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View Structure Prediction Details

Protein: Dr-PA
Organism: Drosophila melanogaster
Length: 515 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Dr-PA.

Description E-value Query
Range
Subject
Range
gi|1098680, gi|2... - gi|2253498|gb|AAB62975.1| muscle segment homeobox [Drosophila melanogaster], sp|Q03372|HMSH_DROME Mu...
121.0 [0..1] [515..1]

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Predicted Domain #1
Region A:
Residues: [1-180]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLKLSPASMT VTGLRQTMTS PTVPPSSNTP AGNLIITSSS SNSGSNSGSN MSSGNMTSSN  60
   61 LTNLSPSHPA GLNALASPTS PSALLLAHQQ HLLQQHQQHQ QQQQQQQQAA ALQLAAVHPP 120
  121 AHHLHKTTSR LSNFSVASLL ADTRPRTPPN QAADGPQNLT SSAATSPISQ ASSTPPPPPA 180
  181 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.154902
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [181-414]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SAAAQVPANT FHPAAVAHHA HLLQAAHAAA AAHAQHQAMA AQLRQQQQQA DARANSPPAS  60
   61 TSSTPSSTPL GSALGSQGNV ASTPAKNERH SPLGSHTDSE LEYDEEMLQD HEADHDEEED 120
  121 SIVDIEDMNA DDSPRSTPDG LDGSGKSLES PHGPPPGSHM QSTILSPAAL ASGHVPIRPT 180
  181 PFSALAAAAV AWTGMGGGVP WPGTRQMPPF GPPGMFPGAG FGGDANEPPR IKCN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [415-515]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LRKHKPNRKP RTPFTTQQLL SLEKKFREKQ YLSIAERAEF SSSLRLTETQ VKIWFQNRRA  60
   61 KAKRLQEAEI EKIKMAALGR GAPGAQWAMA GYFHPSLMHL G

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.0
Match: 1ig7A
Description: Msx-1 homeodomain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.20953772435302 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.41271657675151 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.26183812259792 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
transcription activator activity 1.77700860354597 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.14886080629275 bayes_pls_golite062009
chromatin binding 0.876241359231159 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle