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Protein Overview: dfr1

General Information:
Name(s) found: dfr1 / SPCC1223.08c [Sanger Pombe]
Description(s) found:
Found 17 descriptions.
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  • dihydrofolate reductase Dfr1 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 461 amino acids

    Gene Ontology:
    Cellular Component: cytosol [IDALink to PubMed article][ISSLink to PubMed article]
    Biological Process: nucleotide biosynthetic process [ISSLink to PubMed article]
    folic acid and derivative metabolic process [ISSLink to PubMed article]
    glycine biosynthetic process [ISSLink to PubMed article]
    one-carbon metabolic process [IEA]
    Molecular Function: ATP binding [IEA]
    NADP or NADPH binding [IEA]
    dihydrofolate reductase activity [IGILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKPLKVLCL HGWIQSGPVF SKKMGSVQKY LSKYAELHFP TGPVVADEEA DPNDEEEKKR  60
   61 LAALGGEQNG GKFGWFEVED FKNTYGSWDE SLECINQYMQ EKGPFDGLIG FSQGAGIGAM 120
  121 LAQMLQPGQP PNPYVQHPPF KFVVFVGGFR AEKPEFDHFY NPKLTTPSLH IAGTSDTLVP 180
  181 LARSKQLVER CENAHVLLHP GQHIVPQQAV YKTGIRDFMF SAPTKEPTKH PRDLTMIVAV 240
  241 SSPNLGIGKK NSMPWHIKQE MAYFANVTSS TESSGQLEEG KSKIMNVVIM GRSCYDSLPK 300
  301 KNRPLKDRIN IVITRNSNYN FGLTKKEKMP ENLYAADCID SALDLVAEKY GADSDIQVGK 360
  361 VFIIGGSFLY GSALYHPLTK NLLFTRIHKE YPCDSFFPFE PAESSDWVRK AHPELEKFVG 420
  421 IPVEEGRLKA ASSNKEEVEI EFELYGKNDD VNVALEKLSI C

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..228] PSI-BLAST 35.0 Acyl protein thioesterase 1
    2 View Details [229..461] PSI-BLAST 49.154902 Dihydrofolate reductases, eukaryotic type

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • catalytic activity
    		•  1.39629727416851 bayes_pls_golite062009
  • binding
    		•  0.978846093152455 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  0.736960094719075 bayes_pls_golite062009
  • acetylcholine binding
    		•  0.613144231901347 bayes_pls_golite062009
  • structural molecule activity
    		•  0.351605985650605 bayes_pls_golite062009
  • carboxylesterase activity
    		•  0.0264147222103929 bayes_pls_golite062009
    2
    Term Confidence Notes
  • dihydrofolic acid binding
    		•  5.17709559620199 bayes_pls_golite062009
  • dihydrofolate reductase activity
    		•  4.66343252900911 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
    		•  4.14137539326183 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH group of donors
    		•  3.88025481634404 bayes_pls_golite062009
  • binding
    		•  1.80954375334006 bayes_pls_golite062009
  • catalytic activity
    		•  1.48020895637259 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.63757996555211 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle