YRC Public Data Repository - Protein Structure Prediction

Protein:	Cypl-PA
Organism:	Drosophila melanogaster
Length:	176 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Cypl-PA.

Description	E-value	Query Range	Subject Range
gi\|50301248 - gi\|50301248\|gb\|AAT73777.1\| TRIM5/cyclophilin A fusion protein [Aotus trivirgatus]	234.0	[0..15]	[174..308]
gi\|50948445, gi\|... - gi\|50948445\|ref\|XP_483750.1\| putative cyclophilin (70.8 kD) (cyp-15) [Oryza sativa (japonica cultiva...	226.0	[0..1]	[173..252]
CPY71_ARATH - Peptidyl-prolyl cis-trans isomerase CYP71 OS=Arabidopsis thaliana GN=CYP71 PE=1 SV=1	226.0	[0..1]	[173..460]
gi\|114683679, gi... - gi\|114683681\|ref\|XP_001156644.1\| PREDICTED: similar to peptidylprolyl isomerase isoform 1 [Pan trogl...	222.0	[0..20]	[175..3]
PPIA - peptidylprolyl isomerase A (cyclophilin A) PPIA_CERAE - (P62938) Peptidyl-prolyl cis-trans isomerase A (EC 5.2.1.8) (PPIase A) (Rotamase A) (Cyclophilin A) ... PPIA_PAPAN - (P62941) Peptidyl-prolyl cis-trans isomerase A (EC 5.2.1.8) (PPIase A) (Rotamase A) (Cyclophilin A) ... PPIA_MACMU - (P62940) Peptidyl-prolyl cis-trans isomerase A (EC 5.2.1.8) (PPIase A) (Rotamase A) (Cyclophilin A) ...	222.0	[0..20]	[175..2]
gi\|55730219, gi\|... - gi\|75061782\|sp\|Q5R8S7\|PPIA_PONPY Peptidyl-prolyl cis-trans isomerase A (PPIase A) (Rotamase A) (Cycl... gi\|197098846 - gi\|197098846\|ref\|NP_001126060.1\| peptidylprolyl isomerase A [Pongo abelii]	222.0	[0..20]	[175..3]

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Predicted Domain #1

Region A:
Residues: [1-176]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSLSDPNNA GGIPDKAWQP HFVTLETSMG EITVELYWKH APNTCRNFAE LSRRGYYNNV  60
   61 VFHRIIRDFM IQGGDPTGTG RGGASIYGSE FADELHGDLR HTGAGILSMA NSGPDTNGSQ 120
  121 FFITLAPTQW LDGKHTIFGR VYTGMEVVKR IGMVETDKND RPVDPLRIIK AKVEKL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	55.154902
Match:	1xwnA
Description:	solution structure of cyclophilin like 1(PPIL1) and insights into its interaction with SKIP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein deacetylase activity	4.3775483906311	bayes_pls_golite062009
histone deacetylase activity	4.29026678196473	bayes_pls_golite062009
peptidyl-prolyl cis-trans isomerase activity	3.73853378771688	bayes_pls_golite062009
cis-trans isomerase activity	3.66963215732405	bayes_pls_golite062009
deacetylase activity	3.49940864924766	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	3.01511519120932	bayes_pls_golite062009
isomerase activity	1.96529188741504	bayes_pls_golite062009
binding	1.46018233647024	bayes_pls_golite062009
unfolded protein binding	1.38124355054041	bayes_pls_golite062009
RNA binding	1.36609500767021	bayes_pls_golite062009
nucleic acid binding	0.939772862764466	bayes_pls_golite062009
catalytic activity	0.748655649755714	bayes_pls_golite062009
hydrolase activity	0.493806105600863	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	0.408539130322443	bayes_pls_golite062009
ubiquitin-protein ligase activity	0.322244688184474	bayes_pls_golite062009
small conjugating protein ligase activity	0.286133802341887	bayes_pls_golite062009
histone binding	0.268719695649015	bayes_pls_golite062009
mRNA binding	0.210589563207907	bayes_pls_golite062009
protein binding	0.130251391659493	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: