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View Structure Prediction Details

Protein: how-PA, how-PD
Organism: Drosophila melanogaster
Length: 405 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for how-PA, how-PD.

Description E-value Query
Range
Subject
Range
gi|2190986 - gi|2190986|gb|AAB60946.1| KH-domain protein KH93F [Drosophila melanogaster]
368.0 [0..57] [405..59]

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Predicted Domain #1
Region A:
Residues: [1-143]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVCESKAVV QQQLQQHLQQ QAAAAVVAVA QQQQAQAQAQ AQAQAQQQQQ APQVVVPMTP  60
   61 QHLTPQQQQQ STQSIADYLA QLLKDRKQLA AFPNVFTHVE RLLDEEIARV RASLFQINGV 120
  121 KKEPLTLPEP EGSVVTMNEK VYV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [144-270]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PVREHPDFNF VGRILGPRGM TAKQLEQETG CKIMVRGKGS MRDKKKEDAN RGKPNWEHLS  60
   61 DDLHVLITVE DTENRATVKL AQAVAEVQKL LVPQAEGEDE LKKRQLMELA IINGTYRDTT 120
  121 AKSVAVC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 49.39794
Match: 2bl5A
Description: Solution structure of the KH-QUA2 region of the Xenopus STAR-GSG Quaking protein.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleic acid binding 4.28581120742478 bayes_pls_golite062009
RNA binding 4.07234389285213 bayes_pls_golite062009
binding 3.45962790790935 bayes_pls_golite062009
mRNA binding 2.74771386314615 bayes_pls_golite062009
protein binding 2.21586499514642 bayes_pls_golite062009
transcription regulator activity 2.01194399592256 bayes_pls_golite062009
DNA binding 1.78469836520678 bayes_pls_golite062009
transcription factor activity 0.866815968834173 bayes_pls_golite062009
0.649281624091344 bayes_pls_golite062009
structure-specific DNA binding 0.64468203163713 bayes_pls_golite062009
transcription repressor activity 0.594072241231183 bayes_pls_golite062009
single-stranded DNA binding 0.28490151670131 bayes_pls_golite062009
transcription activator activity 0.210494225017032 bayes_pls_golite062009
transcription factor binding 0.139588254197875 bayes_pls_golite062009
catalytic activity 0.113112541746059 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [271-405]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DEEWRRLVAA SDSRLLTSTG LPGLAAQIRA PAAAPLGAPL ILNPRMTVPT TAASILSAQA  60
   61 APTAAFDQTG HGMIFAPYDY ANYAALAGNP LLTEYADHSV GAIKQQRRLA TNREHPYQRA 120
  121 TVGVPAKPAG FIEIQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
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