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View Structure Prediction Details

Protein: dfr1
Organism: Schizosaccharomyces pombe
Length: 461 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for dfr1.

Description E-value Query
Range
Subject
Range
gi|404819, gi|11... - gi|404819|gb|AAA57051.1| dihydropteridine reductase, pir||T43248 dihydrofolate reductase (EC 1.5.1.3...
402.0 [0..1] [461..1]
DYR_RAT - Dihydrofolate reductase OS=Rattus norvegicus GN=Dhfr PE=2 SV=3
199.0 [0..231] [449..1]
gi|37654603 - gi|37654603|gb|AAQ96635.1| ubiquitin-ts degron; DHFR [Degron tagging vector pSMRG2+]
gi|37654599 - gi|37654599|gb|AAQ96632.1| ubiquitin-ts degron; DHFR [Degron tagging vector pSMUG2+]
199.0 [0..219] [449..71]
DYR_PIG - Dihydrofolate reductase OS=Sus scrofa GN=DHFR PE=1 SV=1
gi|66093 - pir||RDPGD dihydrofolate reductase (EC 1.5.1.3) - pig
198.0 [0..232] [449..1]
gi|73984093 - gi|73984093|ref|XP_851329.1| PREDICTED: similar to Dihydrofolate reductase [Canis familiaris]
198.0 [0..233] [449..7]
gi|85658490, gi|... - gi|88601320|tpd|FAA00073.1| TPA: dihydrofolate reductase [Cricetulus griseus], gi|85658490|dbj|BAE78...
gi|304502 - gi|304502|gb|AAA36970.1| dihydrofolate reductase (EC 1.5.1.3)
197.0 [0..231] [448..1]
DYR_MOUSE - Dihydrofolate reductase OS=Mus musculus GN=Dhfr PE=1 SV=3
197.0 [0..231] [449..1]
gi|51243225 - gi|51243225|gb|AAT99412.1| dihydrofolate reductase [Pneumocystis jirovecii]
197.0 [0..232] [448..4]

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Predicted Domain #1
Region A:
Residues: [1-228]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKPLKVLCL HGWIQSGPVF SKKMGSVQKY LSKYAELHFP TGPVVADEEA DPNDEEEKKR  60
   61 LAALGGEQNG GKFGWFEVED FKNTYGSWDE SLECINQYMQ EKGPFDGLIG FSQGAGIGAM 120
  121 LAQMLQPGQP PNPYVQHPPF KFVVFVGGFR AEKPEFDHFY NPKLTTPSLH IAGTSDTLVP 180
  181 LARSKQLVER CENAHVLLHP GQHIVPQQAV YKTGIRDFMF SAPTKEPT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.0
Match: 1fj2A
Description: Acyl protein thioesterase 1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
catalytic activity 1.39629727416851 bayes_pls_golite062009
binding 0.978846093152455 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.736960094719075 bayes_pls_golite062009
acetylcholine binding 0.613144231901347 bayes_pls_golite062009
structural molecule activity 0.351605985650605 bayes_pls_golite062009
carboxylesterase activity 0.0264147222103929 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [229-461]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KHPRDLTMIV AVSSPNLGIG KKNSMPWHIK QEMAYFANVT SSTESSGQLE EGKSKIMNVV  60
   61 IMGRSCYDSL PKKNRPLKDR INIVITRNSN YNFGLTKKEK MPENLYAADC IDSALDLVAE 120
  121 KYGADSDIQV GKVFIIGGSF LYGSALYHPL TKNLLFTRIH KEYPCDSFFP FEPAESSDWV 180
  181 RKAHPELEKF VGIPVEEGRL KAASSNKEEV EIEFELYGKN DDVNVALEKL SIC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 49.154902
Match: 1cd2A
Description: Dihydrofolate reductases, eukaryotic type
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
dihydrofolic acid binding 5.17709559620199 bayes_pls_golite062009
dihydrofolate reductase activity 4.66343252900911 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 4.14137539326183 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH group of donors 3.88025481634404 bayes_pls_golite062009
binding 1.80954375334006 bayes_pls_golite062009
catalytic activity 1.48020895637259 bayes_pls_golite062009
oxidoreductase activity 0.63757996555211 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle