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Protein Overview: PDA1

General Information:
Name(s) found: PDA1 / YER178W [SGD]
Description(s) found:
Found 8 descriptions.
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  • E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 443 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial pyruvate dehydrogenase complex [TASLink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed articleLink to PubMed article]
    mitochondrial nucleoid [IDALink to PubMed article]
    Biological Process: pyruvate metabolic process [NASLink to PubMed article]
    Molecular Function: pyruvate dehydrogenase (acetyl-transferring) activity [IMPLink to PubMed article][TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFVAPVSSQK LDTAIRKETT FVPMLAASFK RQPSQLVRGL GAVLRTPTRI GHVRTMATLK  60
   61 TTDKKAPEDI EGSDTVQIEL PESSFESYML EPPDLSYETS KATLLQMYKD MVIIRRMEMA 120
  121 CDALYKAKKI RGFCHLSVGQ EAIAVGIENA ITKLDSIITS YRCHGFTFMR GASVKAVLAE 180
  181 LMGRRAGVSY GKGGSMHLYA PGFYGGNGIV GAQVPLGAGL AFAHQYKNED ACSFTLYGDG 240
  241 ASNQGQVFES FNMAKLWNLP VVFCCENNKY GMGTAASRSS AMTEYFKRGQ YIPGLKVNGM 300
  301 DILAVYQASK FAKDWCLSGK GPLVLEYETY RYGGHSMSDP GTTYRTRDEI QHMRSKNDPI 360
  361 AGLKMHLIDL GIATEAEVKA YDKSARKYVD EQVELADAAP PPEAKLSILF EDVYVKGTET 420
  421 PTLRGRIPED TWDFKKQGFA SRD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run SEC10 No Comments De Craene, J., et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..443] PSI-BLAST 407.154902 Branched-chain alpha-keto acid dehydrogenase, PP module


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle