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View Structure Prediction Details

Protein: lmd-PB
Organism: Drosophila melanogaster
Length: 866 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for lmd-PB.

Description E-value Query
Range
Subject
Range
gi|73948425 - gi|73948425|ref|XP_541659.2| PREDICTED: similar to zinc finger protein 91 (HPF7, HTF10) [Canis famil...
888.0 [0..77] [861..320]

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Predicted Domain #1
Region A:
Residues: [1-273]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSSLKTSQS GGMYVKTSSI SGISSISGKE AASCYGGFMS PPLSANITAN NGEREMFRVP  60
   61 GAKVETNESY ACGELQFPDF SHLCFAAETP NSVFSDCHNY AGQDQQQDSD QDDIVCAAAE 120
  121 NTGMPYQQGQ YTQLNREDIF RFEPEDIARL TGESELPGML QHPQTPYTPY TPYTPYTPCS 180
  181 AQNSQYAVQP ANDSINLDID YFNYDEINCQ SKNQSPCSSP HLDAWLNFNL GEISAAASSS 240
  241 AASPKLGNVF EEQVKEEASP AKLPSMNSTF GTP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [274-460]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KCIPMCASNY EDYANLYQQG SGYSTENYHN NMAQVVEKPN REHKAIWTID ELDELMLGEQ  60
   61 QQFLQHHLQQ QHLQEQQEQL HQPHGQEQQT QNCKDDLVNY LSDEFIKAEE FRSLDSDDDE 120
  121 NYNEEEDDLD NDVFAPPAES DPKPDSTCCD PEAEPENEVI PLICRWTGCD EEFPHQQAFV 180
  181 EHIEKCH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.221849
Match: 1meyC
Description: Designed zinc finger protein
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [461-595]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VDVRKGEDFS CFWLDCPRRY KPFNARYKLL IHMRVHSGEK PNKCPFPGCN KAFSRLENLK  60
   61 IHQRSHTGER PYGCQYKGCL KAFSNSSDRA KHQRTHYDTK PYACQLPGCT KRYTDPSSLR 120
  121 KHVKNHALRN ANGQL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 27.69897
Match: 2gliA
Description: Five-finger GLI1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.70988788192472 bayes_pls_golite062009
nucleic acid binding 4.58713908116892 bayes_pls_golite062009
DNA binding 4.56219307357342 bayes_pls_golite062009
transcription factor activity 3.50954949535763 bayes_pls_golite062009
binding 3.10743787485868 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.31369346002275 bayes_pls_golite062009
transcription activator activity 2.19952417915035 bayes_pls_golite062009
transcription repressor activity 1.64349785387632 bayes_pls_golite062009
chromatin binding 1.53640935908107 bayes_pls_golite062009
sequence-specific DNA binding 1.42975942698743 bayes_pls_golite062009
transcription factor binding 1.39608963544799 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.0497955246512 bayes_pls_golite062009
protein binding 1.00484935878505 bayes_pls_golite062009
transcription cofactor activity 0.77874411480713 bayes_pls_golite062009
catalytic activity 0.245893663605433 bayes_pls_golite062009
transcription corepressor activity 0.10558148421807 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [596-685]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RRKSAGGASV PPSGPKKAAK TRRHSESALV QRGVGAGVGV AVPSAPGDQR QHRSNSCSEA  60
   61 LLLQQHQQQQ QQQQQQQKQH QPENERTTDR 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [686-866]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNCGTGVAAN NNSMNFNELS NCIVIIEHNQ SGGPAGPATL ATATATTTAT ATYGNGNMAP  60
   61 APETEVLSVC SGGGSSNSNS NNNRYNANIN QLSELEQLLT TAKPTGTPAA SANGISLANN 120
  121 NGRANGDSKC HLSEFVSFEY VTKYLTDVYE PQCKSPQPPA NFHLQPEFDN SFDMLDFPQF 180
  181 I

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 54.69897
Match: 2i13A
Description: No description for 2i13A was found.

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Created and Maintained by: Michael Riffle