrial pr...	325.0	[0..1]	[408..2]
gi\|119196145, gi... - gi\|90307462\|gb\|EAS37093.1\| pyruvate dehydrogenase E1 component alpha subunit, mitochondrial precurso...	323.0	[0..1]	[408..1]
gi\|85083464 - gi\|85083464\|ref\|XP_957122.1\| pyruvate dehydrogenase E1 component alpha subunit, mitochondrial [Neuro... gi\|28918208, gi\|... - gi\|32411713\|ref\|XP_326337.1\| hypothetical protein [Neurospora crassa], gi\|28918208\|gb\|EAA27886.1\| py...	322.0	[0..21]	[409..29]
gi\|45201199, gi\|... - gi\|45201199\|ref\|NP_986769.1\| AGR103Wp [Ashbya gossypii ATCC 10895], gi\|44986053\|gb\|AAS54593.1\| AGR10... gi\|44986053 - gi\|44986053\|gb\|AAS54593.1\| AGR103Wp [Ashbya gossypii ATCC 10895]	322.0	[0..11]	[408..2]

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Predicted Domain #1

Region A:
Residues: [1-409]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFRTCTKIGT VPKVLVNQKG LIDGLRRVTT DATTSRANPA HVPEEHDKPF PVKLDDSVFE  60
   61 GYKIDVPSTE IEVTKGELLG LYEKMVTIRR LELACDALYK AKKIRGFCHL SIGQEAVAAG 120
  121 IEGAITLDDS IITSYRCHGF AYTRGLSIRS IIGELMGRQC GASKGKGGSM HIFAKNFYGG 180
  181 NGIVGAQIPL GAGIGFAQKY LEKPTTTFAL YGDGASNQGQ AFEAFNMAKL WGLPVIFACE 240
  241 NNKYGMGTSA ERSSAMTEFY KRGQYIPGLL VNGMDVLAVL QASKFAKKYT VENSQPLLME 300
  301 FVTYRYGGHS MSDPGTTYRS REEVQKVRAA RDPIEGLKKH IMEWGVANAN ELKNIEKRIR 360
  361 GMVDEEVRIA EESPFPDPIE ESLFSDVYVA GTEPAYARGR NSLEYHQYK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	82.39794
Match:	1ni4A
Description:	E1-beta subunit of pyruvate dehydrogenase (PP module)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
pyruvate dehydrogenase activity	11.3856674722026	bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity	11.0549577473177	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	10.8180381281695	bayes_pls_golite062009
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity	7.00951713446616	bayes_pls_golite062009
alpha-ketoacid dehydrogenase activity	6.25236550086321	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	4.89064211833637	bayes_pls_golite062009
acetolactate synthase activity	4.51986503762195	bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups	3.8269109174531	bayes_pls_golite062009
2-oxoisovalerate dehydrogenase (acylating) activity	3.00128844859152	bayes_pls_golite062009
cyclin-dependent protein kinase 5 activator regulator activity	3.00128844859152	bayes_pls_golite062009
catalytic activity	2.25537597692103	bayes_pls_golite062009
oxidoreductase activity	1.85833680148029	bayes_pls_golite062009
transketolase activity	1.58421424158131	bayes_pls_golite062009
protein binding	0.992849906276347	bayes_pls_golite062009
binding	0.750068469698571	bayes_pls_golite062009
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer	0.667418924427388	bayes_pls_golite062009
pyruvate decarboxylase activity	0.198062360371269	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: