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View Structure Prediction Details

Protein: pan-PD, pan-PA, ...
Organism: Drosophila melanogaster
Length: 751 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for pan-PD, pan-PA, ....

Description E-value Query
Range
Subject
Range
pan-PH - The gene pangolin is referred to in FlyBase by the symbol Dmel\pan (CG34403, FBgn0085432). It is a p...
304.0 [0..1] [751..1]

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Predicted Domain #1
Region A:
Residues: [1-172]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPHTHSRHGS SGDDLCSTDE VKIFKDEGDR EDEKISSENL LVEEKSSLID LTESEEKGHK  60
   61 ISRPDHSPVF NKLDTHAPSF NMGYLVSPYS YANGSPSGLP VTMANKIGLP PFFCHNADPL 120
  121 STPPPAHCGI PPYQLDPKMG LTRPALYPFA GGQYPYPMLS SDMSQVASWH TP

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 76.130768
Match: PF08347.2
Description: No description for PF08347.2 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [173-258]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVYSASSFRT PYPSSLPINT TLASDFPFRF SPSLLPSVHA TSHHVINAHS AIVGVSSKQE  60
   61 CGVQDPTTNN RYPRNLEAKH TSNAQS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [259-370]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NESKETTNDK KKPHIKKPLN AFMLYMKEMR AKVVAECTLK ESAAINQILG RRWHELSREE  60
   61 QSKYYEKARQ ERQLHMELYP GWSARDNYGY VSKKKKRKKD RSTTDSGGNN MK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.69897
Match: 2lefA
Description: Lymphoid enhancer-binding factor, LEF1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA binding 5.15324651287773 bayes_pls_golite062009
nucleic acid binding 5.01228762819617 bayes_pls_golite062009
transcription regulator activity 4.9607192917135 bayes_pls_golite062009
sequence-specific DNA binding 4.06355503548774 bayes_pls_golite062009
transcription factor activity 3.82658263870186 bayes_pls_golite062009
binding 3.6211482127468 bayes_pls_golite062009
transcription repressor activity 3.17018042329608 bayes_pls_golite062009
transcription activator activity 2.95665802871704 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.75319687398598 bayes_pls_golite062009
protein binding 2.18211240370246 bayes_pls_golite062009
beta-catenin binding 2.16058631208641 bayes_pls_golite062009
chromatin binding 1.64428658020027 bayes_pls_golite062009
transcription factor binding 1.10315330167937 bayes_pls_golite062009
DNA bending activity 0.87985209274756 bayes_pls_golite062009
specific transcriptional repressor activity 0.4255419067266 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.261169200304829 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [371-523]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KCRARFGLDQ QSQWCKPCRR KKKCIRYMEA LNGNGPAEDG SCFDEHGSQL SDDDEDDYDD  60
   61 DKLGGSCGSA DETNKIEDED SESLNQSMPS PGCLSGLSSL QSPSTTMSLA SPLNMNANSA 120
  121 TNVIFPASSN ALLIVGADQP TAQQRPTLVS TSG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [524-751]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSSGSTSSIS TTPNTSSTVS PVTCMTGPCL GSSQERAMML GNRFSHLGMG LSPPVVSTST  60
   61 SKSEPFFKPH PTVCNNPIFA LPSIGNCSLN ISSMPNTSRN PIGANPRDIN NPLSINQLTK 120
  121 RREYKNVELI EASESKTIVA HAATSIIQHV AVNGYHANHS LLNSNLGHLH HQLNNRTENP 180
  181 NRSEQTMLSV SNHSVNSSEC HKESDSQAIV SSNPPNAGSS DNGVISVS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle