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View Structure Prediction Details

Protein: CG42666-PB
Organism: Drosophila melanogaster
Length: 787 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CG42666-PB.

Description E-value Query
Range		 Subject
Range
CG42666-PF, CG42... - This gene is referred to in FlyBase by the symbol Dmel\CG42666 (CG42666, FBgn0261548).The gene has a...
 471.0 [0..47] [787..21]

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Predicted Domain #1
Region A:
Residues: [1-393] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEQITNYFEH MDYVSFSVVA LPCVVIAVYG FLQVASGLAK CKNDKMQSCN KNSSSRITTT  60
   61 NNNVTTTSNI SGNSSNKRCP QKYTGNTLAV NSNMLAYQQQ ATAGGKNSTR KSRHNNNKQN 120
  121 HQQQQQQQQQ QFDHIHKRNG TAGGTGSECS PAAPTSNWLQ RGYGRQFVHS SCIEDKLLGH 180
  181 HNPGHRNSTS SDATSEDIDS SSELPNKSKG NSCAGSIHAS GGSKSRSKRH QKQSGQQTRN 240
  241 PDHNGQRTGA ATPCTGQKAK QGNAKWRQQQ PNPSSNNQQQ QMQQQMQQQK RGRNKKPGKW 300
  301 SNNIIDNPNS NHGGSSQQKT CDSSSSSALS SPTSSATTSA TSSPTNSPTS YPRANGNRKR 360
  361 IEAALEWRRE QELGRQNANF LVPPLRQYEQ LEF

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.07
Match: 1h1kI
Description: THE BLUETONGUE VIRUS (BTV) CORE BINDS DSRNA
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [394-508] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DDKTVVQQLR RHIIDNHLLR VYGFPVDSVV HEGAIEIFKC MPHMSFAAAL AETAQAVTVI  60
   61 NYHDGLTNRA EEEVANSTDS GNSSPQSLDS ESGGEWSGSE CESSNSSSSS AGEAA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [509-612] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LGLELKYCHF VPVERSLSKP CARCKRHFLV DELTGQYLTH EECQYHSGKY QRYYDGVSHG  60
   61 RWTCCNEGEE SSPGCCLGDR HVWSGSVVGV NGPYYDFVRT EHRG

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.01
Match: 2jm1A
Description: No description for 2jm1A was found.

Predicted Domain #4
Region A:
Residues: [613-787] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGEDEPAVYA LDCEMSYTGR GLDVTKVSLV ALNGQLVYEH FVRPVCDIID YNTQYSGITE  60
   61 TDLCSGAKSL AEVQRDLLQL ITADTILIGH GLENDLRALR LVHNTLIDTS ISFPHCNGFP 120
  121 YRRALRHLTK VHLKRDIQAG DGTTGHSSFE DSRACMELML WRVNRELDPA WSWDD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 48.0
Match: 1wljA
Description: human ISG20
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ribonuclease activity 5.30591758406946 bayes_pls_golite062009
exoribonuclease activity 3.71639182685131 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 3.59362615133405 bayes_pls_golite062009
3'-5'-exoribonuclease activity 3.1992647486402 bayes_pls_golite062009
exonuclease activity 3.13676176369406 bayes_pls_golite062009
nuclease activity 3.11657409772275 bayes_pls_golite062009
ribonuclease H activity 2.91966688044755 bayes_pls_golite062009
single-stranded DNA specific 3'-5' exodeoxyribonuclease activity 2.75003136922541 bayes_pls_golite062009
endonuclease activity 2.63074055051349 bayes_pls_golite062009
endoribonuclease activity 2.59247838057313 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 2.57498413015114 bayes_pls_golite062009
hydrolase activity 2.41899414621161 bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 2.04408785855894 bayes_pls_golite062009
3'-5' exonuclease activity 1.44123900197846 bayes_pls_golite062009
catalytic activity 1.25233849524628 bayes_pls_golite062009
nucleic acid binding 1.23371034593624 bayes_pls_golite062009
protein binding 1.16870279238939 bayes_pls_golite062009
deoxyribonuclease activity 1.1219517187744 bayes_pls_golite062009
transcription regulator activity 1.10433412699603 bayes_pls_golite062009
DNA binding 0.860359347662869 bayes_pls_golite062009
binding 0.762139256580538 bayes_pls_golite062009
DNA polymerase activity 0.717600245625866 bayes_pls_golite062009
endoribonuclease activity, producing 5'-phosphomonoesters 0.708753843279937 bayes_pls_golite062009
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 0.598360955770972 bayes_pls_golite062009
DNA-directed DNA polymerase activity 0.568273228950698 bayes_pls_golite062009
0.49473250705373 bayes_pls_golite062009
transcription factor activity 0.332903382446869 bayes_pls_golite062009
exodeoxyribonuclease activity 0.278838342302102 bayes_pls_golite062009
exodeoxyribonuclease activity, producing 5'-phosphomonoesters 0.261428436029202 bayes_pls_golite062009
structure-specific DNA binding 0.0701825322473915 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.00214157813118243 bayes_pls_golite062009
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