YRC Public Data Repository - Protein Structure Prediction

Protein:	hsp60
Organism:	Schizosaccharomyces pombe
Length:	582 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for hsp60.

Description	E-value	Query Range	Subject Range
gi\|76648520 - gi\|76648520\|ref\|XP_589340.2\| PREDICTED: similar to 60 kDa heat shock protein, mitochondrial precurso...	642.0	[0..3]	[566..172]
CH603_SINMW - 60 kDa chaperonin 3 OS=Sinorhizobium medicae (strain WSM419) GN=groL3 PE=3 SV=1	629.0	[0..33]	[574..2]
CH602_CHESB - 60 kDa chaperonin 2 OS=Chelativorans sp. (strain BNC1) GN=groL2 PE=3 SV=1	628.0	[0..33]	[574..2]
gi\|109506917 - gi\|109506917\|ref\|XP_001071820.1\| PREDICTED: similar to 60 kDa heat shock protein, mitochondrial prec...	626.0	[0..1]	[566..81]
CH601_RHISN - 60 kDa chaperonin 1 OS=Rhizobium sp. (strain NGR234) GN=groL1 PE=3 SV=1	625.0	[0..33]	[574..2]
CH602_RHILO - 60 kDa chaperonin 2 OS=Rhizobium loti (strain MAFF303099) GN=groL2 PE=3 SV=1 CH62_RHILO, CH60... - (Q98IH9) 60 kDa chaperonin 2 (Protein Cpn60 2) (groEL protein 2), 60 kDa chaperonin 2 OS=Rhizobium l...	624.0	[0..33]	[579..2]
CH604_RHIEC - 60 kDa chaperonin 4 OS=Rhizobium etli (strain CFN 42 / ATCC 51251) GN=groL4 PE=3 SV=1	624.0	[0..33]	[574..2]
CH601_NITWN - 60 kDa chaperonin 1 OS=Nitrobacter winogradskyi (strain Nb-255 / ATCC 25391) GN=groL1 PE=3 SV=1	623.0	[0..33]	[574..2]
CH60_METFK - 60 kDa chaperonin OS=Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875) GN=groL PE=3 SV...	622.0	[0..33]	[581..2]
CH65_RHIME, CH60... - (P35471) 60 kDa chaperonin 5 (Protein Cpn60 5) (groEL protein 5), 60 kDa chaperonin 5 OS=Rhizobium m... CH605_RHIME - 60 kDa chaperonin 5 OS=Rhizobium meliloti (strain 1021) GN=groL5 PE=2 SV=2	622.0	[0..33]	[574..2]

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Predicted Domain #1

Region A:
Residues: [1-582]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVSFLSSSVS RLPLRIAGRR IPGRFAVPQV RTYAKDLKFG VDARASLLTG VDTLARAVSV  60
   61 TLGPKGRNVL IDQPFGSPKI TKDGVTVARS VSLKDKFENL GARLVQDVAS KTNEVAGDGT 120
  121 TTATVLTRAI FSETVRNVAA GCNPMDLRRG IQLAVDNVVE FLQANKRDIT TSEEISQVAT 180
  181 ISANGDTHIG ELLAKAMERV GKEGVITVKE GRTISDELEV TEGMKFDRGY ISPYFITDVK 240
  241 SQKVEFENPL ILLSEKKVSA VQDILPSLEL AAQQRRPLVI IAEDVDGEAL AACILNKLRG 300
  301 QLQVVAIKAP GFGDNRRNML GDLAVLTDSA VFNDEIDVSI EKAQPHHLGS CGSVTVTKED 360
  361 TIIMKGAGDH VKVNDRCEQI RGVMADPNLT EYEKEKLQER LAKLSGGIAV IKVGGSSEVE 420
  421 VNEKKDRIVD ALNAVKAAVS EGVLPGAGTS FVKASLRLGD IPTNNFDQKL GVEIVRKAIT 480
  481 RPAQTILENA GLEGNLIVGK LKELYGKEFN IGYDIAKDRF VDLNEIGVLD PLKVVRTGLV 540
  541 DASGVASLMG TTECAIVDAP EESKAPAGPP GMGGMGGMPG MM

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	172.0
Match:	1iokA
Description:	GroEL, E domain; GroEL, A domain; GroEL, I domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
unfolded protein binding	7.60116801069598	bayes_pls_golite062009
misfolded protein binding	2.60932901317399	bayes_pls_golite062009
lipopolysaccharide binding	2.08823822762317	bayes_pls_golite062009
binding	2.07154556649829	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	1.90846357786961	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	1.85422470116133	bayes_pls_golite062009
protein binding	1.68543685258552	bayes_pls_golite062009
nucleic acid binding	1.67284737458957	bayes_pls_golite062009
DNA binding	1.53776996197958	bayes_pls_golite062009
transporter activity	1.27879339110564	bayes_pls_golite062009
transmembrane transporter activity	1.08697283907212	bayes_pls_golite062009
chaperone binding	0.91200031047441	bayes_pls_golite062009
substrate-specific transporter activity	0.828920415160435	bayes_pls_golite062009
ATPase activity, coupled	0.787685249362834	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.75018875403424	bayes_pls_golite062009
pyrophosphatase activity	0.69634667457441	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.682843768728088	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.680378643689288	bayes_pls_golite062009
structure-specific DNA binding	0.650832159017275	bayes_pls_golite062009
ATPase activity	0.584574936611857	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.573106450426516	bayes_pls_golite062009
insulin binding	0.54263404774246	bayes_pls_golite062009
single-stranded DNA binding	0.44104272460881	bayes_pls_golite062009
catalytic activity	0.424959044318554	bayes_pls_golite062009
cell surface binding	0.326492680678891	bayes_pls_golite062009
peptide hormone binding	0.280457039468896	bayes_pls_golite062009
ion transmembrane transporter activity	0.280310103153739	bayes_pls_golite062009
active transmembrane transporter activity	0.275534581026027	bayes_pls_golite062009
primary active transmembrane transporter activity	0.252704226951294	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.243984617084631	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	0.205808843369749	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	0.202279803135899	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	0.20198255686005	bayes_pls_golite062009
cation transmembrane transporter activity	0.0778814959589007	bayes_pls_golite062009
hydrolase activity	0.0491351110520448	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: