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View Structure Prediction Details

Protein: Xpac-PA
Organism: Drosophila melanogaster
Length: 296 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Xpac-PA.

Description E-value Query
Range
Subject
Range
gi|1255595 - gi|1255595|dbj|BAA06690.1| Dxpa protein [Drosophila melanogaster]
358.0 [0..1] [296..1]
gi|60654147 - gi|60654147|gb|AAX29766.1| xeroderma pigmentosum complementation group A [synthetic construct]
309.0 [0..1] [296..1]
gi|61357324, gi|... - gi|61357324|gb|AAX41371.1| xeroderma pigmentosum complementation group A [synthetic construct], gi|1...
XPA - xeroderma pigmentosum, complementation group A
309.0 [0..1] [296..1]
gi|84579859, gi|... - gi|84579859|ref|NP_001033770.1| xeroderma pigmentosum, complementation group A [Bos taurus], gi|8375...
308.0 [0..1] [296..1]

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Predicted Domain #1
Region A:
Residues: [1-71]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAEVSTNES APPAEKKSKL TNAQKARIER NQAKAQKLRE AKLVSHPFKE LASNKEGGTH  60
   61 PEAALSQGSS V

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [72-296]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IKVQGTKYID SGGGFLLEQP VMPTGVGPAG LNKSGEEAPP ILDDAIAIPV QYEECLECGD  60
   61 MFADSYLFNN FGHSVCDKCR DKDERYALIT RTEAKAEYLL KDCDFDKREP KLRYISRKNP 120
  121 HNVRWGEMKL YLHLQIHQRA LEVWGSEEEL VRQHEAREDK REEGKARKYN KKMKQLRMEV 180
  181 RSSIYTKKTH EVHEHEFGPD TYDEEEDTYT HTCITCPYSE TYEKM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 43.69897
Match: 1xpaA
Description: SOLUTION STRUCTURE OF THE DNA-AND RPA-BINDING DOMAIN OF THE HUMAN REPAIR FACTOR XPA, NMR, 1 STRUCTURE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.96409924710655 bayes_pls_golite062009
protein binding 2.44501340584871 bayes_pls_golite062009
transcription regulator activity 2.22839475692516 bayes_pls_golite062009
DNA binding 2.18702281581791 bayes_pls_golite062009
nucleic acid binding 2.04270847321412 bayes_pls_golite062009
transcription activator activity 1.60639114794515 bayes_pls_golite062009
sequence-specific DNA binding 1.59705128803795 bayes_pls_golite062009
transcription factor activity 1.44182975349714 bayes_pls_golite062009
structure-specific DNA binding 0.610805977602876 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 0.55799224325565 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.51536225088963 bayes_pls_golite062009
transcription factor binding 0.43597775400036 bayes_pls_golite062009
transcription coactivator activity 0.42962641193703 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.37925266318051 bayes_pls_golite062009
double-stranded DNA binding 0.280685154942276 bayes_pls_golite062009
receptor activity 0.230063209127305 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.10722537662857 bayes_pls_golite062009
catalytic activity 0.101795606736461 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle