YRC Public Data Repository - Protein Structure Prediction

Protein:	PDA1
Organism:	Saccharomyces cerevisiae
Length:	443 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PDA1.

Description	E-value	Query Range	Subject Range
PDA1 - E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarbo... gi\|151944896 - gi\|151944896\|gb\|EDN63155.1\| pyruvate dehydrogenase alpha subunit (E1 alpha) [Saccharomyces cerevisia... ODPA_YEAST - Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial OS=Saccharomyces cerevisiae (strain... gi\|190405734 - gi\|190405734\|gb\|EDV09001.1\| pyruvate dehydrogenase alpha subunit [Saccharomyces cerevisiae RM11-1a]	0.0	[24..443]	[1..420]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[50..438]	[8..388]
ODPA_MOUSE - Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial OS=Mus musculus GN=Pd...	0.0	[50..438]	[8..388]
ODPA_KLULA - Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial OS=Kluyveromyces lactis GN=PDA1 PE=... ODPA_KLULA - Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial OS=Kluyveromyces lactis (strain ATC...	0.0	[27..443]	[2..408]
ODPA_RAT - (P26284) Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial precursor (E...	0.0	[50..438]	[8..388]
PDHA2 - pyruvate dehydrogenase (lipoamide) alpha 2	0.0	[49..438]	[5..386]
ODPA_SMIMA - Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial (Fragment) OS=Sminthopsis macroura ...	0.0	[71..438]	[2..361]
gi\|2623175 - gi\|2623175\|gb\|AAB86816.1\| pyruvate dehydrogenase E1 component alpha subunit [Pichia stipitis]	0.0	[49..442]	[3..394]

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Predicted Domain #1

Region A:
Residues: [1-443]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFVAPVSSQK LDTAIRKETT FVPMLAASFK RQPSQLVRGL GAVLRTPTRI GHVRTMATLK  60
   61 TTDKKAPEDI EGSDTVQIEL PESSFESYML EPPDLSYETS KATLLQMYKD MVIIRRMEMA 120
  121 CDALYKAKKI RGFCHLSVGQ EAIAVGIENA ITKLDSIITS YRCHGFTFMR GASVKAVLAE 180
  181 LMGRRAGVSY GKGGSMHLYA PGFYGGNGIV GAQVPLGAGL AFAHQYKNED ACSFTLYGDG 240
  241 ASNQGQVFES FNMAKLWNLP VVFCCENNKY GMGTAASRSS AMTEYFKRGQ YIPGLKVNGM 300
  301 DILAVYQASK FAKDWCLSGK GPLVLEYETY RYGGHSMSDP GTTYRTRDEI QHMRSKNDPI 360
  361 AGLKMHLIDL GIATEAEVKA YDKSARKYVD EQVELADAAP PPEAKLSILF EDVYVKGTET 420
  421 PTLRGRIPED TWDFKKQGFA SRD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	407.154902
Match:	1dtwA_
Description:	Branched-chain alpha-keto acid dehydrogenase, PP module
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits