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View Structure Prediction Details

Protein: trem-PA
Organism: Drosophila melanogaster
Length: 439 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for trem-PA.

Description E-value Query
Range
Subject
Range
gi|73947291 - gi|73947291|ref|XP_541354.2| PREDICTED: similar to Zinc finger protein 606 (Zinc finger protein 328)...
658.0 [0..3] [438..2430]

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Predicted Domain #1
Region A:
Residues: [1-113]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKTESNEKWV VCRVCLNNPS EGEELLHDIF SETASTRLDQ MLHICAGIPV SLDDNFPDKM  60
   61 CSKCVRCLRL CYKFRLTCQR SHQHIMDMLD REASNANAAG EGDLLSIAED LSV

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.08
Match: 1pzwA
Description: Crystal structure of the zinc finger associated domain of the Drosophila transcription factor Grauzone
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.27558039325716 bayes_pls_golite062009
transcription regulator activity 2.04365369058994 bayes_pls_golite062009
DNA binding 2.03081693058447 bayes_pls_golite062009
nucleic acid binding 1.91890460542409 bayes_pls_golite062009
protein binding 1.64123046790677 bayes_pls_golite062009
transcription factor activity 1.28005240080126 bayes_pls_golite062009
sequence-specific DNA binding 0.531420912328414 bayes_pls_golite062009
transcription activator activity 0.448420149095895 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.338250967854476 bayes_pls_golite062009
transcription factor binding 0.25088296722645 bayes_pls_golite062009
catalytic activity 0.133319360419662 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 0.0760964730095472 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [114-204]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ESVLKSWEDY ASQLDGGMKV EGEEDQQHQV ITYVVEDGDT DDTNMFDVHD PTQPVPNEIE  60
   61 EAETYAEYEE YELLTNENSP EIAQEKGSTG T

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [205-439]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DVATEEPPEE EIAEDILDSD EDYDPTHAKP EKCDRSGRKP VAYHKNSPKV ETFKKKVGRK  60
   61 PRNKLSTYIC DVCGNIYPTQ ARLTEHMKFH SGVKPHECEI CGRGFVQNQQ LVRHMNTHTG 120
  121 NRPYKCNYCP AAFADRSTKT KHHRIHTKER PYVCDVCSRT FTYSDNLKFH KMIHTGEKPH 180
  181 VCDLCGKGFV KAYKLRLHRE THNRRITWRN DAEESTKAED VKGETPEFLN ELPKE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 61.09691
Match: 2i13A
Description: No description for 2i13A was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle