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View Structure Prediction Details

Protein: fd59A-PA
Organism: Drosophila melanogaster
Length: 456 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for fd59A-PA.

Description E-value Query
Range
Subject
Range
gi|19527655 - gi|19527655|gb|AAL89942.1| SD02951p [Drosophila melanogaster]
374.0 [0..1] [456..1]

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Predicted Domain #1
Region A:
Residues: [1-73]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHTSTDPMHT LHDSVSLSPP LIKSSRGGSS IGNGIGCSAS SRTAAADAMS MGCDDSDIEP  60
   61 SSMGGSGAAG GNG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [74-182]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DGSGSSGGPL VKPPYSYIAL ITMAILQSPH KKLTLSGICD FIMSRFPYYK DKFPAWQNSI  60
   61 RHNLSLNDCF IKVPREPGNP GKGNFWTLDP LAEDMFDNGS FLRRRKRYK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.39794
Match: 2hdcA
Description: Genesis
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.55329976718261 bayes_pls_golite062009
DNA binding 5.08959163553491 bayes_pls_golite062009
nucleic acid binding 4.99681957904233 bayes_pls_golite062009
transcription factor activity 4.33152142980289 bayes_pls_golite062009
transcription repressor activity 3.85678231380989 bayes_pls_golite062009
transcription activator activity 3.70589483230587 bayes_pls_golite062009
sequence-specific DNA binding 3.58179858678904 bayes_pls_golite062009
binding 3.52874320222492 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.60738445921725 bayes_pls_golite062009
protein binding 1.80415286835431 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.2723726467408 bayes_pls_golite062009
specific transcriptional repressor activity 0.96257232341735 bayes_pls_golite062009
transcription factor binding 0.85714789329232 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.66743181561551 bayes_pls_golite062009
transcription corepressor activity 0.322180400748724 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.23177057841536 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [183-351]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RAPTMQRFSF PAVFGTLSPF WIRKPVPLVP VHFNVPNFNG SREFDVVHNP ADVFDSALRA  60
   61 DKKFNFFANA EASFYQGSQS GDKFDRLPFM NRGRGADVLD ALPHSSGSGG GVGGGSESSR 120
  121 GSKYKSPYAF DVATVASAAG IPGHRDYAER LSAGGGYMDL NVYNDDADT

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [352-456]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EADAEAEGDD DSCEDKIDVE SGNEQEDSHI SDSVDSACTN RLDAPPEALI FEASAEASDS  60
   61 SPRRRFDSEP LVLRTSKQSS AKDFRIETLI GHHLHRGGSQ EETSD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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