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Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP. Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: dihydrofolate reductase activity
Acc: GO:0004146
Aspect: Molecular Function
Desc: Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+.
Synonyms:
  • NADPH-dihydrofolate reductase activity
  • folic acid reductase activity
  • 7,8-dihydrofolate reductase activity
  • pteridine reductase:dihydrofolate reductase activity
  • 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase activity
  • dihydrofolic acid reductase activity
  • DHFR
  • dihydrofolic reductase activity
  • tetrahydrofolate dehydrogenase activity
  • dihydrofolate reductase:thymidylate synthase activity
  • thymidylate synthetase-dihydrofolate reductase activity
  • dihydrofolate reduction
  • folic reductase activity
Proteins in PDR annotated with:
   This term: 22 [Search]
   Term or descendants: 22 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004146 - dihydrofolate reductase activity (interactive image map)
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Created and Maintained by: Michael Riffle