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View Structure Prediction Details

Protein: gi|24643130, gi|...
Organism: Drosophila melanogaster
Length: 722 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|24643130, gi|....

Description E-value Query
Range
Subject
Range
gi|54642685, gi|... - gi|54642685|gb|EAL31430.1| GA20097-PA [Drosophila pseudoobscura], gi|125980708|ref|XP_001354377.1| G...
639.0 [0..1] [722..1]

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Predicted Domain #1
Region A:
Residues: [1-207]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEPPGGVPPD RDRQLVLRNQ SAALVPVVVS APATGPGATT PNPQSSAQAQ LSLVPSKPTS  60
   61 LSLQPHAVLQ AMQQLSPSAG GNNNASSTAA TATSSSSGNA NSGSSPALAS TATAISATTQ 120
  121 AATAFSGSSV GHHHLQHHHQ HTHPHAPQQS QSQQPQPQHQ LQQPHPAGAP SSATQSHHHG 180
  181 SISVSGSGGG LLGSSGGSGN QQQAIEK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.045757
Match: 1y0fB
Description: No description for 1y0fB was found.

Predicted Domain #2
Region A:
Residues: [208-285]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSRPMAFDKM EMLVREMQDQ EHGVPVRQQK MFLTSIPYAF MGYDLIEWLM DRLQIEESEA  60
   61 LNIANQLCLH GYFFPVND

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.39794
Match: 1fshA
Description: Segment polarity protein Dishevelled-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.77201910025409 bayes_pls_golite062009
binding 3.52874320222492 bayes_pls_golite062009
DNA binding 3.44642410378325 bayes_pls_golite062009
nucleic acid binding 3.25777282180864 bayes_pls_golite062009
transcription factor activity 2.83460075788873 bayes_pls_golite062009
sequence-specific DNA binding 2.44917636781125 bayes_pls_golite062009
transcription repressor activity 2.39237599101586 bayes_pls_golite062009
transcription activator activity 2.35901958718112 bayes_pls_golite062009
protein binding 1.80415286835431 bayes_pls_golite062009
signal transducer activity 0.968719315363638 bayes_pls_golite062009
molecular transducer activity 0.968719315363638 bayes_pls_golite062009
transcription factor binding 0.63938506997853 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.49916895549368 bayes_pls_golite062009
specific transcriptional repressor activity 0.0565989703351002 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [286-401]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKTLTVKDDS SLYRFQTPYY WPWQHKAPDN VEYAIYLAKR SLRNKQRHAL EDYEAEALAS  60
   61 LHKNLKGKWD FISMQAEEQV RLAKERKKGD KIVGDSQERA YWRVHRPPPG QFTPLE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [402-487]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PCPVPSRDRQ GLKPNKKKTV DDMQRDVDYL GKSLNRTRMK MSQACESLVC YSETFSEYDF  60
   61 FLQPALPSNP WVTEDIAFWQ LNNTFV

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.83
Match: 1xhmB
Description: The Crystal Structure of a Biologically Active Peptide (SIGK) Bound to a G Protein Beta:Gamma Heterodimer
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.90500749049821 bayes_pls_golite062009
signal transducer activity 1.70315911322844 bayes_pls_golite062009
molecular transducer activity 1.70315911322844 bayes_pls_golite062009
protein binding 1.45781726933079 bayes_pls_golite062009
GTPase activity 0.944482131496004 bayes_pls_golite062009
receptor binding 0.0863620288738141 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [488-634]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DIPTEKRVKR WAISIEELVS DPTGLQEFTG FLEKEYSHEN IRFWIAVNRL RRSAHSQVAR  60
   61 KVNEIYEEFL KPGAPCEINI DGKTMESVLK GLKNPSRFTF DSASEHIYML LLKKDCYPRF 120
  121 IRSEHYKRLL DTGIQPSYKK RFFNFGG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 55.69897
Match: 1fqiA
Description: RGS9, RGS domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 2.39849429252906 bayes_pls_golite062009
binding 2.35238988967981 bayes_pls_golite062009
GTPase regulator activity 1.92987277493861 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 1.90800479999702 bayes_pls_golite062009
GTPase activator activity 1.87534424848905 bayes_pls_golite062009
enzyme activator activity 1.62073651679221 bayes_pls_golite062009
enzyme regulator activity 1.49796137854909 bayes_pls_golite062009
signal transducer activity 1.14361809679544 bayes_pls_golite062009
molecular transducer activity 1.14361809679544 bayes_pls_golite062009
beta-catenin binding 0.41692824983039 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [635-722]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VSGAKKKMTA ALSSQPNLGD AAKGPSGTSA GSSMMQAPPP GNLARRRGSD RSLTGSAHEL  60
   61 AVIGVNKDAG SKVPHSHSQS NLSEIPFR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle