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View Structure Prediction Details

Protein: dve-PA
Organism: Drosophila melanogaster
Length: 1024 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for dve-PA.

Description E-value Query
Range
Subject
Range
gi|3523073, gi|7... - pir||T00117 dve protein - fruit fly (Drosophila melanogaster), gi|3523073|dbj|BAA32660.1| Dve [Dros...
1022.0 [0..1] [1024..1]

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Predicted Domain #1
Region A:
Residues: [1-249]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDFQSAMETF AEAWVAANAG QQSQALALTR AVNAAAVVAS ANAKSPNASS SASASLADLA  60
   61 VKKEHSISPP HSVVSVGVGV AGEDQHRRSS LQGVQEKLTQ LQMQQQHHQQ QQQQQQQQQQ 120
  121 QHQQQQQHHH HQQQAQQAGA GVGSGELAGR RSSEGTPPTA HPPTNSEGQA LSSSTASSSQ 180
  181 NATPKSDRER ERERERDREE RVERGSISCL PPAALGMAVG VQQAQHQEKL LSHPALDSRR 240
  241 EFDVSKVNP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [250-440]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KSLPLHCVVE SVHSLHASLT IDTRQPWKRR PNIETDSYVI IAAATPWSEI VQTALQRLGY  60
   61 SQEVANTARG SLIIKHWKPI PLEQISDNPA VPVSDIVGEL TSVITLRIVI LRPKTSPFGE 120
  121 IKDKLLKLLV LQSHAVLRST GCPLDEVTLS QICRSSHQNT YALPGGEISD ELRRKFDQWW 180
  181 SNQLSPQATA M

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [441-538]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TPKMLPFMTG PSAVPVPVAV PGEMDFPVGT AMAAAAAAAA HAAAAGGAAG GNPLGSMGSR  60
   61 ESLLLANEAA HHAGAGQAPG PGHHGSMLVH PMHASMHH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [539-873]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HHHHGGGGGH GPPYPNQKTR MRTSFDPEME LPKLQKWFAD NPHPSRQQIQ TYVVQLNALE  60
   61 SRRGRKPLDV NNVVYWFKNA RAAQKRAEMR GGSLGSAISA LGHAAMNGYL SQHAPLGQNS 120
  121 SSSAGSQPMS MGNLSMSHDY LKSPLSLKSE DIDTMSQHSD DMDEEQSRPN TPQLPLSLTT 180
  181 HERHRSSPLM DEDEDEAGEQ QQPQEAKSDG MNGSVKDEER QEKSRDELQD NEKENSNGED 240
  241 RHLDADAQME ASSNLNNNHN NSSLHIEQEV GSTPKRSTPK EEDDDLDMDE DEEDNENDAS 300
  301 HLDEFRSPSP DLAGGVVPHK DQLPFPMVPN SMFSQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.045757
Match: 1epwA
Description: Botulinum neurotoxin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.40096962515027 bayes_pls_golite062009
transcription regulator activity 2.15398264148864 bayes_pls_golite062009
nucleic acid binding 1.95513305822187 bayes_pls_golite062009
DNA binding 1.80079581406991 bayes_pls_golite062009
transcription factor activity 1.15427978494805 bayes_pls_golite062009
protein binding 0.757492117682468 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [874-1024]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SFMYMSHYIP AFGQAAAGHP HHHAAAAAAA AGIQPNALMG GGGLNLSSIS NEERRKRNRT  60
   61 FIDPVTEVPK LEQWFAMNTH PSHNLILKYT EDLNTMPYRQ KFPRLESKNV QFWFKNRRAK 120
  121 CKRLKMSLYD SNQCAQLGGL GSFVPKYEER D

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.27
Match: 1o4xA
Description: TERNARY COMPLEX OF THE DNA BINDING DOMAINS OF THE OCT1 AND SOX2 TRANSCRIPTION FACTORS WITH A 19MER OLIGONUCLEOTIDE FROM THE HOXB1 REGULATORY ELEMENT
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.86538715425734 bayes_pls_golite062009
DNA binding 4.40186699787632 bayes_pls_golite062009
nucleic acid binding 4.28652307290136 bayes_pls_golite062009
transcription factor activity 3.78935192723648 bayes_pls_golite062009
binding 2.92574888336072 bayes_pls_golite062009
sequence-specific DNA binding 2.15328641013602 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.00875399167309 bayes_pls_golite062009
transcription repressor activity 1.69615348178304 bayes_pls_golite062009
transcription activator activity 1.5973137667873 bayes_pls_golite062009
transcription factor binding 1.24678737091956 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.865913662624162 bayes_pls_golite062009
chromatin binding 0.82130998265632 bayes_pls_golite062009
protein binding 0.795494287543952 bayes_pls_golite062009
transcription cofactor activity 0.691780246385357 bayes_pls_golite062009
transcription corepressor activity 0.0723215858239072 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle