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View Structure Prediction Details

Protein: Timp-PB
Organism: Drosophila melanogaster
Length: 210 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Timp-PB.

Description E-value Query
Range		 Subject
Range
TIMP1_BOVIN - Metalloproteinase inhibitor 1 OS=Bos taurus GN=TIMP1 PE=1 SV=1
 257.0 [0..3] [201..1]
gi|4157982 - gi|4157982|emb|CAA08989.1| tissue inhibitor of metalloproteases [Drosophila melanogaster]
 257.0 [0..1] [210..1]
gi|2147195 - pir||I47061 collagenase inhibitor - pig
gi|247730, gi|47... - gi|47523144|ref|NP_999022.1| tissue inhibitor of metalloproteinase 1 [Sus scrofa], gi|247730|gb|AAB2...
 253.0 [0..3] [201..1]
TIMP1_PAPCY - Metalloproteinase inhibitor 1 OS=Papio cynocephalus GN=TIMP1 PE=2 SV=1
gi|1363927 - gi|1363927|pir||JC4303 matrix metalloproteinase-1 tissue inhibitor - baboon
 252.0 [0..3] [201..1]
gi|61365717, gi|... - gi|61365717|gb|AAX42752.1| tissue inhibitor of metalloproteinase 1 [synthetic construct], gi|5469612...
 252.0 [0..3] [201..1]
gi|55727794 - gi|55727794|emb|CAH90650.1| hypothetical protein [Pongo abelii]
gi|123995251, gi... - gi|60824290|gb|AAX36674.1| tissue inhibitor of metalloproteinase 1 [synthetic construct], gi|1239952...
TIMP1_PONAB - Metalloproteinase inhibitor 1 OS=Pongo abelii GN=TIMP1 PE=2 SV=1
TIMP1 - TIMP metallopeptidase inhibitor 1
 252.0 [0..3] [201..1]
TIMP1_SHEEP - Metalloproteinase inhibitor 1 OS=Ovis aries GN=TIMP1 PE=2 SV=1
 252.0 [0..3] [201..1]
TIMP1_MACMU - Metalloproteinase inhibitor 1 OS=Macaca mulatta GN=TIMP1 PE=2 SV=1
 248.0 [0..3] [201..1]

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Predicted Domain #1
Region A:
Residues: [1-210] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDLRKHLGLL TLLLVAVFAF YGRPADACSC MPSHPQTHFA QADYVVQLRV LRKSDTIEPG  60
   61 RTTYKVHIKR TYKATSEARR MLRDGRLSTP QDDAMCGINL DLGKVYIVAG RMPTLNICSY 120
  121 YKEYTRMTIT ERHGFSGGYA KATNCTVTPC FGERCFKGRN YADTCKWSPF GKCETNYSAC 180
  181 MPHKVQTVNG VISRCRWRRT QLYRKCMSNP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 62.221849
Match: 1br9A
Description: HUMAN TISSUE INHIBITOR OF METALLOPROTEINASE-2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cytokine activity 2.84942762917954 bayes_pls_golite062009
chemokine activity 2.03758679635269 bayes_pls_golite062009
chemokine receptor binding 2.03758679635269 bayes_pls_golite062009
G-protein-coupled receptor binding 2.02944363005256 bayes_pls_golite062009
metalloendopeptidase inhibitor activity 1.72655910025353 bayes_pls_golite062009
metalloenzyme regulator activity 1.72655910025353 bayes_pls_golite062009
metalloenzyme inhibitor activity 1.72655910025353 bayes_pls_golite062009
endopeptidase inhibitor activity 1.69053016130359 bayes_pls_golite062009
peptidase inhibitor activity 1.63402812071232 bayes_pls_golite062009
binding 1.57363735103063 bayes_pls_golite062009
enzyme inhibitor activity 1.54714635439345 bayes_pls_golite062009
integrin binding 1.46644476563928 bayes_pls_golite062009
protein binding 0.991421648561387 bayes_pls_golite062009
receptor binding 0.927008627415107 bayes_pls_golite062009
enzyme regulator activity 0.0580682428355711 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle